OSCR

Complex I protein NDUFB9 is a metabolic vulnerability in triple negative breast cancer brain metastases.

Overview

Authors: Mingxi Lin1,2, Zhexu Wen3, Cheng Zeng1,2, Yizi Jin1,2, Teng Zhou1,2, Yuxin Yan1,2, Shenglin Huang2,4,5, Xin Hu2,6, Xiaoxiang Guan7,8, Xichun Hu1,2, Jian Zhang1,2,9
ORCID iDs: Shenglin Huang, Xin Hu, Xiaoxiang Guan, Xichun Hu, Jian Zhang
  1. Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
  2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
  3. Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  4. Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
  5. Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China
  6. Precision Cancer Medical Center Affiliated to Fudan University Shanghai Cancer Center, Shanghai, China
  7. Department of Oncology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China
  8. Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China
  9. Phase I Clinical Trial Center, Fudan University Shanghai Cancer Center, Shanghai, China
Institutions: Shanghai Medical College of Fudan University (China); Fudan University (China); Fudan University Shanghai Cancer Center (China); Shanghai Jiao Tong University (China); Shanghai Chest Hospital (China); Jiangsu Province Hospital (China); Nanjing Medical University (China)
Journal: Nature communications, volume 17, issue 1, article 6262
Dates: received 3 October 2025; accepted 23 April 2026; published online 9 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-72927-2 · PMID 42103753 · PMCID PMC13376752 · OpenAlex W7160661557
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), other condition (population), cellular / molecular (subfield)
Methods: Preprocessing, Statistics, Evoked potentials
Keywords: Breast cancer, Metastasis, Cancer metabolism
MeSH: Brain Neoplasms*, Electron Transport Complex I*, NADH Dehydrogenase*, Triple Negative Breast Neoplasms*, Animals, Asparagine, Aspartate-Ammonia Ligase, Aspartic Acid, Cell Line, Tumor, Cell Proliferation, Female, Humans, Mice, Mitochondria, Tumor Microenvironment (* major topic)
Topic: Cancer, Hypoxia, and Metabolism (Cancer Research, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Natural Science Foundation of China (National Science Foundation of China) (82072915, 82373359, 82473071, 82503430)
Citations: not cited yet (Europe PMC); 73 references in the paper
Research resources: anti-beta Actin RRID:AB_10700003, anti-ASNS RRID:AB_2060119, anti-SHMT2 RRID:AB_2188452, anti-phospho-T389 S6K RRID:AB_2269803, anti-ATF4 RRID:AB_2616025, anti-UQCRC2 RRID:AB_2797139, anti-ATP5A1 RRID:AB_2801536, anti-NDUFB8 RRID:AB_2847808, anti-MTCO2 RRID:AB_2861364, anti-SDHB RRID:AB_2904585, anti-NDUFB9 RRID:AB_3668935, anti-S6K RRID:AB_390722

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Code and data availability statement

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Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 3 keywords, 15 MeSH terms, 1 funder, 73 references, 12 RRIDs.

Cite

This paper

Lin, M., Wen, Z., Zeng, C., Jin, Y., Zhou, T., Yan, Y., Huang, S., Hu, X., Guan, X., Hu, X., & Zhang, J. (2026). Complex I protein NDUFB9 is a metabolic vulnerability in triple negative breast cancer brain metastases. Nature communications, 17(1), 6262. https://doi.org/10.1038/s41467-026-72927-2

BibTeX

@article{lin2026complex,
author = {Lin, Mingxi and Wen, Zhexu and Zeng, Cheng and Jin, Yizi and Zhou, Teng and Yan, Yuxin and Huang, Shenglin and Hu, Xin and Guan, Xiaoxiang and Hu, Xichun and Zhang, Jian},
title = {{Complex I protein NDUFB9 is a metabolic vulnerability in triple negative breast cancer brain metastases}},
journal = {Nature communications},
year = {2026},
month = may,
volume = {17},
number = {1},
pages = {6262},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-72927-2},
url = {https://doi.org/10.1038/s41467-026-72927-2},
pmid = {42103753},
pmcid = {PMC13376752}
}

RIS

TY - JOUR
AU - Lin, Mingxi
AU - Wen, Zhexu
AU - Zeng, Cheng
AU - Jin, Yizi
AU - Zhou, Teng
AU - Yan, Yuxin
AU - Huang, Shenglin
AU - Hu, Xin
AU - Guan, Xiaoxiang
AU - Hu, Xichun
AU - Zhang, Jian
TI - Complex I protein NDUFB9 is a metabolic vulnerability in triple negative breast cancer brain metastases
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/05/09
VL - 17
IS - 1
SP - 6262
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-72927-2
UR - https://doi.org/10.1038/s41467-026-72927-2
LA - en
ER -

CSL-JSON

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