Andrographolide attenuates microglial senescence in Alzheimer's disease mice by suppressing the STAT3 signaling.
Overview
- Guangdong Provincial Key Laboratory of Medical Immunology and Molecular Diagnostics, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan 523808, China
- Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China
- Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
Abstract
Andrographolide (AP), a diterpenoid extracted from Andrographis paniculata, has emerged as a promising treatment for Alzheimer’s disease (AD) in preclinical studies, but the underlying mechanisms remain incompletely defined. Here, we demonstrated that AP treatment improved cognition performance and reduced amyloid-β (Aβ) plaque accumulation in 5×FAD transgenic mice of both sexes, by mitigating microglial senescence. Proteomic analysis revealed that AP markedly decreased cholesterol content in the cerebral cortex. Using an in vitro low-density lipoprotein-induced senescence model, we found that AP significantly alleviated senescence in BV2 microglia while enhancing their phagocytic capacity. Mechanistically, AP mitigated microglial senescence by inhibiting STAT3 signaling. Overall, these findings identify a previously unrecognized immunometabolic mechanism for AP in the treatment of AD.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data and code availability
All datasets used in this study are available from the corresponding author upon reasonable request. The mass data used in this study have been deposited in the ProteomeXchange Consortium with the iProX partner repository. The dataset can be authorized using a PXD number: PXD070443 (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
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Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 15 authors, 2 keywords, 2 funders, 67 references, 24 RRIDs.
Cite
This paper
Song, H., Yang, M., Wu, S., Dai, Q., Qin, W., Xie, W., Chen, Y., Jiang, X., Zhang, X., Deng, X., Ouyang, C., Zhang, Y., Liu, X., Zhu, Y., & Huang, G. (2026). Andrographolide attenuates microglial senescence in Alzheimer's disease mice by suppressing the STAT3 signaling. iScience, 29(6), 116033. https://
BibTeX
@article{song2026androgr
author = {Song, Haochang and Yang, Meng and Wu, Shengquan and Dai, Qihui and Qin, Weihong and Xie, Weiheng and Chen, Yuzhi and Jiang, Xiaoyun and Zhang, Xiaojun and Deng, Xiuqin and Ouyang, Chuang and Zhang, Yunman and Liu, Xinguang and Zhu, Yingjie and Huang, Gonghua},
title = {{Andrographolide attenuates microglial senescence in Alzheimer's disease mice by suppressing the STAT3 signaling}},
journal = {iScience},
year = {2026},
month = may,
volume = {29},
number = {6},
pages = {116033},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/
url = {https://
pmid = {42211120},
pmcid = {PMC13214295}
}
RIS
TY - JOUR
AU - Song, Haochang
AU - Yang, Meng
AU - Wu, Shengquan
AU - Dai, Qihui
AU - Qin, Weihong
AU - Xie, Weiheng
AU - Chen, Yuzhi
AU - Jiang, Xiaoyun
AU - Zhang, Xiaojun
AU - Deng, Xiuqin
AU - Ouyang, Chuang
AU - Zhang, Yunman
AU - Liu, Xinguang
AU - Zhu, Yingjie
AU - Huang, Gonghua
TI - Andrographolide attenuates microglial senescence in Alzheimer's disease mice by suppressing the STAT3 signaling
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/
VL - 29
IS - 6
SP - 116033
SN - 2589-0042
PB - Elsevier
DO - 10.1016/
UR - https://
LA - en
ER -
CSL-JSON
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