OSCR

A role for nucleolin in functional improvement in stroke.

Overview

Authors: Samuel P Bridges1, Mary Hovanesyan1, Srbui Azarapetian1, Ofri Abraham2, Ida Rishal2, Mike Fainzilber2, S Thomas Carmichael1
ORCID iDs: S Thomas Carmichael
  1. Department of Neurology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
  2. Departments of Biomolecular Sciences and Molecular Neuroscience, Weizmann Institute of Science, Rehovot 7610001, Israel
Institutions: University of California, Los Angeles (United States); Weizmann Institute of Science (Israel)
Journal: iScience, volume 29, issue 6, article 116134
Dates: received 8 October 2025; accepted 12 May 2026; published online 1 June 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1016/j.isci.2026.116134 · PMID 42291226 · PMCID PMC13253107 · OpenAlex W7163079056
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: stroke (population), cellular / molecular (subfield)
Methods: Statistics
Keywords: molecular biology, neuroscience, cell biology
Topic: Neuroinflammation and Neurodegeneration Mechanisms (Neurology, Neuroscience), according to OpenAlex
Funding: Dr. Miriam and Sheldon G. Adelson Medical Research Foundation; United States - Israel Binational Science Foundation (2023327); Weizmann Institute of Science
Citations: not cited yet (Europe PMC); 41 references in the paper
Research resources: Rabbit anti-nucleolin RRID:AB_11144140, Goat anti-Iba1 RRID:AB_2224402, Rat anti-GFAP RRID:AB_2532994, Guinea pig anti-NeuN RRID:AB_2619988, Rabbit anti-flag RRID:AB_347227, pAAV-CAG-flex-Ruby2sm-Flag-WPRE RRID:Addgene_98928

Abstract

Stroke remains a global health concern and a leading cause of adult-onset disability due to limited intrinsic repair capability. Here, we identify nucleolin as a targetable regulator of the repair programs activated following ischemic injury. Through neuron-specific subcellular targeting of axonal nucleolin in the post-stroke recovery period, we see enhanced axonal sprouting and accelerated functional recovery following motor cortex stroke. These findings demonstrate that interference in localized nucleolin functions following cortical stroke is a viable strategy to enhance functional recovery.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

The paper's code and data availability statement is in the Data section.

Tracing map

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Data

No dataset and no data link were found in the paper.

Data and code availability

Data: Data reported in this paper will be shared by the lead contact upon request.

Code: Original code reported in this paper will be shared by the lead contact upon request.

Additional resources: Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 3 keywords, 3 funders, 41 references, 6 RRIDs.

Cite

This paper

Bridges, S. P., Hovanesyan, M., Azarapetian, S., Abraham, O., Rishal, I., Fainzilber, M., & Carmichael, S. T. (2026). A role for nucleolin in functional improvement in stroke. iScience, 29(6), 116134. https://doi.org/10.1016/j.isci.2026.116134

BibTeX

@article{bridges2026role,
author = {Bridges, Samuel P and Hovanesyan, Mary and Azarapetian, Srbui and Abraham, Ofri and Rishal, Ida and Fainzilber, Mike and Carmichael, S Thomas},
title = {{A role for nucleolin in functional improvement in stroke}},
journal = {iScience},
year = {2026},
month = jun,
volume = {29},
number = {6},
pages = {116134},
publisher = {Elsevier},
issn = {2589-0042},
doi = {10.1016/j.isci.2026.116134},
url = {https://doi.org/10.1016/j.isci.2026.116134},
pmid = {42291226},
pmcid = {PMC13253107}
}

RIS

TY - JOUR
AU - Bridges, Samuel P
AU - Hovanesyan, Mary
AU - Azarapetian, Srbui
AU - Abraham, Ofri
AU - Rishal, Ida
AU - Fainzilber, Mike
AU - Carmichael, S Thomas
TI - A role for nucleolin in functional improvement in stroke
T2 - iScience
J2 - iScience
PY - 2026
DA - 2026/06/01
VL - 29
IS - 6
SP - 116134
SN - 2589-0042
PB - Elsevier
DO - 10.1016/j.isci.2026.116134
UR - https://doi.org/10.1016/j.isci.2026.116134
LA - en
ER -

CSL-JSON

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