Multi-Target Neuroprotective Compound Exhibits EAAT2-Modulating and Alzheimer's Pathology-Attenuating Effects in In Vitro and In Vivo Models.
Overview
- Department of Medical Pharmacology, Faculty of Medicine, Atatürk University, 25240 Erzurum, Turkey
- Department of Chemistry, Faculty of Sciences, Atatürk University, 25240 Erzurum, Turkey
- Biotechnology Institute, Ankara University, 06135 Ankara, Turkey
- Trustlife Laboratories Drug Research & Development Center, 34774 İstanbul, Turkey
- Biochemistry Department, Faculty of Pharmacy, Istanbul Health and Technology University, Sütlüce, Beyoğlu, 34275 İstanbul, Turkey
- Faculty of Veterinary Medicine, Department of Pathology, Cumhuriyet University, 58140 Sivas, Turkey
- Department of Eye Diseases, Faculty of Medicine, Atatürk University, 25240 Erzurum, Turkey
- Department of Medical Pharmacology, Faculty of Medicine, Bilecik Seyh Edebali University, 11230 Bilecik, Turkey
- Department of Medical Biology, Faculty of Medicine, Atatürk University, 25240 Erzurum, Turkey
Abstract
Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder characterized by cognitive decline and memory loss. Current treatments offer limited efficacy, necessitating the development of innovative multitarget therapeutic strategies. Here, we present N 3,N 5-bis(2-(5-methoxy-1H-i
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Data
Datasets cited
- rcsb.org/
structure/ , at PDB; found in the text, “Molecular Docking (MD)”7xr4
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 19 authors, 5 keywords, 15 MeSH terms, 94 references.
Cite
This paper
Hacımüftüoğlu, A., Saraçoğlu, N., Saffour, S., Abad, N., Kesgun, Y., Zegheb, N., Gundeger, E., Yeşilyurt, F., Ataş, M. N., Bati-Ayaz, G., Altunlu, Ö., Çınar, B., Yörük, M. A., Okkay, U., Özkaraca, M., Ateş, O., Taghizadehghalehjoughi, A., Lafzi, F., & Türkez, H. (2026). Multi-Target Neuroprotective Compound Exhibits EAAT2-Modulating and Alzheimer's Pathology-Attenuating Effects in In Vitro and In Vivo Models. ACS chemical neuroscience, 17(10), 1919-1944. https://
BibTeX
@article{hacmuftuoglu202
author = {Hacımüftüoğlu, Ahmet and Saraçoğlu, Nurullah and Saffour, Sana and Abad, Nadeem and Kesgun, Yunus and Zegheb, Nadjiba and Gundeger, Ersin and Yeşilyurt, Fatma and Ataş, Merve Nur and Bati-Ayaz, Gizem and Altunlu, Öznur and Çınar, Burak and Yörük, Mehmet Ali and Okkay, Ufuk and Özkaraca, Mustafa and Ateş, Orhan and Taghizadehghalehjoughi, Ali and Lafzi, Ferruh and Türkez, Hasan},
title = {{Multi-Target Neuroprotective Compound Exhibits EAAT2-Modulating and Alzheimer's Pathology-Attenuating Effects in In Vitro and In Vivo Models}},
journal = {ACS chemical neuroscience},
year = {2026},
month = apr,
volume = {17},
number = {10},
pages = {1919--1944},
publisher = {American Chemical Society},
issn = {1948-7193},
doi = {10.1021/
url = {https://
pmid = {42051019},
pmcid = {PMC13195668}
}
RIS
TY - JOUR
AU - Hacımüftüoğlu, Ahmet
AU - Saraçoğlu, Nurullah
AU - Saffour, Sana
AU - Abad, Nadeem
AU - Kesgun, Yunus
AU - Zegheb, Nadjiba
AU - Gundeger, Ersin
AU - Yeşilyurt, Fatma
AU - Ataş, Merve Nur
AU - Bati-Ayaz, Gizem
AU - Altunlu, Öznur
AU - Çınar, Burak
AU - Yörük, Mehmet Ali
AU - Okkay, Ufuk
AU - Özkaraca, Mustafa
AU - Ateş, Orhan
AU - Taghizadehghalehjoughi, Ali
AU - Lafzi, Ferruh
AU - Türkez, Hasan
TI - Multi-Target Neuroprotective Compound Exhibits EAAT2-Modulating and Alzheimer's Pathology-Attenuating Effects in In Vitro and In Vivo Models
T2 - ACS chemical neuroscience
J2 - ACS Chem Neurosci
PY - 2026
DA - 2026/
VL - 17
IS - 10
SP - 1919
EP - 1944
SN - 1948-7193
PB - American Chemical Society
DO - 10.1021/
UR - https://
LA - en
ER -
CSL-JSON
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