OSCR

Tumor-derived GDF15 induces CCN3⁺ Schwann cells to promote cancer pain in pancreatic cancer.

Overview

Authors: Guojun Chen1, Weicheng Lu1, Meng Liu2, Qingqing Ye1, Yixin Xu1, Yanqun Zhang1, Xiangna Guo1, Yaqi Ye1, Xiaohua Yang1,3, Xiaolin Luo1, Wenjun Xin3,4, Jingdun Xie1
ORCID iDs: Guojun Chen, Xiaolin Luo, Wenjun Xin, Jingdun Xie
  1. Department of Anesthesiology, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China
  2. Department of Anesthesia and Pain Medicine, Guangzhou First People’s Hospital, Guangzhou, China
  3. Guangdong Province Key Laboratory of Brain Function and Disease, Department of Physiology and Pain Research Center, Zhongshan Medical School, Sun Yat-sen University, Zhongshan Road 2, Guangzhou, China
  4. Key Laboratory for Molecular Genetic Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi China
Institutions: Sun Yat-sen University Cancer Center (China); State Key Laboratory of Oncology in South China; Guangzhou First People's Hospital (China); Sun Yat-sen University (China); Xizang Minzu University (China)
Journal: Nature communications, volume 17, issue 1, article 6328
Dates: received 9 August 2025; accepted 24 April 2026; published online 12 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-72932-5 · PMID 42120379 · PMCID PMC13376396 · OpenAlex W7160938190
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), other condition (population), pain (population), cellular / molecular (subfield)
Methods: Statistics
Keywords: Neuroscience, Cancer
MeSH: Carcinoma, Pancreatic Ductal*, Pain*, Pancreatic Neoplasms*, Schwann Cells*, Animals, Cell Line, Tumor, Glial Cell Line-Derived Neurotrophic Factor Receptors, Glycolysis, Humans, Metabolic Reprogramming, Mice, Signal Transduction, Tumor Microenvironment (* major topic)
Topic: Connective Tissue Growth Factor Research (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Natural Science Foundation of China (National Science Foundation of China) (82471238, 824B2028 and 82401446)
Citations: cited by 1 paper (Europe PMC); 87 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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Read it in the paper: doi.org/10.1038/s41467-026-72932-5.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 2 keywords, 13 MeSH terms, 1 funder, 86 references.

Cite

This paper

Chen, G., Lu, W., Liu, M., Ye, Q., Xu, Y., Zhang, Y., Guo, X., Ye, Y., Yang, X., Luo, X., Xin, W., & Xie, J. (2026). Tumor-derived GDF15 induces CCN3⁺ Schwann cells to promote cancer pain in pancreatic cancer. Nature communications, 17(1), 6328. https://doi.org/10.1038/s41467-026-72932-5

BibTeX

@article{chen2026tumor,
author = {Chen, Guojun and Lu, Weicheng and Liu, Meng and Ye, Qingqing and Xu, Yixin and Zhang, Yanqun and Guo, Xiangna and Ye, Yaqi and Yang, Xiaohua and Luo, Xiaolin and Xin, Wenjun and Xie, Jingdun},
title = {{Tumor-derived GDF15 induces CCN3⁺ Schwann cells to promote cancer pain in pancreatic cancer}},
journal = {Nature communications},
year = {2026},
month = may,
volume = {17},
number = {1},
pages = {6328},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-72932-5},
url = {https://doi.org/10.1038/s41467-026-72932-5},
pmid = {42120379},
pmcid = {PMC13376396}
}

RIS

TY - JOUR
AU - Chen, Guojun
AU - Lu, Weicheng
AU - Liu, Meng
AU - Ye, Qingqing
AU - Xu, Yixin
AU - Zhang, Yanqun
AU - Guo, Xiangna
AU - Ye, Yaqi
AU - Yang, Xiaohua
AU - Luo, Xiaolin
AU - Xin, Wenjun
AU - Xie, Jingdun
TI - Tumor-derived GDF15 induces CCN3⁺ Schwann cells to promote cancer pain in pancreatic cancer
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/05/12
VL - 17
IS - 1
SP - 6328
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-72932-5
UR - https://doi.org/10.1038/s41467-026-72932-5
LA - en
ER -

CSL-JSON

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"container-title-short": "Nat Commun",
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"PMID": "42120379",
"PMCID": "PMC13376396",
"ISSN": "2041-1723",
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"language": "en",
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