OSCR

Spatial transcriptomic atlas of murine neurotoxocariasis reveals region-specific host responses and dysfunction in the brain.

Overview

Authors: Minyao Zou1, Sishi Liu1, Yi Chen1, Zhiwei Xiong1, Haiyan Wu1, Yi Yang1, Rongqiong Zhou2, Robin B. Gasser3, Guangxu Ma1,3,4
ORCID iDs: Robin B. Gasser, Guangxu Ma
  1. Institute of Preventive Veterinary Medicine, MOA Key Laboratory of Animal Virology, Zhejiang Provincial Engineering Research Center of Animal Biological Products, Zhejiang University Center for Veterinary Sciences, Zhejiang University,Hangzhou, Zhejiang China
  2. College of Veterinary Medicine, Southwest University,Chongqing, China
  3. Faculty of Science, Melbourne Veterinary School, The University of Melbourne,Parkville, VIC Australia
  4. ZJU-Xinchang Joint Innovation Centre (TianMu Laboratory), Gaochuang Hi-Tech Park, Xinchang, China
Institutions: Zhejiang University (China); Southwest University (China); The University of Melbourne (Australia)
Journal: Nature communications, volume 17, issue 1, article 5330
Dates: received 25 May 2025; accepted 8 April 2026; published online 17 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-72114-3 · PMID 41997914 · PMCID PMC13273172 · OpenAlex W7154630926
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), mouse (organism), methods / tools (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Graphs
Keywords: Parasite host response, Parasite immune evasion, Infection
MeSH: Brain*, Host-Parasite Interactions*, Toxocara canis*, Toxocariasis*, Animals, Disease Models, Animal, Female, Larva, Male, Mice, Mice, Inbred C57BL, Neurons, Spatial Transcriptomics, Transcriptome (* major topic)
Topic: Neuroinflammation and Neurodegeneration Mechanisms (Neurology, Neuroscience), according to OpenAlex
Funding: National Natural Science Foundation of China (National Science Foundation of China) (32473050, 32002304); National Basic Research Program of China (2023YFD1801700), the Key Research and Development Program of Zhejiang Province (no. 2023C02036), and Hangzhou Chengxi Sci-tech innovation Corridor Management Committee; RBG’s research program is presently funded by the Australian Research Council and Oz Omics Pty Ltd
Citations: not cited yet (Europe PMC); 70 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

The paper's code and data availability statement is in the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none, so it has no map.

Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41467-026-72114-3.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 3 keywords, 14 MeSH terms, 3 funders, 69 references.

Cite

This paper

Zou, M., Liu, S., Chen, Y., Xiong, Z., Wu, H., Yang, Y., Zhou, R., Gasser, R. B., & Ma, G. (2026). Spatial transcriptomic atlas of murine neurotoxocariasis reveals region-specific host responses and dysfunction in the brain. Nature communications, 17(1), 5330. https://doi.org/10.1038/s41467-026-72114-3

BibTeX

@article{zou2026spatial,
author = {Zou, Minyao and Liu, Sishi and Chen, Yi and Xiong, Zhiwei and Wu, Haiyan and Yang, Yi and Zhou, Rongqiong and Gasser, Robin B. and Ma, Guangxu},
title = {{Spatial transcriptomic atlas of murine neurotoxocariasis reveals region-specific host responses and dysfunction in the brain}},
journal = {Nature communications},
year = {2026},
month = apr,
volume = {17},
number = {1},
pages = {5330},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-72114-3},
url = {https://doi.org/10.1038/s41467-026-72114-3},
pmid = {41997914},
pmcid = {PMC13273172}
}

RIS

TY - JOUR
AU - Zou, Minyao
AU - Liu, Sishi
AU - Chen, Yi
AU - Xiong, Zhiwei
AU - Wu, Haiyan
AU - Yang, Yi
AU - Zhou, Rongqiong
AU - Gasser, Robin B.
AU - Ma, Guangxu
TI - Spatial transcriptomic atlas of murine neurotoxocariasis reveals region-specific host responses and dysfunction in the brain
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/04/17
VL - 17
IS - 1
SP - 5330
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-72114-3
UR - https://doi.org/10.1038/s41467-026-72114-3
LA - en
ER -

CSL-JSON

{
"id": "10.1038/s41467-026-72114-3",
"type": "article-journal",
"title": "Spatial transcriptomic atlas of murine neurotoxocariasis reveals region-specific host responses and dysfunction in the brain",
"container-title": "Nature communications",
"author": [
{
"family": "Zou",
"given": "Minyao"
},
{
"family": "Liu",
"given": "Sishi"
},
{
"family": "Chen",
"given": "Yi"
},
{
"family": "Xiong",
"given": "Zhiwei"
},
{
"family": "Wu",
"given": "Haiyan"
},
{
"family": "Yang",
"given": "Yi"
},
{
"family": "Zhou",
"given": "Rongqiong"
},
{
"family": "Gasser",
"given": "Robin B."
},
{
"family": "Ma",
"given": "Guangxu"
}
],
"container-title-short": "Nat Commun",
"volume": "17",
"issue": "1",
"page": "5330",
"DOI": "10.1038/s41467-026-72114-3",
"PMID": "41997914",
"PMCID": "PMC13273172",
"ISSN": "2041-1723",
"publisher": "Nature Publishing Group",
"URL": "https://doi.org/10.1038/s41467-026-72114-3",
"language": "en",
"issued": {
"date-parts": [
[
2026,
4,
17
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1186/s13073-026-01704-z [code]
Gene expression profiling enables refined parcellation of cortical layers in the heterogeneous human cerebral cortex.
Journal: Genome medicine
In common: genetics / omics, mouse, 4 references
[2] doi:10.1038/s41593-026-02293-1 [code]
Optics-free spatial genomics for mapping mammalian brain aging by IRISeq.
Journal: Nature neuroscience
In common: genetics / omics, mouse, 4 references
[3] doi:10.1038/s41593-026-02387-w [code]
Developing mouse inhibitory neuron single-cell transcriptomes reveal distinct modes of cell-type diversification.
Journal: Nature neuroscience
In common: genetics / omics, mouse, 4 references
[4] doi:10.1093/nargab/lqag039 [code]
SpNeigh: spatial neighborhood and differential expression analysis for high-resolution spatial transcriptomics.
Journal: NAR genomics and bioinformatics
In common: methods / tools, genetics / omics, mouse, 3 references
[5] doi:10.1016/j.isci.2026.117412 [code]
Transcriptomic landscape of microglia in mouse models of social dysfunction and oxytocin-mediated recovery.
Journal: iScience
In common: genetics / omics, mouse, 3 references
[6] doi:10.1101/gr.281113.125 [code]
Single-nucleus multiomic profiling of the aging mouse substantia nigra reveals conserved gene alterations linked to Parkinson's disease.
Journal: Genome research
In common: genetics / omics, mouse, 3 references
[7] doi:10.1016/j.celrep.2026.117073 [code]
Single-cell epigenomics uncovers heterochromatin instability and transcription factor dysfunction during mouse brain aging.
Journal: Cell reports
In common: genetics / omics, mouse, 3 references
[8] doi:10.1016/j.isci.2026.116355 [code]
Tera-MIND: Tera-scale mouse brain simulation via spatial mRNA-guided diffusion.
Journal: iScience
In common: genetics / omics, mouse, 3 references
[9] doi:10.1093/bioinformatics/btag515 [code]
PRISM: Prior-enhanced Inference for Spatial Transcriptomic Cell Type Mapping.
Journal: Bioinformatics (Oxford, England)
In common: genetics / omics, 3 references
[10] doi:10.3390/biomedicines14050998 [code]
Integrative Multi-Omics and Machine Learning Analysis Identifies Therapeutic Targets and Drug Repurposing Candidates for Alzheimer's Disease.
Journal: Biomedicines
In common: genetics / omics, 3 references

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.