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Disruption of the brain-spleen axis impairs monocyte-microglia communication and accelerates disease progression in a mouse model of amyloidosis.

Overview

Authors: Tommaso Croese1, Miguel A Abellanas1,2, Hodaya Polonsky3, Michal Arad1, Javier M Peralta Ramos1, Yuliya Androsova1, Serena Riccitelli1, Sedi Medina1, Francesca Palmas4, Romano Strobel5, Giulia Castellani1, Denise Kviatcovsky1,6, Sarah Phoebeluc-Colaiuta1, Miriam Adam3, Sama Murad1, Hannah Partney1, Daniel Kitsberg3, Alexander Dieter7, Tomer-Meir Salame8, Alexander Brandis8
and 9 other authorsTevie Mehlman8, Oded Singer8, Michal Rivlin-Etzion1, Simon Wiegert7, Yosef Shaul5, Oren Kobiler9, Ofer Yizhar1, Naomi Habib3, Michal Schwartz1
ORCID iDs: Tommaso Croese, Miguel A Abellanas, Javier M Peralta Ramos, Romano Strobel, Denise Kviatcovsky, Alexander Dieter, Oded Singer, Michal Rivlin-Etzion, Simon Wiegert, Yosef Shaul, Oren Kobiler, Ofer Yizhar, Naomi Habib, Michal Schwartz
  1. Department of Brain Sciences, Weizmann Institute of Science, Rehovot, Israel
  2. Department of Pharmaceutical Sciences, University of Navarra, Pamplona, Spain
  3. Edmond & Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel
  4. Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy
  5. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel
  6. Immunology, Weizmann Institute of Science, Rehovot, Israel
  7. Department of Neurophysiology, MCTN, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
  8. Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel
  9. Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
Institutions: Weizmann Institute of Science (Israel); Universidad de Navarra (Spain); Hebrew University of Jerusalem (Israel); University of Cagliari (Italy); Heidelberg University (Germany); Medizinische Fakultät Mannheim; Tel Aviv University (Israel)
Journal: Nature communications, volume 17, issue 1, article 7732
Dates: received 24 April 2025; accepted 1 June 2026; published online 19 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-74253-z · PMID 42321169 · PMCID PMC13434638 · OpenAlex W7165139692
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning
Keywords: Neuroimmunology, Neurodegeneration
MeSH: Amyloidosis*, Brain*, Microglia*, Monocytes*, Spleen*, Alzheimer Disease, Animals, Cell Communication, Cognitive Dysfunction, Disease Models, Animal, Disease Progression, Female, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Retinal Ganglion Cells (* major topic)
Topic: Amyloidosis: Diagnosis, Treatment, Outcomes (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: European Research Council (741744, 853409)
Citations: not cited yet (Europe PMC); 94 references in the paper
Research resources: RRID:Addgene_81070

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Code and data availability statement

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Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 29 authors, 2 keywords, 18 MeSH terms, 1 funder, 93 references, 1 RRID.

Cite

This paper

Croese, T., Abellanas, M. A., Polonsky, H., Arad, M., Peralta Ramos, J. M., Androsova, Y., Riccitelli, S., Medina, S., Palmas, F., Strobel, R., Castellani, G., Kviatcovsky, D., Phoebeluc-Colaiuta, S., Adam, M., Murad, S., Partney, H., Kitsberg, D., Dieter, A., Salame, T.-M., . . . Schwartz, M. (2026). Disruption of the brain-spleen axis impairs monocyte-microglia communication and accelerates disease progression in a mouse model of amyloidosis. Nature communications, 17(1), 7732. https://doi.org/10.1038/s41467-026-74253-z

BibTeX

@article{croese2026disruption,
author = {Croese, Tommaso and Abellanas, Miguel A and Polonsky, Hodaya and Arad, Michal and Peralta Ramos, Javier M and Androsova, Yuliya and Riccitelli, Serena and Medina, Sedi and Palmas, Francesca and Strobel, Romano and Castellani, Giulia and Kviatcovsky, Denise and Phoebeluc-Colaiuta, Sarah and Adam, Miriam and Murad, Sama and Partney, Hannah and Kitsberg, Daniel and Dieter, Alexander and Salame, Tomer-Meir and Brandis, Alexander and Mehlman, Tevie and Singer, Oded and Rivlin-Etzion, Michal and Wiegert, Simon and Shaul, Yosef and Kobiler, Oren and Yizhar, Ofer and Habib, Naomi and Schwartz, Michal},
title = {{Disruption of the brain-spleen axis impairs monocyte-microglia communication and accelerates disease progression in a mouse model of amyloidosis}},
journal = {Nature communications},
year = {2026},
month = jun,
volume = {17},
number = {1},
pages = {7732},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-74253-z},
url = {https://doi.org/10.1038/s41467-026-74253-z},
pmid = {42321169},
pmcid = {PMC13434638}
}

RIS

TY - JOUR
AU - Croese, Tommaso
AU - Abellanas, Miguel A
AU - Polonsky, Hodaya
AU - Arad, Michal
AU - Peralta Ramos, Javier M
AU - Androsova, Yuliya
AU - Riccitelli, Serena
AU - Medina, Sedi
AU - Palmas, Francesca
AU - Strobel, Romano
AU - Castellani, Giulia
AU - Kviatcovsky, Denise
AU - Phoebeluc-Colaiuta, Sarah
AU - Adam, Miriam
AU - Murad, Sama
AU - Partney, Hannah
AU - Kitsberg, Daniel
AU - Dieter, Alexander
AU - Salame, Tomer-Meir
AU - Brandis, Alexander
AU - Mehlman, Tevie
AU - Singer, Oded
AU - Rivlin-Etzion, Michal
AU - Wiegert, Simon
AU - Shaul, Yosef
AU - Kobiler, Oren
AU - Yizhar, Ofer
AU - Habib, Naomi
AU - Schwartz, Michal
TI - Disruption of the brain-spleen axis impairs monocyte-microglia communication and accelerates disease progression in a mouse model of amyloidosis
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/06/19
VL - 17
IS - 1
SP - 7732
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-74253-z
UR - https://doi.org/10.1038/s41467-026-74253-z
LA - en
ER -

CSL-JSON

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