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Prostaglandin E<sub>2</sub>-driven dedifferentiation of Schwann cells leads to perineural invasion in pancreatic ductal adenocarcinoma.

Overview

Authors: Ling Wang1, Qicai Liu2,3,4, Zhibo Zhang5, Shizhong Yang3, Juan Tang1, Guobin Pan2, Yuqing Zheng1, Yuting Zhuang1, Qiming Wu6, Shangeng Weng5, Feng Gao1,7, Jiahong Dong3,8
ORCID iDs: Qicai Liu, Feng Gao
  1. Department of Pathology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, P. R. China
  2. Department of Reproductive Medicine Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou, P. R. China
  3. Hepatopancreatobiliary Center, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, P. R. China
  4. School of Biomedical Engineering, Tsinghua University, Beijing, P. R. China
  5. Department of Hepatopancreatobiliary Surgery, The First Affiliated Hospital, Fujian Medical University, Fuzhou, P. R. China
  6. Department of Hepatobiliary Surgery, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, P. R. China
  7. Department of Pathology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fujian, P. R. China
  8. Key Laboratory of Digital Intelligence Hepatology (Ministry of Education), Tsinghua University, Beijing, P. R. China
Institutions: Fujian Medical University (China); First Affiliated Hospital of Fujian Medical University (China); Beijing Tsinghua Chang Gung Hospital (China); Tsinghua University (China); Mengchao Hepatobiliary Hospital (China)
Journal: Signal transduction and targeted therapy, volume 11, issue 1, article 122
Dates: received 31 August 2025; accepted 12 February 2026; published online 7 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41392-026-02648-x · PMID 41946682 · PMCID PMC13056918 · OpenAlex W7151401276
Open access: gold, a free copy (OpenAlex)
Status: data only (how the code is found and verified)
Categories: human (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, fMRI & imaging
Keywords: Gastrointestinal cancer
MeSH: Carcinoma, Pancreatic Ductal*, Cell Dedifferentiation*, Dinoprostone*, Pancreatic Neoplasms*, Schwann Cells*, ADAMTS1 Protein, Cell Line, Tumor, Gene Expression Regulation, Neoplastic, Humans, Neoplasm Invasiveness, SOXB1 Transcription Factors (* major topic)
Topic: Pancreatic and Hepatic Oncology Research (Oncology, Medicine), according to OpenAlex
Funding: National Natural Science Foundation of China (National Science Foundation of China) (82172953, 81871293, 82090053)
Citations: cited by 1 paper (Europe PMC); 43 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Data availability statement

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  • it says that the data are available on request

Read it in the paper: doi.org/10.1038/s41392-026-02648-x.

Versions

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Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 1 keyword, 11 MeSH terms, 1 funder, 43 references.

Cite

This paper

Wang, L., Liu, Q., Zhang, Z., Yang, S., Tang, J., Pan, G., Zheng, Y., Zhuang, Y., Wu, Q., Weng, S., Gao, F., & Dong, J. (2026). Prostaglandin E<sub>2</sub>-driven dedifferentiation of Schwann cells leads to perineural invasion in pancreatic ductal adenocarcinoma. Signal transduction and targeted therapy, 11(1), 122. https://doi.org/10.1038/s41392-026-02648-x

BibTeX

@article{wang2026prostaglandin,
author = {Wang, Ling and Liu, Qicai and Zhang, Zhibo and Yang, Shizhong and Tang, Juan and Pan, Guobin and Zheng, Yuqing and Zhuang, Yuting and Wu, Qiming and Weng, Shangeng and Gao, Feng and Dong, Jiahong},
title = {{Prostaglandin E\<sub\>2\</sub\>-driven dedifferentiation of Schwann cells leads to perineural invasion in pancreatic ductal adenocarcinoma}},
journal = {Signal transduction and targeted therapy},
year = {2026},
month = apr,
volume = {11},
number = {1},
pages = {122},
publisher = {Nature Publishing Group},
issn = {2095-9907},
doi = {10.1038/s41392-026-02648-x},
url = {https://doi.org/10.1038/s41392-026-02648-x},
pmid = {41946682},
pmcid = {PMC13056918}
}

RIS

TY - JOUR
AU - Wang, Ling
AU - Liu, Qicai
AU - Zhang, Zhibo
AU - Yang, Shizhong
AU - Tang, Juan
AU - Pan, Guobin
AU - Zheng, Yuqing
AU - Zhuang, Yuting
AU - Wu, Qiming
AU - Weng, Shangeng
AU - Gao, Feng
AU - Dong, Jiahong
TI - Prostaglandin E<sub>2</sub>-driven dedifferentiation of Schwann cells leads to perineural invasion in pancreatic ductal adenocarcinoma
T2 - Signal transduction and targeted therapy
J2 - Signal Transduct Target Ther
PY - 2026
DA - 2026/04/07
VL - 11
IS - 1
SP - 122
SN - 2095-9907
PB - Nature Publishing Group
DO - 10.1038/s41392-026-02648-x
UR - https://doi.org/10.1038/s41392-026-02648-x
LA - en
ER -

CSL-JSON

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