Endothelial KLF4 depletion drives age-related neurovascular dysfunction and neuropsychiatric impairment.

1. Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106
2. Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH 44106
3. Geriatric Psychiatry, Geriatric Research Education and Clinical Center, Louis Stokes VA Medical Center, Cleveland, OH 44106
4. Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH 44106
5. Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106
6. Department of Physiology, Pharmacology and Therapeutics, Johns Hopkins University School of Medicine, Baltimore, MD 44106
7. Department of Molecular Biology, Cell Biology and Biochemistry, Division of Biology and Medicine, Brown University, Providence, RI 02912
8. Hathaway Brown School, Shaker Heights, OH 44122
9. Massachusetts Institute of Technology, Cambridge, MA 02139
10. Department of Pathology, Case Western Reserve University, Cleveland, OH 44106
11. University of California, Santa Barbara, CA 93106
12. Northeastern University, Boston, MA 02115
13. Cate School, Carpinteria, CA 93013
14. College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08226, Republic of Korea
15. Yueyang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
16. Trailhead Biosystems Inc., Beechwood, OH 44122
17. Department of Biomedical Sciences, Northeast Ohio Medical University, Rootstown, OH 44272
18. Glenn Bigg’s Institute for Alzheimer’s and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX 78249
19. Department of Pathology, UT Health Science Center at San Antonio, San Antonio, TX 78249
20. Mesulam Center for Cognitive Neurology and Alzheimer’s Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611
21. Departments of Medicine and Cell and Developmental Biology, Penn Cardiovascular Institute, Penn Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
22. Division of Infectious Diseases and HIV Medicine in the Department of Medicine, Case Western Reserve University, Cleveland, OH 44106
23. Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21218
24. The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21218
25. Lieber Institute for Brain Development, Baltimore, MD 21218
26. Department of Molecular Biology, Cell Biology and Biochemistry, The Warren Alpert Medical School, Brown University, Providence, RI 02912

@article{dhar2026endothelial,
author = {Dhar, Matasha and Vázquez-Rosa, Edwin and Chaubey, Kalyani and Miller, Emiko and Corella, Sofia G. and Chakraborty, Suwarna and Tripathi, Sunil Jamuna and Das, Tapatee and Liao, Xudong and Alosman, Mohamed Alkassem and Fang, Hua and Koh, Yeojung and Sridharan, Preethy S. and Franke, Kathryn and Cintrón-Pérez, Coral J. and Cintrón-Pérez, Adrian A. and Tomco, Taylor and Indrakumar, Vidya and Rubin, Phoebe J. and Pieper, Justin G. and Ashiku, Luke A. and Shin, Min-Kyoo and Tang, Xinmiao and Padmanabhan, Roshan and Haragopal, Hariprakash and Flanagan, Margaret E. and Jain, Rajan and Winters, Bradley D. and Wilson, Brigid M. and Paul, Bindu D. and Jain, Mukesh K. and Pieper, Andrew A.},
title = {{Endothelial KLF4 depletion drives age-related neurovascular dysfunction and neuropsychiatric impairment}},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2026},
month = jun,
volume = {123},
number = {25},
pages = {e2426990123},
publisher = {National Academy of Sciences},
issn = {0027-8424},
doi = {10.1073/pnas.2426990123},
url = {https://doi.org/10.1073/pnas.2426990123},
pmid = {42313933},
pmcid = {PMC13291589}
}

TY - JOUR
AU - Dhar, Matasha
AU - Vázquez-Rosa, Edwin
AU - Chaubey, Kalyani
AU - Miller, Emiko
AU - Corella, Sofia G.
AU - Chakraborty, Suwarna
AU - Tripathi, Sunil Jamuna
AU - Das, Tapatee
AU - Liao, Xudong
AU - Alosman, Mohamed Alkassem
AU - Fang, Hua
AU - Koh, Yeojung
AU - Sridharan, Preethy S.
AU - Franke, Kathryn
AU - Cintrón-Pérez, Coral J.
AU - Cintrón-Pérez, Adrian A.
AU - Tomco, Taylor
AU - Indrakumar, Vidya
AU - Rubin, Phoebe J.
AU - Pieper, Justin G.
AU - Ashiku, Luke A.
AU - Shin, Min-Kyoo
AU - Tang, Xinmiao
AU - Padmanabhan, Roshan
AU - Haragopal, Hariprakash
AU - Flanagan, Margaret E.
AU - Jain, Rajan
AU - Winters, Bradley D.
AU - Wilson, Brigid M.
AU - Paul, Bindu D.
AU - Jain, Mukesh K.
AU - Pieper, Andrew A.
TI - Endothelial KLF4 depletion drives age-related neurovascular dysfunction and neuropsychiatric impairment
T2 - Proceedings of the National Academy of Sciences of the United States of America
J2 - Proc Natl Acad Sci U S A
PY - 2026
DA - 2026/06/18
VL - 123
IS - 25
SP - e2426990123
SN - 0027-8424
PB - National Academy of Sciences
DO - 10.1073/pnas.2426990123
UR - https://doi.org/10.1073/pnas.2426990123
LA - en
ER -

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