Transcriptomic analysis reveals that neural stem cell-derived exosomes regulate the HMGB1/TLR2 signaling axis to promote astrocytic differentiation and mitochondrial biogenesis in the repair of radiation-induced blood-brain barrier damage.
Overview
- Department of Radiation Oncology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
- Department of Thoracic Oncology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
- Guangzhou Medical University, Guangzhou, China
- Jiangxi University of Traditional Chinese Medicine, Nanchang, China
- Department of Medical Oncology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Abstract
Radiation-induced brain injury (RBI) is frequently associated with blood–brain barrier (BBB) disruption, which contributes to poor prognosis. Neural stem cell-derived exosomes (NSC-Exo) have recently attracted attention as mediators of intercellular communication with potential roles in tissue repair. However, how NSC-Exo promote BBB recovery after RBI remains unclear. This study explored whether NSC-Exo restore BBB function by regulating the HMGB1/
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- bioproject:PRJNA1463563, at NCBI BioProject; found in “Data availability”
Data availability
The RNA-seq data generated in this study have been deposited in the NCBI BioProject database under accession number PRJNA1463563 (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 2 keywords, 51 references.
Cite
This paper
Zeng, F., Zhang, Y., Zhou, Y., Ma, Z., Li, C., Yao, G., & Li, R. (2026). Transcriptomic analysis reveals that neural stem cell-derived exosomes regulate the HMGB1/
BibTeX
@article{zeng2026transcr
author = {Zeng, Fanrui and Zhang, Yalei and Zhou, Yun and Ma, Zichen and Li, Chenghao and Yao, Guohua and Li, Rong},
title = {{Transcriptomic analysis reveals that neural stem cell-derived exosomes regulate the HMGB1/
journal = {Cell death discovery},
year = {2026},
month = jul,
volume = {12},
number = {1},
pages = {373},
publisher = {Nature Publishing Group},
issn = {2058-7716},
doi = {10.1038/
url = {https://
pmid = {42736277},
pmcid = {PMC13575103}
}
RIS
TY - JOUR
AU - Zeng, Fanrui
AU - Zhang, Yalei
AU - Zhou, Yun
AU - Ma, Zichen
AU - Li, Chenghao
AU - Yao, Guohua
AU - Li, Rong
TI - Transcriptomic analysis reveals that neural stem cell-derived exosomes regulate the HMGB1/
T2 - Cell death discovery
J2 - Cell Death Discov
PY - 2026
DA - 2026/
VL - 12
IS - 1
SP - 373
SN - 2058-7716
PB - Nature Publishing Group
DO - 10.1038/
UR - https://
LA - en
ER -
CSL-JSON
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