OSCR

Human TDP-43 expression worsens FTD-related phenotypes in progranulin-insufficient mice.

Overview

Authors: Anna K Cook1,2, Benjamin Lin3, Yumo Song1,4, Kelsey M Greathouse1,2, Azariah K Kaplelach1,2, Mackenzie L Love1,2, Skylar E Davis1,2, Anna C Stoll1,2, Justin A Hall1,2, Ahmad R Hakim1,2, Jakub F Hel1,2, Giacynta A Vollmer1,2, Alexandria C Howard1,2, Noelle H Cooper1,2, Phaedra N Manuel1,2, Juliana M Eberhardt1,2, C Ryan Miller3, Ashley S Harms1,2, Jeremy H Herskowitz1,2, Lindsay F Rizzardi1,4, Andrew E Arrant1,2
ORCID iDs: Azariah K Kaplelach, Giacynta A Vollmer, Lindsay F Rizzardi
  1. Killion Center for Neurodegeneration and Experimental Therapeutics, Alzheimer’s Disease Center, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
  2. Department of Neurology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
  3. Department of Pathology, Division of Neuropathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
  4. Department of Biochemistry and Molecular Genetics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA
Institutions: University of Alabama at Birmingham (United States); UAB Medicine
Journal: Neurobiology of disease, volume 227, article 107475
Dates: published online 8 June 2026; in print September 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.nbd.2026.107475 · PMID 42264399 · PMCID PMC13427247 · OpenAlex W7163892795
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Statistics, Connectivity
Keywords: TDP-43, Progranulin, Frontotemporal dementia
MeSH: DNA-Binding Proteins*, Frontotemporal Dementia*, Progranulins*, Animals, Disease Models, Animal, Humans, Mice, Mice, Transgenic, Phenotype (* major topic)
Topic: Amyotrophic Lateral Sclerosis Research (Neurology, Medicine), according to OpenAlex
Funding: NIA NIH HHS (F30 AG085889, P30 AG086401, R01 AG061800, R01 AG054719); NINDS NIH HHS (T32 NS095775, R01 NS134798, R01 NS128031); National Institute on Aging (R01AG054719, P30AG086401, R01AG061800, F30AG085889); National Institute of Neurological Disorders and Stroke (R01NS134798, T32NS095775, R01NS128031); National Institutes of Health National Cancer Institute (P30CA013148, R01CA258248); NCI NIH HHS (R01 CA258248, P30 CA013148); NIGMS NIH HHS (T32 GM008361); National Institute of General Medical Sciences (T32GM008361)
Citations: not cited yet (Europe PMC); 143 references in the paper
Research resources: GFAP RRID:AB_10013382, pTDP-43 RRID:AB_11182943, NeuN RRID:AB_11205760, c-Fos RRID:AB_2247211, RRID:AB_2935765, CD68 RRID:AB_322219, clone M5/114.15.2 RRID:AB_467562, CD3 RRID:AB_468852, α-tubulin RRID:AB_477579, Ubiquitin RRID:AB_477667, Olig2 RRID:AB_570666, TDP-43 RRID:AB_615042, RRID:IMSR_JAX:012836, Grn+/− mice RRID:MMRRC_036771-JAX

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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Read it in the paper: doi.org/10.1016/j.nbd.2026.107475.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Publisher: — → Elsevier BV

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, pages, dates, 21 authors, 3 keywords, 9 MeSH terms, 8 funders, 138 references, 14 RRIDs.

Cite

This paper

Cook, A. K., Lin, B., Song, Y., Greathouse, K. M., Kaplelach, A. K., Love, M. L., Davis, S. E., Stoll, A. C., Hall, J. A., Hakim, A. R., Hel, J. F., Vollmer, G. A., Howard, A. C., Cooper, N. H., Manuel, P. N., Eberhardt, J. M., Miller, C. R., Harms, A. S., Herskowitz, J. H., . . . Arrant, A. E. (2026). Human TDP-43 expression worsens FTD-related phenotypes in progranulin-insufficient mice. Neurobiology of disease, 227, 107475. https://doi.org/10.1016/j.nbd.2026.107475

BibTeX

@article{cook2026human,
author = {Cook, Anna K and Lin, Benjamin and Song, Yumo and Greathouse, Kelsey M and Kaplelach, Azariah K and Love, Mackenzie L and Davis, Skylar E and Stoll, Anna C and Hall, Justin A and Hakim, Ahmad R and Hel, Jakub F and Vollmer, Giacynta A and Howard, Alexandria C and Cooper, Noelle H and Manuel, Phaedra N and Eberhardt, Juliana M and Miller, C Ryan and Harms, Ashley S and Herskowitz, Jeremy H and Rizzardi, Lindsay F and Arrant, Andrew E},
title = {{Human TDP-43 expression worsens FTD-related phenotypes in progranulin-insufficient mice}},
journal = {Neurobiology of disease},
year = {2026},
month = jun,
volume = {227},
pages = {107475},
publisher = {Elsevier BV},
issn = {0969-9961},
doi = {10.1016/j.nbd.2026.107475},
url = {https://doi.org/10.1016/j.nbd.2026.107475},
pmid = {42264399},
pmcid = {PMC13427247}
}

RIS

TY - JOUR
AU - Cook, Anna K
AU - Lin, Benjamin
AU - Song, Yumo
AU - Greathouse, Kelsey M
AU - Kaplelach, Azariah K
AU - Love, Mackenzie L
AU - Davis, Skylar E
AU - Stoll, Anna C
AU - Hall, Justin A
AU - Hakim, Ahmad R
AU - Hel, Jakub F
AU - Vollmer, Giacynta A
AU - Howard, Alexandria C
AU - Cooper, Noelle H
AU - Manuel, Phaedra N
AU - Eberhardt, Juliana M
AU - Miller, C Ryan
AU - Harms, Ashley S
AU - Herskowitz, Jeremy H
AU - Rizzardi, Lindsay F
AU - Arrant, Andrew E
TI - Human TDP-43 expression worsens FTD-related phenotypes in progranulin-insufficient mice
T2 - Neurobiology of disease
J2 - Neurobiol Dis
PY - 2026
DA - 2026/06/08
VL - 227
SP - 107475
SN - 0969-9961
PB - Elsevier BV
DO - 10.1016/j.nbd.2026.107475
UR - https://doi.org/10.1016/j.nbd.2026.107475
LA - en
ER -

CSL-JSON

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