OSCR

BTK promotes neuroinflammation after intracerebral hemorrhage involving hub genes and alterations in microglial functions.

Overview

Authors: Siqi Xia1,2, Gao Chen1,2
  1. Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, Hangzhou, 310016 Zhejiang China
  2. Key Laboratory of Precise Treatment and Clinical Translational Research of Neurological Diseases, Hangzhou, 310016 Zhejiang China
Institutions: Second Affiliated Hospital of Zhejiang University (China); Zhejiang University (China)
Journal: Scientific reports, volume 16, issue 1, article 20485
Dates: received 11 February 2026; accepted 27 April 2026; published online 4 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41598-026-51310-7 · PMID 42082621 · PMCID PMC13328663 · OpenAlex W7160099984
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), mouse (organism), stroke (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Connectivity, Machine learning, Spectral & time-frequency
Keywords: Intracerebral hemorrhage, Neuroinflammation, BTK, Microglia, RNA-sequencing, WGCNA, Immunology, Neurology, Neuroscience
MeSH: Agammaglobulinaemia Tyrosine Kinase*, Cerebral Hemorrhage*, Microglia*, Neuroinflammatory Diseases*, Adenine, Animals, Disease Models, Animal, Gene Expression Profiling, Gene Regulatory Networks, Male, Mice, Mice, Inbred C57BL, Piperidines, Protein Interaction Maps (* major topic)
Topic: Intracerebral and Subarachnoid Hemorrhage Research (Neurology, Medicine), according to OpenAlex
Citations: not cited yet (Europe PMC); 80 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41598-026-51310-7.

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 2 authors, 9 keywords, 14 MeSH terms, 76 references.

Cite

This paper

Xia, S., & Chen, G. (2026). BTK promotes neuroinflammation after intracerebral hemorrhage involving hub genes and alterations in microglial functions. Scientific reports, 16(1), 20485. https://doi.org/10.1038/s41598-026-51310-7

BibTeX

@article{xia2026btk,
author = {Xia, Siqi and Chen, Gao},
title = {{BTK promotes neuroinflammation after intracerebral hemorrhage involving hub genes and alterations in microglial functions}},
journal = {Scientific reports},
year = {2026},
month = may,
volume = {16},
number = {1},
pages = {20485},
publisher = {Nature Publishing Group},
issn = {2045-2322},
doi = {10.1038/s41598-026-51310-7},
url = {https://doi.org/10.1038/s41598-026-51310-7},
pmid = {42082621},
pmcid = {PMC13328663}
}

RIS

TY - JOUR
AU - Xia, Siqi
AU - Chen, Gao
TI - BTK promotes neuroinflammation after intracerebral hemorrhage involving hub genes and alterations in microglial functions
T2 - Scientific reports
J2 - Sci Rep
PY - 2026
DA - 2026/05/04
VL - 16
IS - 1
SP - 20485
SN - 2045-2322
PB - Nature Publishing Group
DO - 10.1038/s41598-026-51310-7
UR - https://doi.org/10.1038/s41598-026-51310-7
LA - en
ER -

CSL-JSON

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