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The Src family kinase YES regulates DNAJB6b chaperone activity to modulate tau aggregation in Alzheimer's disease.

Overview

Authors: Meng-Chieh Lin1, Huan-Yun Chen1,2, Te-Sheng Lin3, Sue-Jane Lin1, Pei-Jie Lin1, Chia-Yu Liao1, Nei-Li Chan3,4, Chin-Hsien Lin2, Shu-Chun Teng1,4
ORCID iDs: Te-Sheng Lin, Shu-Chun Teng
  1. Department of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
  2. Department of Neurology, National Taiwan University Hospital, Taipei, Taiwan
  3. Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, Taipei, Taiwan
  4. Center for Precision Medicine, National Taiwan University, Taipei, Taiwan
Institutions: National Taiwan University (Taiwan); National Taiwan University Hospital (Taiwan)
Journal: The Journal of biological chemistry, volume 302, issue 9, article 113363
Dates: received 2 December 2025; published online 24 July 2026; in print September 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1016/j.jbc.2026.113363 · PMID 42497989 · PMCID PMC13503143 · OpenAlex W7170400726
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Statistics, Preprocessing, Evoked potentials
Keywords: Alzheimer’s disease, co-chaperone, DNAJB6b, J-domain proteins, Src family kinases, tau, YES
MeSH: Alzheimer Disease*, HSP40 Heat-Shock Proteins*, Molecular Chaperones*, Nerve Tissue Proteins*, Proto-Oncogene Proteins c-yes*, tau Proteins*, Humans, Phosphorylation, Protein Aggregates (* major topic)
Topic: Heat shock proteins research (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Science and Technology Council (112-2311-B-002 -015 -MY3); National Taiwan University Hospital (NHRI-EX113-11136NI)
Citations: not cited yet (Europe PMC); 63 references in the paper

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a gradual deterioration of memory. While its prevalence increases with age, the underlying mechanisms remain incompletely understood. Here, we examine the biological consequences of phosphorylation-mediated chaperone activity in AD-associated tau aggregates. Increased phosphorylation of DNAJB6b at Y53 is observed in the brain lysates of AD patients. Our research found that an activated Src family kinase, YES, phosphorylates Y53 in the J-domain of DNAJB6b and enhances the binding between DNAJB6b and Hsp70. The strengthened association between DNAJB6b and Hsp70 may lead to the accumulation of tau aggregates. These findings suggest that up-regulation of YES kinase modifies DNAJB6b and that the resulting alteration in DNAJB6b-dependent tau disaggregation may contribute to an increased risk of AD.

Reproduced under the paper's license (CC BY), from the paper cited above.

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Data

Datasets cited

Data availability

All data are available upon reasonable request and directed to the corresponding authors. All materials generated in this study are available from the corresponding authors with a completed Material Transfer Agreement.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Authors: added Te-Sheng Lin (0000-0002-4388-4657); removed Te-Sheng Lin

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 7 keywords, 9 MeSH terms, 2 funders, 62 references.

Cite

This paper

Lin, M.-C., Chen, H.-Y., Lin, T.-S., Lin, S.-J., Lin, P.-J., Liao, C.-Y., Chan, N.-L., Lin, C.-H., & Teng, S.-C. (2026). The Src family kinase YES regulates DNAJB6b chaperone activity to modulate tau aggregation in Alzheimer's disease. The Journal of biological chemistry, 302(9), 113363. https://doi.org/10.1016/j.jbc.2026.113363

BibTeX

@article{lin2026src,
author = {Lin, Meng-Chieh and Chen, Huan-Yun and Lin, Te-Sheng and Lin, Sue-Jane and Lin, Pei-Jie and Liao, Chia-Yu and Chan, Nei-Li and Lin, Chin-Hsien and Teng, Shu-Chun},
title = {{The Src family kinase YES regulates DNAJB6b chaperone activity to modulate tau aggregation in Alzheimer's disease}},
journal = {The Journal of biological chemistry},
year = {2026},
month = jul,
volume = {302},
number = {9},
pages = {113363},
publisher = {American Society for Biochemistry and Molecular Biology},
issn = {0021-9258},
doi = {10.1016/j.jbc.2026.113363},
url = {https://doi.org/10.1016/j.jbc.2026.113363},
pmid = {42497989},
pmcid = {PMC13503143}
}

RIS

TY - JOUR
AU - Lin, Meng-Chieh
AU - Chen, Huan-Yun
AU - Lin, Te-Sheng
AU - Lin, Sue-Jane
AU - Lin, Pei-Jie
AU - Liao, Chia-Yu
AU - Chan, Nei-Li
AU - Lin, Chin-Hsien
AU - Teng, Shu-Chun
TI - The Src family kinase YES regulates DNAJB6b chaperone activity to modulate tau aggregation in Alzheimer's disease
T2 - The Journal of biological chemistry
J2 - J Biol Chem
PY - 2026
DA - 2026/07/24
VL - 302
IS - 9
SP - 113363
SN - 0021-9258
PB - American Society for Biochemistry and Molecular Biology
DO - 10.1016/j.jbc.2026.113363
UR - https://doi.org/10.1016/j.jbc.2026.113363
LA - en
ER -

CSL-JSON

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