Brain FGF2 and NCAM1 contribute to FGFR1-dependent progression of estrogen receptor-positive breast cancer brain metastases.
Overview
- Department of Pathology, University of Colorado Anschutz,Aurora, CO USA
- Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz,Aurora, CO USA
- University of Colorado Comprehensive Cancer Center, University of Colorado Anschutz,Aurora, CO USA
- Department of Radiology, University of Colorado Anschutz,Aurora, CO USA
- Department of Pathology, University of Oklahoma Health Sciences Center,Oklahoma City, OK USA
- Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center,Oklahoma City, OK USA
- Stephenson Cancer Center, University of Oklahoma Health Sciences Center,Oklahoma City, OK USA
Abstract
Estrogen receptor-positive breast cancer represents a significant proportion of breast cancer brain metastasis but remains understudied. Here we show that FGFR1-amplification, a well-established driver of estrogen receptor-positive breast cancer endocrine resistance, promotes estrogen receptor-positive breast cancer brain metastatic colonization in young and aged female mice, through both canonical FGF2/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
The paper links to its data, not to its authors' code: see the Data section.
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All information is provided in the Methods, including packages, software, and pipelines. No custom code was generated during these studies.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- geo:GSE301400, at NCBI GEO; found in “Data availability”
Data availability
The Digital Spatial Profiling and RNA-sequencing data generated in this study have been deposited in the NCBI’s Gene Expression Omnibus under accession codes GSE301400 (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 13 authors, 3 keywords, 18 MeSH terms, 2 funders, 80 references, 3 RRIDs.
Cite
This paper
Fox, M. S., Jaramillo-Gómez, J. A., Marquez-Ortiz, R. A., Alvarez-Eraso, K. L. F., Contreras-Zárate, M. J., Pham, T. C., Barela, E. N., Koliavas, S. N., Kabos, P., Serkova, N. J., Sartorius, C. A., Wellberg, E. A., & Cittelly, D. M. (2026). Brain FGF2 and NCAM1 contribute to FGFR1-dependent progression of estrogen receptor-positive breast cancer brain metastases. Nature communications, 17(1), 6945. https://
BibTeX
@article{fox2026brain,
author = {Fox, Morgan S. and Jaramillo-Gómez, Jenny A. and Marquez-Ortiz, R. Alejandro and Alvarez-Eraso, Karen L. F. and Contreras-Zárate, Maria J. and Pham, Trinh C. and Barela, Elaina N. and Koliavas, Stella N. and Kabos, Peter and Serkova, Natalie J. and Sartorius, Carol A. and Wellberg, Elizabeth A. and Cittelly, Diana M.},
title = {{Brain FGF2 and NCAM1 contribute to FGFR1-dependent progression of estrogen receptor-positive breast cancer brain metastases}},
journal = {Nature communications},
year = {2026},
month = may,
volume = {17},
number = {1},
pages = {6945},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/
url = {https://
pmid = {42209519},
pmcid = {PMC13388965}
}
RIS
TY - JOUR
AU - Fox, Morgan S.
AU - Jaramillo-Gómez, Jenny A.
AU - Marquez-Ortiz, R. Alejandro
AU - Alvarez-Eraso, Karen L. F.
AU - Contreras-Zárate, Maria J.
AU - Pham, Trinh C.
AU - Barela, Elaina N.
AU - Koliavas, Stella N.
AU - Kabos, Peter
AU - Serkova, Natalie J.
AU - Sartorius, Carol A.
AU - Wellberg, Elizabeth A.
AU - Cittelly, Diana M.
TI - Brain FGF2 and NCAM1 contribute to FGFR1-dependent progression of estrogen receptor-positive breast cancer brain metastases
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/
VL - 17
IS - 1
SP - 6945
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.1038/
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"container-title": "Nature communications",
"author": [
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