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Acute requirement for the hippocampus in putatively conscious vision revealed by a mouse model of blindsight.

A correction to this paper has been published: the notice, 42330918, from Europe PMC.

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  1. MiceVR for Michael Stryker, UCSF

README.md at commit f528262, no license · at the source

Overview

Authors: Nikhil Bhatla1,2,3,4,5,6, Kathryn Cheong2, Sho Takahashi2, Corliss Lay2, Matthew Fiedeldey2, Kathleen Liang2, Mo Mao2, Yun-Fan Wu2, Sandy Lu2, Karis Yun2, Viveca Ganti2, Raymond Tsao2, Xiaozhou Zhang2, Kenzy A. Mohamed2, Yul Chang2, Yucong Geng2, Casey Dai2, Ashley K. Liu2, Yee May Lwin2, Heidi Kim2
and 10 other authorsVamsi Subraveti2, Narumi Mitchell2, Na Youn Jo2, Umais Khan5, Roger Anguera-Singla7, Zephyr Weinreich8, Hanna E. Willis9, Holly Bridge9, Michael P. Stryker5, Hillel Adesnik2,3
ORCID iDs: Nikhil Bhatla, Matthew Fiedeldey, Kathleen Liang, Heidi Kim, Umais Khan, Hanna E. Willis, Holly Bridge, Michael P. Stryker
  1. Institute for All Minds, Berkeley, CA 94704, USA
  2. Department of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, CA 94720, USA
  3. Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
  4. Miller Institute for Basic Research, University of California, Berkeley, Berkeley, CA 94720, USA
  5. Department of Physiology, University of California, San Francisco, San Francisco, CA 94158, USA
  6. Lead contact
  7. Department of Neurology, Neuroscape and Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA 94158, USA
  8. Swarthmore College, Swarthmore, PA 19081, USA
  9. Centre for Integrative Neuroimaging, Centre for Functional Magnetic Resonance Imaging of the Brain, Nuffield Department of Clinical Neuroscience, University of Oxford, Oxford OX3 9DU, UK
Institutions: University of California, San Francisco (United States); University of California, Berkeley (United States); Swarthmore College (United States); University of Oxford (United Kingdom); Wellcome Centre for Integrative Neuroimaging (United Kingdom)
Journal: Current biology : CB, volume 36, issue 8, pages 2043-2062.e7
Dates: published online 9 April 2026; in print 20 April 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1016/j.cub.2026.03.031 · PMID 41962536 · PMCID PMC13393572 · OpenAlex W7152449394
Open access: hybrid, a free copy (OpenAlex)
Status: code verified
Categories: human (organism), mouse (organism), other condition (population), cognitive (subfield)
Methods: Statistics, Connectivity, fMRI & imaging, Physiology & signal measures
Keywords: Hippocampus, Vision, Consciousness, perception, Unconsciousness, Blindsight, Lgn, V1, Subjective Experience, Conscious Vision
MeSH: Blindness*, Consciousness*, Hippocampus*, Primary Visual Cortex*, Visual Cortex*, Visual Perception*, Animals, Disease Models, Animal, Male, Mice, Mice, Inbred C57BL (* major topic)
Topic: Memory and Neural Mechanisms (Cognitive Neuroscience, Neuroscience), according to OpenAlex
Funding: Medical Research Council (2017 LIGHTUP 772953, MR/N013468/1); Templeton World Charity Foundation Inc (2022-30257); Medical Research Foundation; National Institutes of Health; British Medical Association; The Chan Zuckerberg Initiative; NEI NIH HHS (R01 EY002874, R01 EY023756); University of California Berkeley Miller Institute for Basic Research in Science; National Eye Institute (R01EY002874, R01EY023756); The Queen's College Oxford
Citations: not cited yet (Europe PMC); 149 references in the paper
Research resources: RRID:AB_143165, RRID:AB_162543, RRID:AB_221605, RRID:AB_2532109, Mouse: C57BL/6 RRID:IMSR_CRL:027
Notices: A correction to this paper has been published (42330918, from Europe PMC)

Abstract

The phenomenon of blindsight provides a unique opportunity to uncover brain areas important for conscious vision. Patients with blindsight lose the conscious experience of seeing while still being able to detect and locate visual stimuli. Blindsight occurs after damage to the primary visual cortex (V1). Rodents are likewise able to detect and locate visual stimuli after damage to V1, though whether they lose conscious vision as humans do is unclear. Here, we report the first mouse model of blindsight that provides evidence that removal of V1 causes mice to lose their putatively conscious vision. This loss occurs only if dLGN, a brain area in the thalamus that connects to V1, is damaged in addition to V1. We use this model to discover that suppressing the hippocampus acutely causes blindsight-like behavior. This suggests that the hippocampus functions in the intact brain to support conscious, but not unconscious, vision. Furthermore, while single, selective ablations of V1 or the hippocampus have only a minor effect on vision, simultaneous ablation causes blindsight-like behavior. These results suggest that V1 and the hippocampus can compensate for the permanent loss of the other for conscious vision, revealing a novel form of plasticity that supports conscious vision. Although never causally implicated in conscious visual perception, the hippocampus emerges as a candidate brain area critical for conscious experience. More broadly, this mouse model of blindsight will enable the interrogation and identification of the neural circuits that underlie conscious and unconscious vision.

Reproduced under the paper's license (CC BY), from the paper cited above.

Repositories

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nbhatla/micevr

License: none: the authors keep all their rights
State: the link answers, verified on 29 September 2026
Evidence: files inventoried
Commit: f5282626829b5d848ecfb83fcf5cb617dfc18863, 8 March 2017
Size: 1,043 files, 0 scripts
Software Heritage: not archived
Found in: “Data and code availability”
Holds: README
Not found: license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 29 September 2026: the link answers
  • 29 September 2026: the link answers
1 file
At the source: github.com/nbhatla/MiceVR/tree/KeepFromEscape

allensdk.readthedocs.io

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Software Heritage: not checked
Found in: the text, “Allen Brain Observatory Neuropixels analysis”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 29 September 2026: the link answers (HTTP 200)
  • 29 September 2026: the link answers (HTTP 200)
At the source: allensdk.readthedocs.io/en/latest/visual_coding_neuropixels.html

The paper's code and data availability statement is in the Data section.

Tracing map

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Data

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Data and code availability

All data are available from http://iam.science/data.

All code is available from http://github.com/nbhatla/MiceVR/tree/KeepFromEscape.

Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.

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Versions

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Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 30 authors, 10 keywords, 11 MeSH terms, 10 funders, 142 references, 5 RRIDs, 1 integrity notice.

Cite

This paper

Bhatla, N., Cheong, K., Takahashi, S., Lay, C., Fiedeldey, M., Liang, K., Mao, M., Wu, Y.-F., Lu, S., Yun, K., Ganti, V., Tsao, R., Zhang, X., Mohamed, K. A., Chang, Y., Geng, Y., Dai, C., Liu, A. K., Lwin, Y. M., . . . Adesnik, H. (2026). Acute requirement for the hippocampus in putatively conscious vision revealed by a mouse model of blindsight. Current biology : CB, 36(8), 2043-2062.e7. https://doi.org/10.1016/j.cub.2026.03.031

BibTeX

@article{bhatla2026acute,
author = {Bhatla, Nikhil and Cheong, Kathryn and Takahashi, Sho and Lay, Corliss and Fiedeldey, Matthew and Liang, Kathleen and Mao, Mo and Wu, Yun-Fan and Lu, Sandy and Yun, Karis and Ganti, Viveca and Tsao, Raymond and Zhang, Xiaozhou and Mohamed, Kenzy A. and Chang, Yul and Geng, Yucong and Dai, Casey and Liu, Ashley K. and Lwin, Yee May and Kim, Heidi and Subraveti, Vamsi and Mitchell, Narumi and Jo, Na Youn and Khan, Umais and Anguera-Singla, Roger and Weinreich, Zephyr and Willis, Hanna E. and Bridge, Holly and Stryker, Michael P. and Adesnik, Hillel},
title = {{Acute requirement for the hippocampus in putatively conscious vision revealed by a mouse model of blindsight}},
journal = {Current biology : CB},
year = {2026},
month = apr,
volume = {36},
number = {8},
pages = {2043--2062.e7},
publisher = {Elsevier BV},
issn = {0960-9822},
doi = {10.1016/j.cub.2026.03.031},
url = {https://doi.org/10.1016/j.cub.2026.03.031},
pmid = {41962536},
pmcid = {PMC13393572}
}

RIS

TY - JOUR
AU - Bhatla, Nikhil
AU - Cheong, Kathryn
AU - Takahashi, Sho
AU - Lay, Corliss
AU - Fiedeldey, Matthew
AU - Liang, Kathleen
AU - Mao, Mo
AU - Wu, Yun-Fan
AU - Lu, Sandy
AU - Yun, Karis
AU - Ganti, Viveca
AU - Tsao, Raymond
AU - Zhang, Xiaozhou
AU - Mohamed, Kenzy A.
AU - Chang, Yul
AU - Geng, Yucong
AU - Dai, Casey
AU - Liu, Ashley K.
AU - Lwin, Yee May
AU - Kim, Heidi
AU - Subraveti, Vamsi
AU - Mitchell, Narumi
AU - Jo, Na Youn
AU - Khan, Umais
AU - Anguera-Singla, Roger
AU - Weinreich, Zephyr
AU - Willis, Hanna E.
AU - Bridge, Holly
AU - Stryker, Michael P.
AU - Adesnik, Hillel
TI - Acute requirement for the hippocampus in putatively conscious vision revealed by a mouse model of blindsight
T2 - Current biology : CB
J2 - Curr Biol
PY - 2026
DA - 2026/04/09
VL - 36
IS - 8
SP - 2043
EP - 2062.e7
SN - 0960-9822
PB - Elsevier BV
DO - 10.1016/j.cub.2026.03.031
UR - https://doi.org/10.1016/j.cub.2026.03.031
LA - en
ER -

CSL-JSON

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