OSCR

Hyperlipidemia induces hippocampal inflammation and loss of vascularity and can be rescued by silencing RIPK1.

Overview

Authors: Jonathan Salazar-Leon1,2, Moises Freitas-Andrade3, Violeta Guadarrama-Perez1, Serena Solari1,2, Abagael Hudak1,2, Cameron Stotts1,2, Nancy Simon1, Michèle Geoffrion1, Sue Murray4, Ruth Slack1,5, Baptiste Lacoste3,2,5, Katey J Rayner1,2,6
  1. University of Ottawa Heart Institute, Ottawa, ON Canada
  2. Faculty of Medicine, University of Ottawa, Ottawa, ON Canada
  3. Ottawa Hospital Research Institute, Ottawa, ON Canada
  4. Ionis Pharmaceuticals, Carlsbad, CA USA
  5. Ottawa Brain & Mind Research Institute, University of Ottawa, Ottawa, ON Canada
  6. Vascular Inflammation and Metabolism Laboratory, Department of Biochemistry, Microbiology and Immunology, University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON K1Y 4W7 Canada
Institutions: University of Ottawa (Canada); Ottawa Heart Institute (Canada); Ottawa Hospital Research Institute (Canada); Ionis Pharmaceuticals (United States) (United States); uOttawa Brain and Mind Research Institute
Journal: Scientific reports, volume 16, issue 1, article 28252
Dates: received 10 December 2025; accepted 19 May 2026; published online 20 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41598-026-54533-w · PMID 42321267 · PMCID PMC13558570 · OpenAlex W7165400299
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), Alzheimer's / dementia (population), stroke (population), cellular / molecular (subfield)
Methods: Statistics, Connectivity
Keywords: Cardiovascular diseases, Vascular cognitive impairment, Knockdown, Receptor-interacting protein 1 kinase, Antisense oligonucleotides, Neurovascular unit, Diseases, Neurology, Neuroscience
MeSH: Hippocampus*, Hyperlipidemias*, Inflammation*, Receptor-Interacting Protein Serine-Threonine Kinases*, Animals, Cerebrovascular Circulation, Disease Models, Animal, Female, Gene Silencing, Male, Mice, Mice, Inbred C57BL, Oligonucleotides, Antisense (* major topic)
Topic: Alzheimer's disease research and treatments (Physiology, Medicine), according to OpenAlex
Funding: Canadian Institutes of Health Research; Canada First Research Excellence Fund (Brain-Heart Interconnectome)
Citations: not cited yet (Europe PMC); 72 references in the paper
Research resources: RRID:IMSR_JAX:002052

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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Read it in the paper: doi.org/10.1038/s41598-026-54533-w.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 9 keywords, 13 MeSH terms, 2 funders, 70 references, 1 RRID.

Cite

This paper

Salazar-Leon, J., Freitas-Andrade, M., Guadarrama-Perez, V., Solari, S., Hudak, A., Stotts, C., Simon, N., Geoffrion, M., Murray, S., Slack, R., Lacoste, B., & Rayner, K. J. (2026). Hyperlipidemia induces hippocampal inflammation and loss of vascularity and can be rescued by silencing RIPK1. Scientific reports, 16(1), 28252. https://doi.org/10.1038/s41598-026-54533-w

BibTeX

@article{salazarleon2026hyperlipidemia,
author = {Salazar-Leon, Jonathan and Freitas-Andrade, Moises and Guadarrama-Perez, Violeta and Solari, Serena and Hudak, Abagael and Stotts, Cameron and Simon, Nancy and Geoffrion, Michèle and Murray, Sue and Slack, Ruth and Lacoste, Baptiste and Rayner, Katey J},
title = {{Hyperlipidemia induces hippocampal inflammation and loss of vascularity and can be rescued by silencing RIPK1}},
journal = {Scientific reports},
year = {2026},
month = jun,
volume = {16},
number = {1},
pages = {28252},
publisher = {Nature Publishing Group},
issn = {2045-2322},
doi = {10.1038/s41598-026-54533-w},
url = {https://doi.org/10.1038/s41598-026-54533-w},
pmid = {42321267},
pmcid = {PMC13558570}
}

RIS

TY - JOUR
AU - Salazar-Leon, Jonathan
AU - Freitas-Andrade, Moises
AU - Guadarrama-Perez, Violeta
AU - Solari, Serena
AU - Hudak, Abagael
AU - Stotts, Cameron
AU - Simon, Nancy
AU - Geoffrion, Michèle
AU - Murray, Sue
AU - Slack, Ruth
AU - Lacoste, Baptiste
AU - Rayner, Katey J
TI - Hyperlipidemia induces hippocampal inflammation and loss of vascularity and can be rescued by silencing RIPK1
T2 - Scientific reports
J2 - Sci Rep
PY - 2026
DA - 2026/06/20
VL - 16
IS - 1
SP - 28252
SN - 2045-2322
PB - Nature Publishing Group
DO - 10.1038/s41598-026-54533-w
UR - https://doi.org/10.1038/s41598-026-54533-w
LA - en
ER -

CSL-JSON

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