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IQGAP3 bridges matrix stiffness with glioma stem cell maintenance and radioresistance by stabilizing SOX2.

Overview

Authors: Po Zhang1,2, Weichi Wu1,2,3, Tengfei Huang1,2,3, Xujia Wu1,2, Donghai Wang1,2,3, Huairui Yuan1,2, Suchet Taori1,2, Fanen Yuan1,2, Frank P Vendetti4, Rui Wang1,2,3, Tingting Duan1,2, Hailong Mi1,2, Huan Li1,2,3, Kailin Yang5, Daqi Li1,2,3, Ahmed Habib1,6, Briana C Prager7, Ryan C Gimple8, Pascal O Zinn1,6, Kalil Abdullah1,6, Christopher Bakkenist1,4, Junran Zhang9, Qiulian Wu1,2,3, Jeremy N Rich1,3,10,11
ORCID iDs: Xujia Wu, Tingting Duan, Daqi Li, Ryan C Gimple, Junran Zhang, Jeremy N Rich
  1. UPMC Hillman Cancer Center, Pittsburgh, PA USA
  2. Department of Medicine, University of Pittsburgh, Pittsburgh, PA USA
  3. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC USA
  4. Department of Radiation Oncology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA USA
  5. Department of Radiation Oncology, Holden Comprehensive Cancer Center, University of Iowa, Iowa, IA USA
  6. Department of Neurosurgery, University of Pittsburgh, Pittsburgh, PA USA
  7. Department of Neurosurgery, Massachusetts General Hospital, Boston, MA USA
  8. Department of Medical Oncology, Washington University in Saint Louis, Saint Louis, MO USA
  9. Department of Radiation Oncology, The Ohio State University Comprehensive Cancer Center and College of Medicine, Columbus, OH USA
  10. Department of Neurology, University of Pittsburgh, Pittsburgh, PA USA
  11. Depssartment of Neurology, University of North Carolina, Chapel Hill, NC USA
Institutions: University of Pittsburgh (United States); UPMC Hillman Cancer Center (United States); University of North Carolina at Chapel Hill (United States); UNC Lineberger Comprehensive Cancer Center; University of Pittsburgh Medical Center (United States); University of Iowa (United States); University of Iowa Holden Comprehensive Cancer Center; Massachusetts General Hospital (United States); Washington University in St. Louis (United States); The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (United States); The Ohio State University (United States)
Journal: Nature communications, volume 17, issue 1, article 7231
Dates: received 21 February 2025; accepted 22 May 2026; published online 6 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-74058-0 · PMID 42251046 · PMCID PMC13396378 · OpenAlex W7163760516
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning
Keywords: CNS cancer, Cancer stem cells, Cancer microenvironment
MeSH: Brain Neoplasms*, Glioblastoma*, Glioma*, Neoplastic Stem Cells*, Radiation Tolerance*, SOXB1 Transcription Factors*, Adaptor Proteins, Signal Transducing, Animals, Cell Line, Tumor, Extracellular Matrix, Gene Expression Regulation, Neoplastic, Humans, Mice, Transcription Factors, Tumor Microenvironment, YAP-Signaling Proteins (* major topic)
Topic: Hippo pathway signaling and YAP/TAZ (Cell Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Foundation for the National Institutes of Health (CA238662, CA283998, NS136424, NS134724, NS103434, CA268634); NCI NIH HHS (R01 CA238662, R01 CA268634, R35 CA283998); NINDS NIH HHS (R01 NS103434, R01 NS134724, R01 NS136424); United States Department of Defense | Defense Health Agency (HT9425-23-1-0689)
Citations: not cited yet (Europe PMC); 75 references in the paper

Abstract

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Code

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Code availability statement

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  • no repository, dataset or request procedure was recognized in it

Read it in the paper: doi.org/10.1038/s41467-026-74058-0.

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Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it points to a dataset: NCBI GEO GSE59612
  • it says that the data are available on request

Read it in the paper: doi.org/10.1038/s41467-026-74058-0.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 24 authors, 3 keywords, 16 MeSH terms, 4 funders, 75 references.

Cite

This paper

Zhang, P., Wu, W., Huang, T., Wu, X., Wang, D., Yuan, H., Taori, S., Yuan, F., Vendetti, F. P., Wang, R., Duan, T., Mi, H., Li, H., Yang, K., Li, D., Habib, A., Prager, B. C., Gimple, R. C., Zinn, P. O., . . . Rich, J. N. (2026). IQGAP3 bridges matrix stiffness with glioma stem cell maintenance and radioresistance by stabilizing SOX2. Nature communications, 17(1), 7231. https://doi.org/10.1038/s41467-026-74058-0

BibTeX

@article{zhang2026iqgap3,
author = {Zhang, Po and Wu, Weichi and Huang, Tengfei and Wu, Xujia and Wang, Donghai and Yuan, Huairui and Taori, Suchet and Yuan, Fanen and Vendetti, Frank P and Wang, Rui and Duan, Tingting and Mi, Hailong and Li, Huan and Yang, Kailin and Li, Daqi and Habib, Ahmed and Prager, Briana C and Gimple, Ryan C and Zinn, Pascal O and Abdullah, Kalil and Bakkenist, Christopher and Zhang, Junran and Wu, Qiulian and Rich, Jeremy N},
title = {{IQGAP3 bridges matrix stiffness with glioma stem cell maintenance and radioresistance by stabilizing SOX2}},
journal = {Nature communications},
year = {2026},
month = jun,
volume = {17},
number = {1},
pages = {7231},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-74058-0},
url = {https://doi.org/10.1038/s41467-026-74058-0},
pmid = {42251046},
pmcid = {PMC13396378}
}

RIS

TY - JOUR
AU - Zhang, Po
AU - Wu, Weichi
AU - Huang, Tengfei
AU - Wu, Xujia
AU - Wang, Donghai
AU - Yuan, Huairui
AU - Taori, Suchet
AU - Yuan, Fanen
AU - Vendetti, Frank P
AU - Wang, Rui
AU - Duan, Tingting
AU - Mi, Hailong
AU - Li, Huan
AU - Yang, Kailin
AU - Li, Daqi
AU - Habib, Ahmed
AU - Prager, Briana C
AU - Gimple, Ryan C
AU - Zinn, Pascal O
AU - Abdullah, Kalil
AU - Bakkenist, Christopher
AU - Zhang, Junran
AU - Wu, Qiulian
AU - Rich, Jeremy N
TI - IQGAP3 bridges matrix stiffness with glioma stem cell maintenance and radioresistance by stabilizing SOX2
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/06/06
VL - 17
IS - 1
SP - 7231
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-74058-0
UR - https://doi.org/10.1038/s41467-026-74058-0
LA - en
ER -

CSL-JSON

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