Exposure to fibrillar proteins leads to widespread infiltration but only mild tau pathology in cortical organoids.
Overview
- Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, 75185 Uppsala, Sweden
- Science for Life Laboratory, Uppsala University, Uppsala, Sweden
Abstract
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common neurodegenerative disorders, both characterized by accumulation of aggregated proteins. In AD, the pathological deposits consist predominantly of amyloid-beta (Aβ) and tau, while alpha-synuclein (αSYN) forms inclusions in PD. However, cross-seeding often generates mixed pathologies. Emerging evidence suggests a role of astrocytes in disease spreading, but the underlying mechanisms remain unclear, partly due to limitations of mouse models in replicating early human disease. To address this, we developed a human cerebral organoid platform to study early sporadic AD/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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The paper's code and data availability statement is in the Data section.
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Data and code availability
Western blot images generated are included in the article and supplementary figures. Additional microscopy data reported here will be shared by the lead contact upon request.
This study does not report original code.
Any additional information required to reanalyze the data reported in this study is available from the lead contact upon request.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 29 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 5 authors, 4 keywords, 11 funders, 43 references, 10 RRIDs.
Cite
This paper
Dakhel, A., Mothes, T., Eltom, K., Michno, W. P., & Erlandsson, A. (2026). Exposure to fibrillar proteins leads to widespread infiltration but only mild tau pathology in cortical organoids. iScience, 29(5), 115819. https://
BibTeX
@article{dakhel2026expos
author = {Dakhel, Abdulkhalek and Mothes, Tobias and Eltom, Khalid and Michno, Wojciech P and Erlandsson, Anna},
title = {{Exposure to fibrillar proteins leads to widespread infiltration but only mild tau pathology in cortical organoids}},
journal = {iScience},
year = {2026},
month = apr,
volume = {29},
number = {5},
pages = {115819},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/
url = {https://
pmid = {42111182},
pmcid = {PMC13157081}
}
RIS
TY - JOUR
AU - Dakhel, Abdulkhalek
AU - Mothes, Tobias
AU - Eltom, Khalid
AU - Michno, Wojciech P
AU - Erlandsson, Anna
TI - Exposure to fibrillar proteins leads to widespread infiltration but only mild tau pathology in cortical organoids
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/
VL - 29
IS - 5
SP - 115819
SN - 2589-0042
PB - Elsevier
DO - 10.1016/
UR - https://
LA - en
ER -
CSL-JSON
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"family": "Dakhel",
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"given": "Khalid"
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"given": "Wojciech P"
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"family": "Erlandsson",
"given": "Anna"
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"URL": "https://
"language": "en",
"issued": {
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}
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