BDNF insufficiency exacerbates ALS progression.
Overview
- School of Pharmaceutical Sciences and IDG/McGovern Institute for Brain Research, Tsinghua University, Beijing 100084, China
- Department of Neurology, Peking University Third Hospital, Beijing 100044, China
- Changping Laboratory, Beijing 102206, China
- Department of Neurology and National Center for Neurological Disorders, Huashan Hospital, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai 200032, China
- Tsinghua-Peking Joint Center for Life Sciences and School of Medicine, Tsinghua University, Beijing 100084, China
- 4B Technologies, Limited, Suzhou 215123, China
- School of Public Health, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310053, China
- Neuroscience Research Institute and Department of Neurobiology, School of Basic Medical Sciences, Peking University, Key Laboratory for Neuroscience, Ministry of Education of China and National Health Commission of the People’s Republic of China, Beijing 100083, China
- Beijing Municipal Key Laboratory of Biomarker and Translational Research in Neurodegenerative Diseases, Beijing 100191, China
- Institute for Translational Brain Research, Center for Clinical Neuro-AI, MOE Frontiers Center for Brain Science, Fudan University, Shanghai 200032, China
- Institute of Biomedical Sciences, Fudan University, Shanghai 200032, China
- Shanghai Academy of Natural Sciences, Shanghai 200031, China
Abstract
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with progressive loss of motor neurons. Insufficiency of neurotrophic factors is suspected to underlie the disease, but direct evidence remains scarce. In this study, we discover that brain-derived neurotrophic factor (BDNF) val/
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
Code
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Data and code availability
• The clinical data from this study are not publicly available due to patient privacy considerations. To request access to the data, please contact the lead contact. Data access will be considered for non-commercial, research-oriented purposes only. All data access requests must adhere to the consent agreements established with study participants and comply with all applicable institutional and national regulations. • This study does not report original code. • Any additional information required to reanalyze the data reported in this work paper is available from the lead contact upon request.
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
Versions
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Version 1, 29 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 13 authors, 1 keyword, 13 MeSH terms, 8 funders, 57 references, 9 RRIDs.
Cite
This paper
Xu, Y., He, J., Wang, S., Ge, Y., Jia, Y., Guo, W., Lv, C., Yao, X., Mao, Y., Mei, F., Fan, D., Yuan, P., & Lu, B. (2026). BDNF insufficiency exacerbates ALS progression. Cell reports. Medicine, 7(5), 102758. https://
BibTeX
@article{xu2026bdnf,
author = {Xu, Yihua and He, Ji and Wang, Shudan and Ge, Yijun and Jia, Yichang and Guo, Wei and Lv, Chen and Yao, Xinmeng and Mao, Yingying and Mei, Fan and Fan, Dongsheng and Yuan, Peng and Lu, Bai},
title = {{BDNF insufficiency exacerbates ALS progression}},
journal = {Cell reports. Medicine},
year = {2026},
month = apr,
volume = {7},
number = {5},
pages = {102758},
publisher = {Elsevier},
issn = {2666-3791},
doi = {10.1016/
url = {https://
pmid = {42013845},
pmcid = {PMC13198251}
}
RIS
TY - JOUR
AU - Xu, Yihua
AU - He, Ji
AU - Wang, Shudan
AU - Ge, Yijun
AU - Jia, Yichang
AU - Guo, Wei
AU - Lv, Chen
AU - Yao, Xinmeng
AU - Mao, Yingying
AU - Mei, Fan
AU - Fan, Dongsheng
AU - Yuan, Peng
AU - Lu, Bai
TI - BDNF insufficiency exacerbates ALS progression
T2 - Cell reports. Medicine
J2 - Cell Rep Med
PY - 2026
DA - 2026/
VL - 7
IS - 5
SP - 102758
SN - 2666-3791
PB - Elsevier
DO - 10.1016/
UR - https://
LA - en
ER -
CSL-JSON
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