Calpain-mediated TBP cleavage disturbs neuronal AMOT-YAP1 signalling.
Overview
- Department of Human Genetics, Medical Faculty, Ruhr University Bochum,Bochum, Germany
- Institute of Medical Genetics and Applied Genomics, University of Tübingen,Tübingen, Germany
- Department of Neurology, Huntington Center NRW, St. Josef-Hospital Bochum, Ruhr University Bochum,Bochum, Germany
- Department of Experimental and Clinical Pharmacology and Pharmacogenomics, Section of Pharmacogenomics, University of Tübingen,Tübingen, Germany
- German Center for Neurodegenerative Diseases (DZNE),Tübingen, Germany
- Hertie Institute for Clinical Brain Research, University of Tübingen,Tübingen, Germany
- NGS Competence Center Tübingen, University of Tübingen,Tübingen, Germany
- Proteome Center Tübingen, University of Tübingen,Tübingen, Germany
Abstract
The transcription factor TATA-box-binding protein (TBP) plays a crucial role in neurons, as highlighted by its involvement in spinocerebellar ataxia type 17 (SCA17), where pathological polyglutamine expansions disrupt its function. While the molecular pathomechanisms remain unclear, our previous study showed that calcium-activated calpains cleave TBP in SCA17 cell and animal models. Here, we pinpoint a major calpain cleavage site after residue T106, C-terminal to TBP’s polyglutamine tract. The resulting polyglutamine-containing
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
No file of the authors' code could be read here: it is described below, and read at its source.
Zenodo 22231266
Availability: 1 check, the latest on 12 November 2026: the link answers (HTTP 200)
- 12 November 2026: the link answers (HTTP 200)
Code availability
Standard codes and software tools, as listed in the “Methods” section, were used in this study. Custom Fiji macros developed for the analysis of microscopy images are provided as Supplementary Software and have been deposited at Zenodo (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- geo:GSE346419, at NCBI GEO; found in “Data availability”
- pride:PXD083710, at PRIDE; found in “Data availability”
Data availability
All data required to support the findings of this study are available within the article, the supplementary information, or are available in publicly available data repositories. The RNA sequencing data generated in this study have been deposited in the NCBI Gene Expression Omnibus (GEO) database under accession code GSE346419 (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 12 November 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 16 authors, 5 keywords, 16 MeSH terms, 2 funders, 99 references, 2 RRIDs.
Cite
This paper
Incebacak Eltemur, R. D., Fath, F., Huridou, C., Phu, M. D., Stoltenow, T. I., Helm, J., Pereira Sena, P., Casadei, N., Velic, A., Perera, R. P., Macek, B., Riess, O., Hauser, S., Nguyen, H. P., Philipp, M., & Weber, J. J. (2026). Calpain-mediated TBP cleavage disturbs neuronal AMOT-YAP1 signalling. Nature communications, 17(1), 11531. https://
BibTeX
@article{incebacakeltemu
author = {Incebacak Eltemur, Rana Dilara and Fath, Florian and Huridou, Chrisovalantou and Phu, Max Duong and Stoltenow, Till Ivo and Helm, Jacob and Pereira Sena, Priscila and Casadei, Nicolas and Velic, Ana and Perera, Roshan Priyarangana and Macek, Boris and Riess, Olaf and Hauser, Stefan and Nguyen, Huu Phuc and Philipp, Melanie and Weber, Jonasz Jeremiasz},
title = {{Calpain-mediated TBP cleavage disturbs neuronal AMOT-YAP1 signalling}},
journal = {Nature communications},
year = {2026},
month = nov,
volume = {17},
number = {1},
pages = {11531},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/
url = {https://
pmid = {43003872},
pmcid = {PMC13748621}
}
RIS
TY - JOUR
AU - Incebacak Eltemur, Rana Dilara
AU - Fath, Florian
AU - Huridou, Chrisovalantou
AU - Phu, Max Duong
AU - Stoltenow, Till Ivo
AU - Helm, Jacob
AU - Pereira Sena, Priscila
AU - Casadei, Nicolas
AU - Velic, Ana
AU - Perera, Roshan Priyarangana
AU - Macek, Boris
AU - Riess, Olaf
AU - Hauser, Stefan
AU - Nguyen, Huu Phuc
AU - Philipp, Melanie
AU - Weber, Jonasz Jeremiasz
TI - Calpain-mediated TBP cleavage disturbs neuronal AMOT-YAP1 signalling
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/
VL - 17
IS - 1
SP - 11531
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/
UR - https://
LA - en
ER -
CSL-JSON
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