OSCR

Topological modeling of gene expression in the brain with Huntington's disease reveals selective disruption of co-expression network.

Overview

Authors: Yuko Okamura-Oho1,2, Kazuro Shimokawa3, Satoshi Oota1,4, Atsushi Yoshiki4, Masahiko Morita1, Masaomi Nishimura1, Sakiko Nakamura1, Yuki Tsujimura1, Shumpei Ishikawa3, Hideo Yokota1
  1. RIKEN Center for Advanced Photonics, Wako, 351-0198 Saitama Japan
  2. Faculty of Food Sciences and Nutrition, Jissen Women’s University, Hino, 191- 8510 Tokyo Japan
  3. Department of Preventive Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan
  4. RIKEN Bioresource Research Center, Tsukuba, Ibaraki Japan
Institutions: Jissen Women's University (Japan); RIKEN Center for Advanced Photonics (Japan); The University of Tokyo (Japan); RIKEN BioResource Research Center (Japan)
Journal: Scientific reports, volume 16, issue 1, article 18328
Dates: received 14 November 2025; accepted 28 May 2026; published online 30 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41598-026-56101-8 · PMID 42380167 · PMCID PMC13319467 · OpenAlex W7166670214
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), human (organism), mouse (organism), other condition (population), cellular / molecular (subfield)
Methods: Connectivity
Keywords: Computational biology and bioinformatics, Genetics, Molecular biology, Neurology, Neuroscience
MeSH: Brain*, Gene Expression Regulation*, Gene Regulatory Networks*, Huntington Disease*, Animals, Brain-Derived Neurotrophic Factor, Disease Models, Animal, DNA Helicases, Gene Expression Profiling, Humans, Huntingtin Protein, LIM-Homeodomain Proteins, Medium Spiny Neurons, Mice, Mice, Transgenic, Nerve Tissue Proteins, Nuclear Proteins, Transcription Factors (* major topic)
Topic: Genetic Neurodegenerative Diseases (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: Japan Society for the Promotion of Science (25560428, 26280110, 268032, 15HP8038, 16HP8032, and 17HP8082, JP15H05954)
Citations: not cited yet (Europe PMC); 50 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

Tracing map

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41598-026-56101-8.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 5 keywords, 18 MeSH terms, 1 funder, 50 references.

Cite

This paper

Okamura-Oho, Y., Shimokawa, K., Oota, S., Yoshiki, A., Morita, M., Nishimura, M., Nakamura, S., Tsujimura, Y., Ishikawa, S., & Yokota, H. (2026). Topological modeling of gene expression in the brain with Huntington's disease reveals selective disruption of co-expression network. Scientific reports, 16(1), 18328. https://doi.org/10.1038/s41598-026-56101-8

BibTeX

@article{okamuraoho2026topological,
author = {Okamura-Oho, Yuko and Shimokawa, Kazuro and Oota, Satoshi and Yoshiki, Atsushi and Morita, Masahiko and Nishimura, Masaomi and Nakamura, Sakiko and Tsujimura, Yuki and Ishikawa, Shumpei and Yokota, Hideo},
title = {{Topological modeling of gene expression in the brain with Huntington's disease reveals selective disruption of co-expression network}},
journal = {Scientific reports},
year = {2026},
month = jun,
volume = {16},
number = {1},
pages = {18328},
publisher = {Nature Publishing Group},
issn = {2045-2322},
doi = {10.1038/s41598-026-56101-8},
url = {https://doi.org/10.1038/s41598-026-56101-8},
pmid = {42380167},
pmcid = {PMC13319467}
}

RIS

TY - JOUR
AU - Okamura-Oho, Yuko
AU - Shimokawa, Kazuro
AU - Oota, Satoshi
AU - Yoshiki, Atsushi
AU - Morita, Masahiko
AU - Nishimura, Masaomi
AU - Nakamura, Sakiko
AU - Tsujimura, Yuki
AU - Ishikawa, Shumpei
AU - Yokota, Hideo
TI - Topological modeling of gene expression in the brain with Huntington's disease reveals selective disruption of co-expression network
T2 - Scientific reports
J2 - Sci Rep
PY - 2026
DA - 2026/06/30
VL - 16
IS - 1
SP - 18328
SN - 2045-2322
PB - Nature Publishing Group
DO - 10.1038/s41598-026-56101-8
UR - https://doi.org/10.1038/s41598-026-56101-8
LA - en
ER -

CSL-JSON

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