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Inconsistent subthalamic local field potential beta activity amid in- and antiphasic neuronal bursts.

Code ↔ Paper

3 matches between paragraphs of the paper and lines of its authors' code, computed by the harvester (lexical-v1). Click a colored paragraph or line to see its counterpart.

The 3 matches
  1. [1] § Methods › Beta peak detection ↔ feat_ex/beta/core.py, lines 1–51 · score 0.83 · 15–36 Hz, 10–36, 5–45, 6–14, 1–6, bin
  2. [2] § Results › Bilateral prevalence of STN-LFP beta power is 47.25% per patient ↔ eval/beta_prev_stats.py, lines 798–824 · score 0.74 · Unilateral prevalence, hemisphere prevalence, Bilateral prevalence, Beta peaks, LFP beta, artifact
  3. [3] § Methods › Anatomical reconstruction of microelectrode positions ↔ feat_ex/spatial/volumetric_screen.py, lines 229–246 · score 0.60 · MNI space, DBS lead, microelectrode, shift, trajectories, position

Paper

Loaded from Europe PMC by your browser, not stored by OSCR: doi.org · Europe PMC

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The authors' code

Python · 1,058 lines · 52 KB · no license · 1 match

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It can be read at the source: feat_ex/beta/core.py.

Overview

Authors: Maximilian Scherer1, Nina Wiedemann1, Kai Bötzel1, Matthias Löhle2,3, Thomas Kriesen4, Daniel Cantré5, Jan Hinnerk Mehrkens6, René Reese2, Thomas Koeglsperger1,7
  1. Department of Neurology, LMU University Hospital, LMU Munich, Munich, Germany
  2. Department of Neurology, Rostock University Medical Center, Rostock, Germany
  3. German Center for Neurodegenerative Diseases (DZNE) Rostock/Greifswald, Rostock, Germany
  4. Department of Neurosurgery, Rostock University Medical Center, Rostock, Germany
  5. Institute and Policlinic of Radiology, Pediatric Radiology and Neuroradiology, Rostock University Medical Center, Rostock, Germany
  6. Department of Neurosurgery, LMU University Hospital, LMU Munich, Munich, Germany
  7. Department of Translational Brain Research, German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
Institutions: LMU Klinikum (Germany); Ludwig-Maximilians-Universität München (Germany); German Center for Neurodegenerative Diseases (Germany); Universitätsmedizin Rostock (Germany)
Journal: NPJ Parkinson's disease, volume 12, issue 1, article 222
Dates: received 12 February 2026; accepted 8 August 2026; published online 16 September 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1038/s41531-026-01531-4 · PMID 42749741 · PMCID PMC13582961 · OpenAlex W7213334037
Open access: gold, a free copy (OpenAlex)
Status: code verified
Categories: extracellular electrophysiology (units, LFP) (modality), human (organism), Parkinson's (population), clinical / translational (subfield)
Methods: Spectral & time-frequency, Connectivity, Preprocessing, Smoothing, state filtering, decompositions
Keywords: Biomarkers, Neurology, Neuroscience
Topic: Neurological disorders and treatments (Neurology, Medicine), according to OpenAlex
Funding: Alexander von Humboldt-Stiftung
Citations: not cited yet (Europe PMC); 60 references in the paper

Abstract

Elevated subthalamic (STN) beta (12–32 Hz) local field potentials (LFP) are a hallmark of Parkinson’s disease and closely tied to synchronized spiking. The biomarker guides deep brain stimulation (DBS) lead implantation and is under investigation to inform DBS programming and adaptive DBS, yet its prevalence has not been independently assessed. This study assesses the biomarkers prevalence and investigating its relationship to synchronized beta-bursting neurons. STN LFPs and spiking activity of n = 156 patients with Parkinson’s disease from seven DBS centers recorded via microelectrodes were examined and spectral LFP peaks classified. The distribution of phase angles between beta LFP and beta-bursting neurons was explored. Beta LFPs were bilaterally expressed in 47.25% of patients (65.59% of hemispheres). LFP-synchronized neuronal spiking clustered in two peaks, 182.84° phase shifted. This applied on the group level and for individual patients. Beta-LFP-informed approaches mandate reliable biomarker expression, a requirement not met by 52.75% of patients. This is particularly troublesome for intraoperative guidance wherein the cause of biomarker absence, including DBS lead misplacement or a balanced ratio of phasic and antiphasic spiking neurons, cannot be determined. While STN-LFP beta remains a valuable biomarker, multiple biomarkers should be evaluated simultaneously to increase robustness.

Reproduced under the paper's license (CC BY), from the paper cited above.

Repositories

Its files are read in the Code ↔ Paper reader above, with 3 matches between paragraphs and lines of code.

MaximilianScherer/2026_MS_beta_prevalence

License: none: the authors keep all their rights
State: the link answers, verified on 26 September 2026
Evidence: files inventoried
Commit: 7c9f1e9088ffed9e8d845ccf5034c349fa39cb4f, 15 December 2025
Languages: Python (34), MATLAB (2)
Size: 40 files, 36 scripts
Software Heritage: not archived
Found in: “Code availability”
Holds: environment (pyproject.toml)
Not found: README, license file, CITATION.cff, tests, continuous integration, documentation
Tools: NumPy (22 files), SciPy (13 files), Matplotlib (8 files), pandas (3 files), h5py (2 files), LMFIT (1 file), MNE-Python (1 file), Neo (1 file), NiBabel (1 file), scikit-image (1 file), scikit-learn (1 file)
Availability: 1 check, the latest on 26 September 2026: the link answers
  • 26 September 2026: the link answers
36 files, not copied: shown from their source

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At the source: codeberg.org/MaximilianScherer/2026_MS_beta_prevalence.git

Zenodo 17951551

License: CC-BY-4.0
State: the link answers, verified on 26 September 2026
Evidence: files inventoried
Size: 2 files
Software Heritage: not checked
Found in: the references
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 26 September 2026: the link answers (HTTP 200)
  • 26 September 2026: the link answers (HTTP 200)
At the source:

Zenodo 17940236

License: CC-BY-4.0
State: the link answers, verified on 26 September 2026
Evidence: files inventoried
Size: 1 file
Software Heritage: not checked
Found in: the references
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Tools: NumPy (22 files), SciPy (13 files), Matplotlib (8 files), pandas (3 files), h5py (2 files), LMFIT (1 file), MNE-Python (1 file), Neo (1 file), NiBabel (1 file), scikit-image (1 file), scikit-learn (1 file)
Availability: 1 check, the latest on 26 September 2026: the link answers (HTTP 200)
  • 26 September 2026: the link answers (HTTP 200)
36 files
At the source:

Code availability

Python code written to support this evaluation has been made available at: https://codeberg.org/MaximilianScherer/2026_MS_beta_prevalence.git60.

Reproduced under the paper's license (CC BY), from the paper cited above.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 3 repositories of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 72 scripts, each with its path and the digest of its content;
  • 3 matches between paragraphs of the paper and lines of the code (method lexical-v1);
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

Datasets cited

Data availability

Data from cohorts 1 to 3 are publicly available33,46,51. Data from cohorts 4 & 5 may be shared upon request. Graphical documentations for all LFP/spike evaluations individually, as well as microelectrode reconstructions, are available at zenodo59.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 3, 28 September 2026

  • Funding: added Alexander von Humboldt-Stiftung

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 3 keywords, 57 references.

Cite

This paper

Scherer, M., Wiedemann, N., Bötzel, K., Löhle, M., Kriesen, T., Cantré, D., Mehrkens, J. H., Reese, R., & Koeglsperger, T. (2026). Inconsistent subthalamic local field potential beta activity amid in- and antiphasic neuronal bursts. NPJ Parkinson's disease, 12(1), 222. https://doi.org/10.1038/s41531-026-01531-4

BibTeX

@article{scherer2026inconsistent,
author = {Scherer, Maximilian and Wiedemann, Nina and Bötzel, Kai and Löhle, Matthias and Kriesen, Thomas and Cantré, Daniel and Mehrkens, Jan Hinnerk and Reese, René and Koeglsperger, Thomas},
title = {{Inconsistent subthalamic local field potential beta activity amid in- and antiphasic neuronal bursts}},
journal = {NPJ Parkinson's disease},
year = {2026},
month = sep,
volume = {12},
number = {1},
pages = {222},
publisher = {Nature Publishing Group},
issn = {2373-8057},
doi = {10.1038/s41531-026-01531-4},
url = {https://doi.org/10.1038/s41531-026-01531-4},
pmid = {42749741},
pmcid = {PMC13582961}
}

RIS

TY - JOUR
AU - Scherer, Maximilian
AU - Wiedemann, Nina
AU - Bötzel, Kai
AU - Löhle, Matthias
AU - Kriesen, Thomas
AU - Cantré, Daniel
AU - Mehrkens, Jan Hinnerk
AU - Reese, René
AU - Koeglsperger, Thomas
TI - Inconsistent subthalamic local field potential beta activity amid in- and antiphasic neuronal bursts
T2 - NPJ Parkinson's disease
J2 - NPJ Parkinsons Dis
PY - 2026
DA - 2026/09/16
VL - 12
IS - 1
SP - 222
SN - 2373-8057
PB - Nature Publishing Group
DO - 10.1038/s41531-026-01531-4
UR - https://doi.org/10.1038/s41531-026-01531-4
LA - en
ER -

CSL-JSON

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