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Human iPSC-derived GABAergic interneuron transplantation restores circuit balance and cognitive function in an Alzheimer's disease model.

A correction to this paper has been published: the notice, 42764448, from Europe PMC.

Overview

Authors: Xinzhe Zhang1,2, Gaojie Wang1, Haodong Chen1, Ye Sun1, Ziteng Wangliu1, Lijing Wang1,3, Miao Sun2,3, Qing Liu1,3, Xue Zhang2,3
ORCID iDs: Qing Liu
  1. Department of Neurology, Peking Union Medical College Hospital (PUMCH), Peking Union Medical College (PUMC) & Chinese Academy of Medical Science(CAMS), Beijing, China
  2. Mckusick‐Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, PUMC & CAMS, Beijing, China
  3. State Key Laboratory of Complex, Severe, and Rare Diseases, PUMCH, Beijing, China
Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association, volume 22, issue 4, article e71378
Dates: received 26 October 2025; accepted 11 March 2026; published online 27 April 2026; in print April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1002/alz.71378 · PMID 42043780 · PMCID PMC13116222 · OpenAlex W7156007589
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), Alzheimer's / dementia (population)
Methods: Preprocessing, Statistics
Keywords: Alzheimer's disease, cell therapy, cognitive function, excitatory–inhibitory balance, medial ganglionic eminence
MeSH: Alzheimer Disease*, Cognition*, GABAergic Neurons*, Induced Pluripotent Stem Cells*, Interneurons*, Animals, Disease Models, Animal, Ganglionic Eminence, Hippocampus, Humans, Mice, Mice, Transgenic (* major topic)
Topic: Neurogenesis and neuroplasticity mechanisms (Developmental Neuroscience, Neuroscience), according to OpenAlex
Funding: National Key Research and Development Program (2022YFC2503804, 2022YFC2703900); Chinese Academy of Medical Sciences; Innovation Fund for Medical Sciences (2021-I2M-1-018, 2021-I2M-1-034); National Key Research and Development Program of China (2022YFC2503804, 2022YFC2703900); PUMCH Talent Cultivation Program (UBJ10405)
Citations: not cited yet (Europe PMC); 67 references in the paper
Research resources: 5xFAD transgenic mice RRID:MMRRC_034848
Notices: A correction to this paper has been published (42764448, from Europe PMC)

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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Read it in the paper: doi.org/10.1002/alz.71378.

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 5 keywords, 12 MeSH terms, 5 funders, 67 references, 1 RRID, 1 integrity notice.

Cite

This paper

Zhang, X., Wang, G., Chen, H., Sun, Y., Wangliu, Z., Wang, L., Sun, M., Liu, Q., & Zhang, X. (2026). Human iPSC-derived GABAergic interneuron transplantation restores circuit balance and cognitive function in an Alzheimer's disease model. Alzheimer's & dementia : the journal of the Alzheimer's Association, 22(4), e71378. https://doi.org/10.1002/alz.71378

BibTeX

@article{zhang2026human,
author = {Zhang, Xinzhe and Wang, Gaojie and Chen, Haodong and Sun, Ye and Wangliu, Ziteng and Wang, Lijing and Sun, Miao and Liu, Qing and Zhang, Xue},
title = {{Human iPSC-derived GABAergic interneuron transplantation restores circuit balance and cognitive function in an Alzheimer's disease model}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2026},
month = apr,
volume = {22},
number = {4},
pages = {e71378},
publisher = {Wiley},
issn = {1552-5260},
doi = {10.1002/alz.71378},
url = {https://doi.org/10.1002/alz.71378},
pmid = {42043780},
pmcid = {PMC13116222}
}

RIS

TY - JOUR
AU - Zhang, Xinzhe
AU - Wang, Gaojie
AU - Chen, Haodong
AU - Sun, Ye
AU - Wangliu, Ziteng
AU - Wang, Lijing
AU - Sun, Miao
AU - Liu, Qing
AU - Zhang, Xue
TI - Human iPSC-derived GABAergic interneuron transplantation restores circuit balance and cognitive function in an Alzheimer's disease model
T2 - Alzheimer's & dementia : the journal of the Alzheimer's Association
J2 - Alzheimers Dement
PY - 2026
DA - 2026/04/01
VL - 22
IS - 4
SP - e71378
SN - 1552-5260
PB - Wiley
DO - 10.1002/alz.71378
UR - https://doi.org/10.1002/alz.71378
LA - en
ER -

CSL-JSON

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