OSCR

Extracellular K<sup>+</sup> modulates the pore conformations of Cys-loop receptor anion channels.

Overview

Authors: Takushi Shimomura1,2,3, Yoshihiro Kubo1,2, Minoru Saitoe4, Yoshinori Suzuki4,5
ORCID iDs: Takushi Shimomura, Yoshihiro Kubo, Minoru Saitoe, Yoshinori Suzuki
  1. Division of Biophysics and Neurobiology, National Institute for Physiological Sciences, Okazaki, Japan
  2. Physiological Sciences Program, Graduate Institute for Advanced Studies (SOKENDAI), Hayama, Japan
  3. Present Address: Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan
  4. Higher Brain Function Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan
  5. Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
Institutions: Hiroshima University (Japan); The Graduate University for Advanced Studies, SOKENDAI (Japan); National Institute for Physiological Sciences (Japan); Tokyo Metropolitan Institute of Medical Science (Japan); Nagoya City University (Japan)
Journal: Nature communications, volume 17, issue 1, article 3453
Dates: received 2 July 2025; accepted 23 March 2026; published online 22 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-71629-z · PMID 42020386 · PMCID PMC13103399 · OpenAlex W7155173365
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), drosophila (organism), cellular / molecular (subfield)
Methods: Statistics, Evoked potentials
Keywords: Ion transport, Ligand-gated ion channels, Molecular modelling
MeSH: Cysteine Loop Ligand-Gated Ion Channel Receptors*, Drosophila Proteins*, Potassium*, Animals, Binding Sites, Drosophila, Drosophila melanogaster, HEK293 Cells, Humans, Phylogeny, Protein Conformation, Receptors, Glycine (* major topic)
Topic: Ion channel regulation and function (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: MEXT | Japan Society for the Promotion of Science (JSPS) (23K27358, 20K07284, 22K15160)
Citations: not cited yet (Europe PMC); 60 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41467-026-71629-z.

Versions

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Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 4 authors, 3 keywords, 12 MeSH terms, 1 funder, 60 references.

Cite

This paper

Shimomura, T., Kubo, Y., Saitoe, M., & Suzuki, Y. (2026). Extracellular K<sup>+</sup> modulates the pore conformations of Cys-loop receptor anion channels. Nature communications, 17(1), 3453. https://doi.org/10.1038/s41467-026-71629-z

BibTeX

@article{shimomura2026extracellular,
author = {Shimomura, Takushi and Kubo, Yoshihiro and Saitoe, Minoru and Suzuki, Yoshinori},
title = {{Extracellular K\<sup\>+\</sup\> modulates the pore conformations of Cys-loop receptor anion channels}},
journal = {Nature communications},
year = {2026},
month = apr,
volume = {17},
number = {1},
pages = {3453},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-71629-z},
url = {https://doi.org/10.1038/s41467-026-71629-z},
pmid = {42020386},
pmcid = {PMC13103399}
}

RIS

TY - JOUR
AU - Shimomura, Takushi
AU - Kubo, Yoshihiro
AU - Saitoe, Minoru
AU - Suzuki, Yoshinori
TI - Extracellular K<sup>+</sup> modulates the pore conformations of Cys-loop receptor anion channels
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/04/22
VL - 17
IS - 1
SP - 3453
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-71629-z
UR - https://doi.org/10.1038/s41467-026-71629-z
LA - en
ER -

CSL-JSON

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"author": [
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"ISSN": "2041-1723",
"publisher": "Nature Publishing Group",
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"language": "en",
"issued": {
"date-parts": [
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}

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