Virus-host interactome reveals host cellular pathways perturbed by tick-borne encephalitis virus infection.
Overview
- Department of Infectious Diseases and Center of Infectious Diseases and Pathogen Biology, Key Laboratory of Organ Regeneration and Transplantation of the Ministry of Education, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, The First Hospital of Jilin University, Changchun 130012, China
- Biomaterials and Translational Medicine, Puheng Technology Co., Ltd, Suzhou 215163, China
- College of Basic Medical Science, Jilin University, Changchun 130061, China
- Clinical Medical College, Changchun University of Chinese Medicine, Changchun 130117, China
- Chinese Medicine Guangdong Laboratory, Guangdong Hengqin 519000, China
Abstract
Tick-borne encephalitis virus (TBEV) poses an increasingly significant threat to public health. Building on our previous TBEV-host interactome study, we further refine the virus-host interaction network and show that multiple viral proteins, including prM, NS1, NS2B3, NS4A, and NS5, are associated with modulation of diverse host cellular pathways, including innate immune responses, autophagy, ribosomal biogenesis, homologous recombination, and cell cycle regulation. Notably, TBEV infection is associated with a modest but reproducible accumulation of host cells in the G0/
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
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The paper's code and data availability statement is in the Data section.
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Data and code availability
• All data are available in the main text or the supplementary materials. The mass spectrometry data are available in ProteomeX change under the identifier PXD048439. • This study did not generate new code. • Any additional information required to reanalyze the data reported in this article is available from the lead contact upon request.
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
Versions
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Version 1, 29 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 17 authors, 3 keywords, 6 funders, 59 references.
Cite
This paper
Sui, L., Zhao, Y.-H., Wang, H., Chi, H., Xie, H., Tian, T., Wang, W., Zhu, M., Zhai, N., Song, Z., Xu, Y., Zhang, K., Che, L., Wang, G., Liu, N., Zhao, Y., & Liu, Q. (2026). Virus-host interactome reveals host cellular pathways perturbed by tick-borne encephalitis virus infection. iScience, 29(6), 115821. https://
BibTeX
@article{sui2026virus,
author = {Sui, Liyan and Zhao, Ying-Hua and Wang, Heming and Chi, Hongmiao and Xie, Hanxi and Tian, Tian and Wang, Wenfang and Zhu, Mucuo and Zhai, Naicui and Song, Zhixia and Xu, Yueshan and Zhang, Kaiyu and Che, Lihe and Wang, Guoqing and Liu, Nan and Zhao, Yicheng and Liu, Quan},
title = {{Virus-host interactome reveals host cellular pathways perturbed by tick-borne encephalitis virus infection}},
journal = {iScience},
year = {2026},
month = apr,
volume = {29},
number = {6},
pages = {115821},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/
url = {https://
pmid = {42109850},
pmcid = {PMC13156689}
}
RIS
TY - JOUR
AU - Sui, Liyan
AU - Zhao, Ying-Hua
AU - Wang, Heming
AU - Chi, Hongmiao
AU - Xie, Hanxi
AU - Tian, Tian
AU - Wang, Wenfang
AU - Zhu, Mucuo
AU - Zhai, Naicui
AU - Song, Zhixia
AU - Xu, Yueshan
AU - Zhang, Kaiyu
AU - Che, Lihe
AU - Wang, Guoqing
AU - Liu, Nan
AU - Zhao, Yicheng
AU - Liu, Quan
TI - Virus-host interactome reveals host cellular pathways perturbed by tick-borne encephalitis virus infection
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/
VL - 29
IS - 6
SP - 115821
SN - 2589-0042
PB - Elsevier
DO - 10.1016/
UR - https://
LA - en
ER -
CSL-JSON
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