OSCR

Single-cell and spatial transcriptomes reveal oligodendrocyte remodeling fatty acid metabolism microenvironment of lung cancer brain metastases.

Overview

Authors: Yuechao Yang1,2, Yang Gao1,2, Zhe Qi1,2, Sen Li1,2, Zhisu Wang1,2, Deheng Li1,2, Lei Chen1,2, Changshuai Zhou1,2, Mingtao Feng1,2, Xin Chen1,2, Bin Hao1,2, Xiaojun Wu1,2, Liangdong Li1,2, Yiqun Cao1,2
  1. Department of Neurosurgery, Fudan University Shanghai Cancer Center, Shanghai, 200032 China
  2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032 China
Institutions: Shanghai Medical College of Fudan University (China); Fudan University (China); Fudan University Shanghai Cancer Center (China)
Journal: Journal of translational medicine, volume 24, issue 1, article 1099
Dates: received 6 October 2025; accepted 7 June 2026; published online 16 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12967-026-08447-w · PMID 42304367 · PMCID PMC13520405 · OpenAlex W7164922944
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), human (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Evoked potentials, Machine learning
Keywords: Oligodendrocytes, Tumor microenvironment, Fatty acid metabolism, Macrophage
MeSH: Brain Neoplasms*, Fatty Acids*, Lung Neoplasms*, Oligodendroglia*, Single-Cell Analysis*, Tumor Microenvironment*, Animals, Cell Line, Tumor, Cell Proliferation, Gene Expression Regulation, Neoplastic, Humans, Lipid Metabolism, Macrophages, Metabolic Reprogramming, Spatial Transcriptomics (* major topic)
Topic: Glioma Diagnosis and Treatment (Genetics, Medicine), according to OpenAlex
Funding: National Natural Science Foundation of China (No. 8247295)
Citations: not cited yet (Europe PMC); 52 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none, so it has no map.

Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1186/s12967-026-08447-w.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 14 authors, 4 keywords, 15 MeSH terms, 1 funder, 52 references.

Cite

This paper

Yang, Y., Gao, Y., Qi, Z., Li, S., Wang, Z., Li, D., Chen, L., Zhou, C., Feng, M., Chen, X., Hao, B., Wu, X., Li, L., & Cao, Y. (2026). Single-cell and spatial transcriptomes reveal oligodendrocyte remodeling fatty acid metabolism microenvironment of lung cancer brain metastases. Journal of translational medicine, 24(1), 1099. https://doi.org/10.1186/s12967-026-08447-w

BibTeX

@article{yang2026single,
author = {Yang, Yuechao and Gao, Yang and Qi, Zhe and Li, Sen and Wang, Zhisu and Li, Deheng and Chen, Lei and Zhou, Changshuai and Feng, Mingtao and Chen, Xin and Hao, Bin and Wu, Xiaojun and Li, Liangdong and Cao, Yiqun},
title = {{Single-cell and spatial transcriptomes reveal oligodendrocyte remodeling fatty acid metabolism microenvironment of lung cancer brain metastases}},
journal = {Journal of translational medicine},
year = {2026},
month = jun,
volume = {24},
number = {1},
pages = {1099},
publisher = {BMC},
issn = {1479-5876},
doi = {10.1186/s12967-026-08447-w},
url = {https://doi.org/10.1186/s12967-026-08447-w},
pmid = {42304367},
pmcid = {PMC13520405}
}

RIS

TY - JOUR
AU - Yang, Yuechao
AU - Gao, Yang
AU - Qi, Zhe
AU - Li, Sen
AU - Wang, Zhisu
AU - Li, Deheng
AU - Chen, Lei
AU - Zhou, Changshuai
AU - Feng, Mingtao
AU - Chen, Xin
AU - Hao, Bin
AU - Wu, Xiaojun
AU - Li, Liangdong
AU - Cao, Yiqun
TI - Single-cell and spatial transcriptomes reveal oligodendrocyte remodeling fatty acid metabolism microenvironment of lung cancer brain metastases
T2 - Journal of translational medicine
J2 - J Transl Med
PY - 2026
DA - 2026/06/16
VL - 24
IS - 1
SP - 1099
SN - 1479-5876
PB - BMC
DO - 10.1186/s12967-026-08447-w
UR - https://doi.org/10.1186/s12967-026-08447-w
LA - en
ER -

CSL-JSON

{
"id": "10.1186/s12967-026-08447-w",
"type": "article-journal",
"title": "Single-cell and spatial transcriptomes reveal oligodendrocyte remodeling fatty acid metabolism microenvironment of lung cancer brain metastases",
"container-title": "Journal of translational medicine",
"author": [
{
"family": "Yang",
"given": "Yuechao"
},
{
"family": "Gao",
"given": "Yang"
},
{
"family": "Qi",
"given": "Zhe"
},
{
"family": "Li",
"given": "Sen"
},
{
"family": "Wang",
"given": "Zhisu"
},
{
"family": "Li",
"given": "Deheng"
},
{
"family": "Chen",
"given": "Lei"
},
{
"family": "Zhou",
"given": "Changshuai"
},
{
"family": "Feng",
"given": "Mingtao"
},
{
"family": "Chen",
"given": "Xin"
},
{
"family": "Hao",
"given": "Bin"
},
{
"family": "Wu",
"given": "Xiaojun"
},
{
"family": "Li",
"given": "Liangdong"
},
{
"family": "Cao",
"given": "Yiqun"
}
],
"container-title-short": "J Transl Med",
"volume": "24",
"issue": "1",
"page": "1099",
"DOI": "10.1186/s12967-026-08447-w",
"PMID": "42304367",
"PMCID": "PMC13520405",
"ISSN": "1479-5876",
"publisher": "BMC",
"URL": "https://doi.org/10.1186/s12967-026-08447-w",
"language": "en",
"issued": {
"date-parts": [
[
2026,
6,
16
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1038/s41467-026-70715-6
Identification of altered immune landscape at single-cell resolution in NSCLC brain metastasis and its association with poor immune checkpoint inhibitor responses.
Journal: Nature communications
In common: NCBI GEO GSE131907, other condition, cellular / molecular, 5 references
[2] doi:10.1038/s41467-026-72927-2
Complex I protein NDUFB9 is a metabolic vulnerability in triple negative breast cancer brain metastases.
Journal: Nature communications
In common: other condition, cellular / molecular, 5 references
[3] doi:10.21037/tcr-2026-1-0228
Phagocytic remodeling in CD74<sup>High</sup> tumor-associated macrophages during brain metastasis of lung adenocarcinoma.
Journal: Translational cancer research
In common: NCBI GEO GSE131907, other condition, 2 references
[4] doi:10.1007/s12672-026-05341-1
Single-cell data analysis of lung cancer brain metastasis reveals SEC61G serves as a potential risk indicator.
Journal: Discover oncology
In common: NCBI GEO GSE131907, genetics / omics, other condition, cellular / molecular, 1 reference
[5] doi:10.1038/s41419-026-08807-w [code]
Single-cell profiling reveals distinct populations of tumor-associated macrophages and metastatic tumor cells in breast cancer brain metastasis.
Journal: Cell death & disease
In common: genetics / omics, other condition, cellular / molecular, 4 references
[6] doi:10.1038/s42003-026-10382-x [code]
ScQCenrich enables multi-metric quality control for single-cell RNA sequencing.
Journal: Communications biology
In common: NCBI GEO GSE131907, genetics / omics, cellular / molecular, 1 reference
[7] doi:10.7554/elife.106347 [code]
Esr1-dependent signaling and transcriptional maturation in the medial preoptic area of the hypothalamus shape the development of mating behavior during adolescence.
Journal: eLife
In common: genetics / omics, 5 references
[8] doi:10.3389/fcell.2026.1738641
Integrative single-cell and bulk RNA sequencing unravels the role of ACTN1 in promoting lung cancer with brain metastasis and epidermal growth factor receptor-tyrosine kinase inhibitor resistance.
Journal: Frontiers in cell and developmental biology
In common: genetics / omics, other condition, cellular / molecular, 3 references
[9] doi:10.1016/j.isci.2026.116517 [code]
Spatially resolved transcriptomics in human brain metastases identifies macrophage-tumor interactions associated with survival.
Journal: iScience
In common: genetics / omics, other condition, 3 references
[10] doi:10.1038/s42003-026-09915-1
Single cell and spatial sequencing analysis of cancer associated fibroblasts in the brain metastasis tumor microenvironment.
Journal: Communications biology
In common: genetics / omics, other condition, cellular / molecular, 3 references

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.