Retrograde transduction of dopaminergic cells in substantia nigra of the rhesus monkey.
Overview
- Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 USA
- Nash Family Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029 USA
- Lipschultz Center for Cognitive Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029 USA
- Scientific and Statistical Computing Core, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 USA
- Division of Neuroscience, Oregon National Primate Research Center, Beaverton, OR USA
- Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA USA
- Division of Developmental and Cognitive Neuroscience, Emory National Primate Research Center, Atlanta, GA USA
- Cellular Neurophysiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 USA
- Aligning Science Across Parkinson’s (ASAP) Collaborative Research Network, Chevy Chase, MD 20815 USA
- Biosciences Institute, Newcastle University, Newcastle Upon Tyne, NE1 7RU UK
Abstract
Recent advances in molecular tools have changed how researchers approach selective neural modulation, especially in rodent models where germline modifications and viral vector delivery are readily optimized. However, these tools have not advanced as rapidly for nonhuman primates, despite critical need for translational gene therapy models. A key barrier is targeting specific neuronal populations in the larger primate brain with cell-type and circuit specificity. Dopaminergic neurons pose a particular challenge due to their inaccessible ventral midbrain location, where local injection non-selectively targets all dopaminergic neurons. This work provides NHP researchers with a comparison of retrograde viral vectors, highlighting one which achieves efficient dopaminergic neuron transduction, establishing a foundation for combining vectors with cell-type-specific enhancers for basic and translational applications.
Supplementary Information: The online version contains supplementary material available at https://
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- figshare:30898529, at figshare; found in “Data availability”
Data availability
The raw data reported in the main text are available online through Figshare (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 10 keywords, 7 MeSH terms, 4 funders, 59 references, 2 RRIDs.
Cite
This paper
Plotnikova, A. S., Lerchner, W., Cummins, A. C., Chen, G., Salhani, L., Costa, V. D., Averbeck, B. B., Richmond, B. J., Khaliq, Z. M., & Eldridge, M. A. G. (2026). Retrograde transduction of dopaminergic cells in substantia nigra of the rhesus monkey. Scientific reports, 16(1), 27492. https://
BibTeX
@article{plotnikova2026r
author = {Plotnikova, Anya S and Lerchner, Walter and Cummins, Alexander C and Chen, Gang and Salhani, Leonardo and Costa, Vincent D and Averbeck, Bruno B and Richmond, Barry J and Khaliq, Zayd M and Eldridge, Mark A G},
title = {{Retrograde transduction of dopaminergic cells in substantia nigra of the rhesus monkey}},
journal = {Scientific reports},
year = {2026},
month = jun,
volume = {16},
number = {1},
pages = {27492},
publisher = {Nature Publishing Group},
issn = {2045-2322},
doi = {10.1038/
url = {https://
pmid = {42304030},
pmcid = {PMC13534416}
}
RIS
TY - JOUR
AU - Plotnikova, Anya S
AU - Lerchner, Walter
AU - Cummins, Alexander C
AU - Chen, Gang
AU - Salhani, Leonardo
AU - Costa, Vincent D
AU - Averbeck, Bruno B
AU - Richmond, Barry J
AU - Khaliq, Zayd M
AU - Eldridge, Mark A G
TI - Retrograde transduction of dopaminergic cells in substantia nigra of the rhesus monkey
T2 - Scientific reports
J2 - Sci Rep
PY - 2026
DA - 2026/
VL - 16
IS - 1
SP - 27492
SN - 2045-2322
PB - Nature Publishing Group
DO - 10.1038/
UR - https://
LA - en
ER -
CSL-JSON
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