Psc and Su(z)2 safeguard intestinal stem cell identity and prevent chinmo-dependent tumorigenesis.
Overview
- National Institute of Biological Sciences, No. 7 Science Park Road, Zhongguancun Life Science Park, Beijing, 102206 China
- School of Life Sciences, Peking University, Beijing, 100871 China
- Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, 102206 China
Abstract
Polycomb group (PcG) genes are epigenetic silencers that maintain transcriptional repression of target genes essential for normal development. However, their roles in adult multipotent stem cell lineages remain poorly understood. Here, we show that simultaneous loss of the PRC1 component Psc and its homolog Su(z)2 in intestinal stem cells (ISCs) of the adult Drosophila midgut leads to tumor formation composed of proliferative, undifferentiated cells. Strikingly, these tumor cells do not activate proliferation-associated
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
The paper links to its data, not to its authors' code: see the Data section.
The paper's code and data availability statement is in the Data section.
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Data
Datasets cited
- geo:GSE299390, at NCBI GEO; found in “Data availability”
Other data links
- ebi.ac.uk/
biostudies/ , EMBL-EBI; found in the text, “Author contributions”sourcedata
Data availability
The datasets produced in this study are available at the Gene Expression Omnibus with the accession code GSE299390 (https://
The source data of this paper are collected in the following database record: biostudies:S-SCDT-10_103
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 4 keywords, 14 MeSH terms, 2 funders, 65 references.
Cite
This paper
Wei, R., Yu, H., Sun, Q., Zhang, Y., Yu, Y., & Xi, R. (2026). Psc and Su(z)2 safeguard intestinal stem cell identity and prevent chinmo-dependent tumorigenesis. EMBO reports, 27(15), 4433-4461. https://
BibTeX
@article{wei2026psc,
author = {Wei, Ruxue and Yu, Haimeng and Sun, Qingyu and Zhang, Yongchao and Yu, Yaxin and Xi, Rongwen},
title = {{Psc and Su(z)2 safeguard intestinal stem cell identity and prevent chinmo-dependent tumorigenesis}},
journal = {EMBO reports},
year = {2026},
month = jun,
volume = {27},
number = {15},
pages = {4433--4461},
publisher = {Nature Publishing Group},
issn = {1469-221X},
doi = {10.1038/
url = {https://
pmid = {42323466},
pmcid = {PMC13458361}
}
RIS
TY - JOUR
AU - Wei, Ruxue
AU - Yu, Haimeng
AU - Sun, Qingyu
AU - Zhang, Yongchao
AU - Yu, Yaxin
AU - Xi, Rongwen
TI - Psc and Su(z)2 safeguard intestinal stem cell identity and prevent chinmo-dependent tumorigenesis
T2 - EMBO reports
J2 - EMBO Rep
PY - 2026
DA - 2026/
VL - 27
IS - 15
SP - 4433
EP - 4461
SN - 1469-221X
PB - Nature Publishing Group
DO - 10.1038/
UR - https://
LA - en
ER -
CSL-JSON
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"family": "Wei",
"given": "Ruxue"
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{
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"given": "Qingyu"
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{
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"given": "Yongchao"
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}
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"page": "4433-4461",
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"ISSN": "1469-221X",
"publisher": "Nature Publishing Group",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
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2026,
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}
}
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