OSCR

Transcriptional analyses identify pericyte-centered signaling programs altered by sex and brain region in Alzheimer's Disease.

Overview

Authors: Kareem El-Ghazawi1,2, Yonathan T Aberra1,3, Yashasvisai Veeramasu1, Wisam A Fares1, Brant E Isakson4,5, Harald Sontheimer6, Ukpong B Eyo6,7, Shayn M Peirce1
ORCID iDs: Kareem El-Ghazawi, Yonathan T Aberra, Ukpong B Eyo
  1. Department of Biomedical Engineering, University of Virginia, Charlottesville, VA USA
  2. Brain Institute, University of Virginia School of Medicine, Charlottesville, VA USA
  3. Department of Genome Sciences, University of Virginia School of Medicine, Charlottesville, VA USA
  4. Robert M Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA USA
  5. Department of Molecular Physiology and Biophysics, University of Virginia School of Medicine, Charlottesville, VA USA
  6. Department of Neuroscience, University of Virginia, Charlottesville, VA USA
  7. Brain, Immunology, and Glia Center, University of Virginia School of Medicine, Charlottesville, VA USA
Institutions: University of Virginia (United States)
Journal: Communications biology, volume 9, issue 1, article 1216
Dates: received 7 August 2025; accepted 29 May 2026; published online 8 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s42003-026-10446-y · PMID 42260160 · PMCID PMC13586196 · OpenAlex W7163872499
Open access: gold, a free copy (OpenAlex)
Status: code verified
Categories: genetics / omics (modality), human (organism), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Statistics
Keywords: Cellular signalling networks, Computational neuroscience, Neuro-vascular interactions
MeSH: Alzheimer Disease*, Brain*, Pericytes*, Signal Transduction*, Aged, Female, Gene Expression Profiling, Humans, Male, Sex Characteristics, Sex Factors, Transcriptome (* major topic)
Topic: Alzheimer's disease research and treatments (Physiology, Medicine), according to OpenAlex
Funding: NHLBI NIH HHS (R01 HL137112)
Citations: not cited yet (Europe PMC); 78 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

No file of the authors' code could be read here: it is described below, and read at its source.

ccc-protocols.readthedocs.io

License: none: the authors keep all their rights
State: the link answers, verified on 27 September 2026
Evidence: the link answers
Software Heritage: not checked
Found in: “Code availability”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 27 September 2026: the link answers (HTTP 200)
  • 27 September 2026: the link answers (HTTP 200)
At the source: ccc-protocols.readthedocs.io/en/latest/index.html

Zenodo 16760785

License: CC-BY-4.0
State: the link answers, verified on 27 September 2026
Evidence: files inventoried
Size: 0 files, 0 scripts
Software Heritage: not checked
Found in: “Code availability”
Not found: README, license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 27 September 2026: the link answers (HTTP 200)
  • 27 September 2026: the link answers (HTTP 200)
At the source:

Code availability statement

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Read it in the paper: doi.org/10.1038/s42003-026-10446-y.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 2 repositories of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 0 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s42003-026-10446-y.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 3 keywords, 12 MeSH terms, 1 funder, 74 references.

Cite

This paper

El-Ghazawi, K., Aberra, Y. T., Veeramasu, Y., Fares, W. A., Isakson, B. E., Sontheimer, H., Eyo, U. B., & Peirce, S. M. (2026). Transcriptional analyses identify pericyte-centered signaling programs altered by sex and brain region in Alzheimer's Disease. Communications biology, 9(1), 1216. https://doi.org/10.1038/s42003-026-10446-y

BibTeX

@article{elghazawi2026transcriptional,
author = {El-Ghazawi, Kareem and Aberra, Yonathan T and Veeramasu, Yashasvisai and Fares, Wisam A and Isakson, Brant E and Sontheimer, Harald and Eyo, Ukpong B and Peirce, Shayn M},
title = {{Transcriptional analyses identify pericyte-centered signaling programs altered by sex and brain region in Alzheimer's Disease}},
journal = {Communications biology},
year = {2026},
month = jun,
volume = {9},
number = {1},
pages = {1216},
publisher = {Nature Publishing Group},
issn = {2399-3642},
doi = {10.1038/s42003-026-10446-y},
url = {https://doi.org/10.1038/s42003-026-10446-y},
pmid = {42260160},
pmcid = {PMC13586196}
}

RIS

TY - JOUR
AU - El-Ghazawi, Kareem
AU - Aberra, Yonathan T
AU - Veeramasu, Yashasvisai
AU - Fares, Wisam A
AU - Isakson, Brant E
AU - Sontheimer, Harald
AU - Eyo, Ukpong B
AU - Peirce, Shayn M
TI - Transcriptional analyses identify pericyte-centered signaling programs altered by sex and brain region in Alzheimer's Disease
T2 - Communications biology
J2 - Commun Biol
PY - 2026
DA - 2026/06/08
VL - 9
IS - 1
SP - 1216
SN - 2399-3642
PB - Nature Publishing Group
DO - 10.1038/s42003-026-10446-y
UR - https://doi.org/10.1038/s42003-026-10446-y
LA - en
ER -

CSL-JSON

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