"Behavioral and Neuroinflammatory Evaluation of a Novel Isoxazole-5-One Derivative in Animal Models of Alzheimer's Disease via TNF-α, COX-2, IL-6, and NF-κB Modulation".

Overview

Authors: Nitasha Gohar^1,2, Muzaffar Abbas², Syed Muzzammil Masaud^1,3, Iqra Zulfiqar², Hafsa Jabeen², Nadia Shamshad Malik², Humaira Nadeem¹

ORCID iDs: Nitasha Gohar, Muzaffar Abbas, Humaira Nadeem

Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 44000, Pakistan
Capital University of Science and Technology, Islamabad 44000, Pakistan
Department of Allied Health Sciences, The Saifee Burhani University, Karachi 74000, Pakistan

Institutions: Riphah International University (Pakistan); Capital University of Science and Technology (Pakistan)

Journal: ACS omega, volume 11, issue 27, pages 39910-39921

Dates: received 29 January 2026; accepted 15 June 2026; published online 29 June 2026

Type: Research article · Language: English

License: CC BY-NC-ND

Identifiers: DOI 10.1021/acsomega.6c01108 · PMID 42518426 · PMCID PMC13382720 · OpenAlex W7166549212

Open access: gold, a free copy (OpenAlex)

Status: data only

Categories: behavior only (modality), Alzheimer's / dementia (population), cellular / molecular (subfield)

Methods: Statistics, Graphs

Topic: Alzheimer's disease research and treatments (Physiology, Medicine), according to OpenAlex

Citations: not cited yet (Europe PMC); 88 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none, so it has no map.

Data

Datasets cited

rcsb.org/structure/1p9m, at PDB; found in the text, “Materials and Methods”
rcsb.org/structure/1vkx, at PDB; found in the text, “Materials and Methods”
rcsb.org/structure/2az5, at PDB; found in the text, “Materials and Methods”
rcsb.org/structure/4ey7, at PDB; found in the text, “Materials and Methods”
rcsb.org/structure/5kir, at PDB; found in the text, “Materials and Methods”

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 82 references.

Cite

This paper

Gohar, N., Abbas, M., Masaud, S. M., Zulfiqar, I., Jabeen, H., Malik, N. S., & Nadeem, H. (2026). "Behavioral and Neuroinflammatory Evaluation of a Novel Isoxazole-5-One Derivative in Animal Models of Alzheimer's Disease via TNF-α, COX-2, IL-6, and NF-κB Modulation". ACS omega, 11(27), 39910-39921. https://doi.org/10.1021/acsomega.6c01108

BibTeX

@article{gohar2026behavioral, author = {Gohar, Nitasha and Abbas, Muzaffar and Masaud, Syed Muzzammil and Zulfiqar, Iqra and Jabeen, Hafsa and Malik, Nadia Shamshad and Nadeem, Humaira}, title = {{"Behavioral and Neuroinflammatory Evaluation of a Novel Isoxazole-5-One Derivative in Animal Models of Alzheimer's Disease via TNF-α, COX-2, IL-6, and NF-κB Modulation"}}, journal = {ACS omega}, year = {2026}, month = jun, volume = {11}, number = {27}, pages = {39910--39921}, publisher = {American Chemical Society}, issn = {2470-1343}, doi = {10.1021/acsomega.6c01108}, url = {https://doi.org/10.1021/acsomega.6c01108}, pmid = {42518426}, pmcid = {PMC13382720} }

RIS

TY - JOUR AU - Gohar, Nitasha AU - Abbas, Muzaffar AU - Masaud, Syed Muzzammil AU - Zulfiqar, Iqra AU - Jabeen, Hafsa AU - Malik, Nadia Shamshad AU - Nadeem, Humaira TI - "Behavioral and Neuroinflammatory Evaluation of a Novel Isoxazole-5-One Derivative in Animal Models of Alzheimer's Disease via TNF-α, COX-2, IL-6, and NF-κB Modulation" T2 - ACS omega J2 - ACS Omega PY - 2026 DA - 2026/06/29 VL - 11 IS - 27 SP - 39910 EP - 39921 SN - 2470-1343 PB - American Chemical Society DO - 10.1021/acsomega.6c01108 UR - https://doi.org/10.1021/acsomega.6c01108 LA - en ER -

CSL-JSON

{ "id": "10.1021/acsomega.6c01108", "type": "article-journal", "title": "\"Behavioral and Neuroinflammatory Evaluation of a Novel Isoxazole-5-One Derivative in Animal Models of Alzheimer's Disease via TNF-α, COX-2, IL-6, and NF-κB Modulation\"", "container-title": "ACS omega", "author": [ { "family": "Gohar", "given": "Nitasha" }, { "family": "Abbas", "given": "Muzaffar" }, { "family": "Masaud", "given": "Syed Muzzammil" }, { "family": "Zulfiqar", "given": "Iqra" }, { "family": "Jabeen", "given": "Hafsa" }, { "family": "Malik", "given": "Nadia Shamshad" }, { "family": "Nadeem", "given": "Humaira" } ], "container-title-short": "ACS Omega", "volume": "11", "issue": "27", "page": "39910-39921", "DOI": "10.1021/acsomega.6c01108", "PMID": "42518426", "PMCID": "PMC13382720", "ISSN": "2470-1343", "publisher": "American Chemical Society", "URL": "https://doi.org/10.1021/acsomega.6c01108", "language": "en", "issued": { "date-parts": [ [ 2026, 6, 29 ] ] } }

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