Fibronectin mediates APOE4-driven blood-brain barrier dysfunction in Alzheimer's disease.

1. Department of Neurology, Columbia University Irving Medical Center, New York, NY USA
2. Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY USA
3. New York Genome Center, New York, NY USA
4. Neural Stem Cell Institute, Albany, NY USA
5. Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY USA
6. Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY USA
7. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA
8. Bordeaux Population Health Research Center, University of Bordeaux, Inserm, UMR 1219, Bordeaux, France
9. German Center for Neurodegenerative Diseases (DZNE), Dresden, Germany
10. Department of Neuroscience, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey
11. Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY USA
12. Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Irving Medical Center, New York, NY USA
13. Department of Quantitative Health Sciences, Mayo Clinic Florida, Jacksonville, FL USA
14. B CUBE Center for Molecular Bioengineering, Technische Universität Dresden, Dresden, Germany
15. National Key Laboratory of Immunity and Inflammation, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College, Suzhou, China
16. Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY USA
17. Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT USA
18. Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL USA
19. Leibniz Institute of Polymer Research Dresden, Max Bergmann Center of Biomaterials Dresden, Dresden, Germany
20. Department of Neurology, Mayo Clinic Florida, Jacksonville, FL USA
21. Institut du Cerveau (ICM), Paris Brain Institute, INSERM U1127, UMR CNRS 7225, Paris, France
22. Department of Neurology, Bordeaux University Hospital, Bordeaux, France
23. Assistance Publique des Hôpitaux de Paris, Sorbonne Université, Paris, France
24. Department of Psychiatry, Columbia University Irving Medical Center, New York, NY USA
25. Department of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, New York, NY USA

@article{bhattarai2026fibronectin,
author = {Bhattarai, Prabesh and Yilmaz, Elanur and Cakir, Elif Öykü and Tayran, Huseyin and Haq, Imdadul and Murphy, Dylan and Keller, Jonah Nadelmann and Le Grand, Quentin and Eschbach, Jacqueline O and Celikkaya, Hilal and Cosacak, Mehmet I and Yüceer Korkmaz, Hande and Lee, Annie J and Haage, Verena and Ma, Yiyi and Wang, Xue and Nelson, Nastasia and Lin, Weilin and Zhang, Yixin and Turgutalp, Bengisu and de Leeuw, Sherida M and Patel, Ronak and Jülich, Dörthe and İş, Özkan and Holley, Scott A and De Jager, Philip L and Freudenberg, Uwe and Werner, Carsten and St George-Hyslop, Peter and Ertekin-Taner, Nilüfer and Debette, Stéphanie and Elahi, Fanny M and Fisher, Elizabeth S and Phatnani, Hemali and Teich, Andrew F and Tubbesing, Kate and Bertucci, Taylor and Temple, Sally and Nuriel, Tal and Vardarajan, Badri N and Mayeux, Richard and Kizil, Caghan},
title = {{Fibronectin mediates APOE4-driven blood-brain barrier dysfunction in Alzheimer's disease}},
journal = {Nature aging},
year = {2026},
month = sep,
volume = {6},
number = {9},
pages = {1901--1927},
publisher = {Nature Portfolio},
issn = {2662-8465},
doi = {10.1038/s43587-026-01204-0},
url = {https://doi.org/10.1038/s43587-026-01204-0},
pmid = {42728404},
pmcid = {PMC13577929}
}

TY - JOUR
AU - Bhattarai, Prabesh
AU - Yilmaz, Elanur
AU - Cakir, Elif Öykü
AU - Tayran, Huseyin
AU - Haq, Imdadul
AU - Murphy, Dylan
AU - Keller, Jonah Nadelmann
AU - Le Grand, Quentin
AU - Eschbach, Jacqueline O
AU - Celikkaya, Hilal
AU - Cosacak, Mehmet I
AU - Yüceer Korkmaz, Hande
AU - Lee, Annie J
AU - Haage, Verena
AU - Ma, Yiyi
AU - Wang, Xue
AU - Nelson, Nastasia
AU - Lin, Weilin
AU - Zhang, Yixin
AU - Turgutalp, Bengisu
AU - de Leeuw, Sherida M
AU - Patel, Ronak
AU - Jülich, Dörthe
AU - İş, Özkan
AU - Holley, Scott A
AU - De Jager, Philip L
AU - Freudenberg, Uwe
AU - Werner, Carsten
AU - St George-Hyslop, Peter
AU - Ertekin-Taner, Nilüfer
AU - Debette, Stéphanie
AU - Elahi, Fanny M
AU - Fisher, Elizabeth S
AU - Phatnani, Hemali
AU - Teich, Andrew F
AU - Tubbesing, Kate
AU - Bertucci, Taylor
AU - Temple, Sally
AU - Nuriel, Tal
AU - Vardarajan, Badri N
AU - Mayeux, Richard
AU - Kizil, Caghan
TI - Fibronectin mediates APOE4-driven blood-brain barrier dysfunction in Alzheimer's disease
T2 - Nature aging
J2 - Nat Aging
PY - 2026
DA - 2026/09/11
VL - 6
IS - 9
SP - 1901
EP - 1927
SN - 2662-8465
PB - Nature Portfolio
DO - 10.1038/s43587-026-01204-0
UR - https://doi.org/10.1038/s43587-026-01204-0
LA - en
ER -

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