Analysis of GRK2 aggregation in the pathology of Alzheimer disease in animal models.
Overview
- Molecular Pharmacology, ETH Zurich, 8057 Zurich, Switzerland
- Department of Pharmaceutical Sciences, University of Vienna, 1090 Vienna, Austria
- Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
- Medical Research Center (MRC), Ain Shams University Hospitals, Cairo 11566, Egypt
- Institute of Pharmacology and Toxicology, University of Zurich, 8057 Zurich, Switzerland
Abstract
The G-protein-coupled receptor kinase 2 (GRK2) exerts essential functions in cell growth and survival. Searching for a connection between GRK2 and the neurodegenerative Alzheimer disease (AD), we find increased aggregated serine-670-phosphorylate
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.
The paper's code and data availability statement is in the Data section.
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Data
Datasets cited
- alphafold.ebi.ac.uk/
entry/ , at EMBL-EBI; found in the resources tableq96b49 - geo:GSE317145, at NCBI GEO; found in “Data and code availability”
Data and code availability
Whole-genome microarray gene expression data have been deposited to NCBI GEO: GSE317145 (https://
Data analyzed and reported have been deposited in the online repository ETH Zurich Research Collection (https://
No custom code was generated in this study.
Any additional information required to reanalyze the data reported in this paper is available from the lead contact upon request.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 7 keywords, 15 MeSH terms, 2 funders, 75 references, 23 RRIDs.
Cite
This paper
Abd Alla, J., Perhal, A., Fu, X., Langer, A., Faramawy, Y. e., & Quitterer, U. (2026). Analysis of GRK2 aggregation in the pathology of Alzheimer disease in animal models. Cell reports. Medicine, 7(4), 102707. https://
BibTeX
@article{abdalla2026anal
author = {Abd Alla, Joshua and Perhal, Alexander and Fu, Xuebin and Langer, Andreas and Faramawy, Yasser el and Quitterer, Ursula},
title = {{Analysis of GRK2 aggregation in the pathology of Alzheimer disease in animal models}},
journal = {Cell reports. Medicine},
year = {2026},
month = mar,
volume = {7},
number = {4},
pages = {102707},
publisher = {Elsevier},
issn = {2666-3791},
doi = {10.1016/
url = {https://
pmid = {41895286},
pmcid = {PMC13130637}
}
RIS
TY - JOUR
AU - Abd Alla, Joshua
AU - Perhal, Alexander
AU - Fu, Xuebin
AU - Langer, Andreas
AU - Faramawy, Yasser el
AU - Quitterer, Ursula
TI - Analysis of GRK2 aggregation in the pathology of Alzheimer disease in animal models
T2 - Cell reports. Medicine
J2 - Cell Rep Med
PY - 2026
DA - 2026/
VL - 7
IS - 4
SP - 102707
SN - 2666-3791
PB - Elsevier
DO - 10.1016/
UR - https://
LA - en
ER -
CSL-JSON
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