OSCR

miR‑223‑3p promotes microglial lactylation and M1 polarization via the FBXW7/Notch1/Hes1/SIRT1 axis.

Overview

Authors: Xiaoyu Wang1, Lin Song1,2,3, Jiafeng Wang1, Qianqian Xie1, Yan Wang1, Chunyan Li1, Tianqi Wang4, Yifeng Du1,2,3,5
ORCID iDs: Yifeng Du
  1. Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, P.R. China
  2. Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong 250021, P.R. China
  3. Shandong Provincial Clinical Research Center for Neurological Diseases, Jinan, Shandong 250021, P.R. China
  4. Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, P.R. China
  5. Institute of Brain Science and Brain-Inspired Research, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, P.R. China
Journal: International journal of molecular medicine, volume 58, issue 1, article 178
Dates: received 26 November 2025; accepted 22 April 2026; published online 8 May 2026; in print July 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.3892/ijmm.2026.5849 · PMID 42138198 · PMCID PMC13170779 · OpenAlex W7160662771
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: human (organism), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Preprocessing, Statistics
Keywords: lactylation, microglial M1 polarization, Alzheimer's disease, microRNA-223-3p, SIRT1
MeSH: F-Box-WD Repeat-Containing Protein 7*, Microglia*, MicroRNAs*, Receptor, Notch1*, Signal Transduction*, Sirtuin 1*, Transcription Factor HES-1*, Alzheimer Disease, Animals, Cell Polarity, Humans, Reactive Oxygen Species (* major topic)
Topic: Sirtuins and Resveratrol in Medicine (Geriatrics and Gerontology, Medicine), according to OpenAlex
Funding: STI2030-Major Project (2021ZD0201808, 2022ZD0211600); Academic Promotion Program of Shandong First Medical University (2019QL020, 2020RC009); Natural Science Foundation of Shandong (ZR2024MH225); Taishan Scholar Program of Shandong (ts20190977, Tsqn201909182)
Citations: not cited yet (Europe PMC); 47 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none, so it has no map.

Data

Data links

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • no repository, dataset or request procedure was recognized in it

Read it in the paper: doi.org/10.3892/ijmm.2026.5849.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 5 keywords, 12 MeSH terms, 4 funders, 47 references.

Cite

This paper

Wang, X., Song, L., Wang, J., Xie, Q., Wang, Y., Li, C., Wang, T., & Du, Y. (2026). miR‑223‑3p promotes microglial lactylation and M1 polarization via the FBXW7/Notch1/Hes1/SIRT1 axis. International journal of molecular medicine, 58(1), 178. https://doi.org/10.3892/ijmm.2026.5849

BibTeX

@article{wang2026mir2233p,
author = {Wang, Xiaoyu and Song, Lin and Wang, Jiafeng and Xie, Qianqian and Wang, Yan and Li, Chunyan and Wang, Tianqi and Du, Yifeng},
title = {{miR‑223‑3p promotes microglial lactylation and M1 polarization via the FBXW7/Notch1/Hes1/SIRT1 axis}},
journal = {International journal of molecular medicine},
year = {2026},
month = may,
volume = {58},
number = {1},
pages = {178},
publisher = {Spandidos Publications},
issn = {1107-3756},
doi = {10.3892/ijmm.2026.5849},
url = {https://doi.org/10.3892/ijmm.2026.5849},
pmid = {42138198},
pmcid = {PMC13170779}
}

RIS

TY - JOUR
AU - Wang, Xiaoyu
AU - Song, Lin
AU - Wang, Jiafeng
AU - Xie, Qianqian
AU - Wang, Yan
AU - Li, Chunyan
AU - Wang, Tianqi
AU - Du, Yifeng
TI - miR‑223‑3p promotes microglial lactylation and M1 polarization via the FBXW7/Notch1/Hes1/SIRT1 axis
T2 - International journal of molecular medicine
J2 - Int J Mol Med
PY - 2026
DA - 2026/05/15
VL - 58
IS - 1
SP - 178
SN - 1107-3756
PB - Spandidos Publications
DO - 10.3892/ijmm.2026.5849
UR - https://doi.org/10.3892/ijmm.2026.5849
LA - en
ER -

CSL-JSON

{
"id": "10.3892/ijmm.2026.5849",
"type": "article-journal",
"title": "miR‑223‑3p promotes microglial lactylation and M1 polarization via the FBXW7/Notch1/Hes1/SIRT1 axis",
"container-title": "International journal of molecular medicine",
"author": [
{
"family": "Wang",
"given": "Xiaoyu"
},
{
"family": "Song",
"given": "Lin"
},
{
"family": "Wang",
"given": "Jiafeng"
},
{
"family": "Xie",
"given": "Qianqian"
},
{
"family": "Wang",
"given": "Yan"
},
{
"family": "Li",
"given": "Chunyan"
},
{
"family": "Wang",
"given": "Tianqi"
},
{
"family": "Du",
"given": "Yifeng"
}
],
"container-title-short": "Int J Mol Med",
"volume": "58",
"issue": "1",
"page": "178",
"DOI": "10.3892/ijmm.2026.5849",
"PMID": "42138198",
"PMCID": "PMC13170779",
"ISSN": "1107-3756",
"publisher": "Spandidos Publications",
"URL": "https://doi.org/10.3892/ijmm.2026.5849",
"language": "en",
"issued": {
"date-parts": [
[
2026,
5,
15
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.2147/dddt.s627186
Esketamine Attenuates Postoperative Neurocognitive Disorder in Aged Mice: Associations with Bioenergetic Remodeling in Hippocampal CD11b-Enriched Cell Fractions and Glycolysis-Related Signaling.
Journal: Drug design, development and therapy
In common: Alzheimer's / dementia, cellular / molecular, 3 references
[2] doi:10.2147/ijn.s621038
Protein Lactylation in Central Nervous System Diseases: Molecular Mechanisms and Targeted Therapeutic Strategies.
Journal: International journal of nanomedicine
In common: cellular / molecular, 3 references
[3] doi:10.1186/s40478-026-02228-8
microRNA-132 attenuates inflammation in induced pluripotent stem cell-derived microglia from Alzheimer's disease patients.
Journal: Acta neuropathologica communications
In common: Alzheimer's / dementia, cellular / molecular, 3 references
[4] doi:10.1155/humu/2963117
Construction of a Diagnostic Model and Drug Prediction for Postischemic Stroke Cognitive Impairment Based on Machine Learning Screening of Lactate Metabolism- and Pyroptosis-Related Genes.
Journal: Human mutation
In common: Alzheimer's / dementia, 3 references
[5] doi:10.3389/fnagi.2026.1788991
Plasma multi-miRNA models classify Alzheimer's, Parkinson's, and Lewy body dementia.
Journal: Frontiers in aging neuroscience
In common: Alzheimer's / dementia, cellular / molecular, 2 references
[6] doi:10.1007/s10565-026-10177-0
Multi-omics analysis and experimental validation reveal the IRF7-CXCL10 axis as a master regulator of microglial PCD in ischemic stroke.
Journal: Cell biology and toxicology
In common: cellular / molecular, 3 references
[7] doi:10.1038/s41467-026-74037-5
Microglial CD31 suppresses Aβ clearance and promotes Alzheimer pathology in 5×FAD mice.
Journal: Nature communications
In common: Alzheimer's / dementia, cellular / molecular, 2 references
[8] doi:10.1016/j.xcrm.2026.102781
Escherichia coli Nissle 1917 alleviates Alzheimer's disease in mice through OmpA-containing outer membrane vesicles.
Journal: Cell reports. Medicine
In common: Alzheimer's / dementia, cellular / molecular, 2 references
[9] doi:10.1186/s12964-026-02871-7
Hematopoietic cell kinase regulates microglial/macrophage activation to drive neuroinflammation after traumatic brain injury.
Journal: Cell communication and signaling : CCS
In common: cellular / molecular, 2 references
[10] doi:10.1038/s41593-026-02367-0 [code]
A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes.
Journal: Nature neuroscience
In common: Alzheimer's / dementia, cellular / molecular, 2 references

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.