OSCR

Hypothalamic endoplasmic reticulum stress drives pubertal precocity due to early-onset obesity in female rodents.

Overview

Authors: Elvira Rodríguez-Vázquez1,2,3, Álvaro Aranda-Torrecillas1,2,3, Manuel Jiménez-Puyer1,2,3, Oscar Freire-Agulleiro4,5, María J. Sánchez-Tapia1,2, Miguel Ruiz-Cruz1,2, Violeta Heras1,2, María López-Sancho1,2, Luisina Ongaro6, Cecilia Perdices-López1,2, Daniel J. Bernard6,7, Rafael Pineda1,2,4, Francisco Gaytan1,2, Miguel López4,5, Juan M. Castellano1,2,3,4, Manuel Tena-Sempere1,2,3,4
ORCID iDs: Elvira Rodríguez-Vázquez, Álvaro Aranda-Torrecillas, Manuel Jiménez-Puyer, Oscar Freire-Agulleiro, María J. Sánchez-Tapia, Miguel Ruiz-Cruz, Violeta Heras, Cecilia Perdices-López, Daniel J. Bernard, Rafael Pineda, Miguel López, Juan M. Castellano, Manuel Tena-Sempere
  1. Instituto Maimónides de Investigación Biomédica de Córdoba, Córdoba 14004, Spain
  2. Department of Cell Biology, Physiology and Immunology, University of Córdoba, Cordoba 14004, Spain
  3. Hospital Universitario Reina Sofía, Córdoba 14004, Spain
  4. Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Córdoba 14004, Spain
  5. NeurObesity Group, Department of Physiology, Centro de Investigación en Medicina Molecular y Enfermedades Crónicas, University of Santiago de Compostela, Santiago de Compostela 15782, Spain
  6. Department of Pharmacology and Therapeutics, McGill University, Montréal, Quebec H3G 1Y6, Canada
  7. Department of Anatomy and Cell Biology, McGill University, Montréal, Quebec H3A 0C7, Canada
Institutions: Instituto Maimónides de Investigación Biomédica de Córdoba (Spain); Hospital Universitario Reina Sofía (Spain); University of Córdoba (Spain); Universidade de Santiago de Compostela (Spain); Instituto de Salud Carlos III (Spain); Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (Spain); Centro de Investigación Biomédica en Red (Spain); McGill University (Canada)
Journal: Proceedings of the National Academy of Sciences of the United States of America, volume 123, issue 11, article e2510886123
Dates: received 1 May 2025; accepted 9 February 2026; published online 12 March 2026; in print 17 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1073/pnas.2510886123 · PMID 41818156 · PMCID PMC12994197 · OpenAlex W7135039271
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: mouse (organism), rat (organism), other condition (population), developmental (subfield)
Methods: Statistics, Evoked potentials
Keywords: puberty, ER stress, Kiss1 neurons, obesity, hypothalamus
MeSH: Endoplasmic Reticulum Stress*, Hypothalamus*, Obesity*, Sexual Maturation*, Activating Transcription Factor 6, Animals, Arcuate Nucleus of Hypothalamus, eIF-2 Kinase, Endoplasmic Reticulum Chaperone BiP, Female, Heat-Shock Proteins, Rats, Thapsigargin (* major topic)
Journal subjects: Biological Sciences, Physiology
Topic: Endoplasmic Reticulum Stress and Disease (Cell Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Ministry of Economy and Competitiveness | Agencia Estatal de Investigación (Spanish Agencia Estatal de Investigación) (PID2023-149244NB-I00, PID2020-118660GB-I00, PID2021-128372OB-I00, PID2021-128145NB-I00, RYC2019-027938-I); EC | Horizon Europe | Excellent Science | HORIZON EUROPE European Research Council (ERC) (HE-ERC-2022-ADG-101096793); EC | HORIZON EUROPE Framework Programme (Horizon Europe) (GAP-101080219); Canadian Institutes of Health Research (-Canadian Institutes of Health ResearcProject Grant PJT-195832)
Citations: cited by 2 papers (Europe PMC); 60 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

The paper's code and data availability statement is in the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none, so it has no map.

Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1073/pnas.2510886123.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 16 authors, 5 keywords, 13 MeSH terms, 4 funders, 60 references.

Cite

This paper

Rodríguez-Vázquez, E., Aranda-Torrecillas, Á., Jiménez-Puyer, M., Freire-Agulleiro, O., Sánchez-Tapia, M. J., Ruiz-Cruz, M., Heras, V., López-Sancho, M., Ongaro, L., Perdices-López, C., Bernard, D. J., Pineda, R., Gaytan, F., López, M., Castellano, J. M., & Tena-Sempere, M. (2026). Hypothalamic endoplasmic reticulum stress drives pubertal precocity due to early-onset obesity in female rodents. Proceedings of the National Academy of Sciences of the United States of America, 123(11), e2510886123. https://doi.org/10.1073/pnas.2510886123

BibTeX

@article{rodriguezvazquez2026hypothalamic,
author = {Rodríguez-Vázquez, Elvira and Aranda-Torrecillas, Álvaro and Jiménez-Puyer, Manuel and Freire-Agulleiro, Oscar and Sánchez-Tapia, María J. and Ruiz-Cruz, Miguel and Heras, Violeta and López-Sancho, María and Ongaro, Luisina and Perdices-López, Cecilia and Bernard, Daniel J. and Pineda, Rafael and Gaytan, Francisco and López, Miguel and Castellano, Juan M. and Tena-Sempere, Manuel},
title = {{Hypothalamic endoplasmic reticulum stress drives pubertal precocity due to early-onset obesity in female rodents}},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2026},
month = mar,
volume = {123},
number = {11},
pages = {e2510886123},
publisher = {National Academy of Sciences},
issn = {0027-8424},
doi = {10.1073/pnas.2510886123},
url = {https://doi.org/10.1073/pnas.2510886123},
pmid = {41818156},
pmcid = {PMC12994197}
}

RIS

TY - JOUR
AU - Rodríguez-Vázquez, Elvira
AU - Aranda-Torrecillas, Álvaro
AU - Jiménez-Puyer, Manuel
AU - Freire-Agulleiro, Oscar
AU - Sánchez-Tapia, María J.
AU - Ruiz-Cruz, Miguel
AU - Heras, Violeta
AU - López-Sancho, María
AU - Ongaro, Luisina
AU - Perdices-López, Cecilia
AU - Bernard, Daniel J.
AU - Pineda, Rafael
AU - Gaytan, Francisco
AU - López, Miguel
AU - Castellano, Juan M.
AU - Tena-Sempere, Manuel
TI - Hypothalamic endoplasmic reticulum stress drives pubertal precocity due to early-onset obesity in female rodents
T2 - Proceedings of the National Academy of Sciences of the United States of America
J2 - Proc Natl Acad Sci U S A
PY - 2026
DA - 2026/03/12
VL - 123
IS - 11
SP - e2510886123
SN - 0027-8424
PB - National Academy of Sciences
DO - 10.1073/pnas.2510886123
UR - https://doi.org/10.1073/pnas.2510886123
LA - en
ER -

CSL-JSON

{
"id": "10.1073/pnas.2510886123",
"type": "article-journal",
"title": "Hypothalamic endoplasmic reticulum stress drives pubertal precocity due to early-onset obesity in female rodents",
"container-title": "Proceedings of the National Academy of Sciences of the United States of America",
"author": [
{
"family": "Rodríguez-Vázquez",
"given": "Elvira"
},
{
"family": "Aranda-Torrecillas",
"given": "Álvaro"
},
{
"family": "Jiménez-Puyer",
"given": "Manuel"
},
{
"family": "Freire-Agulleiro",
"given": "Oscar"
},
{
"family": "Sánchez-Tapia",
"given": "María J."
},
{
"family": "Ruiz-Cruz",
"given": "Miguel"
},
{
"family": "Heras",
"given": "Violeta"
},
{
"family": "López-Sancho",
"given": "María"
},
{
"family": "Ongaro",
"given": "Luisina"
},
{
"family": "Perdices-López",
"given": "Cecilia"
},
{
"family": "Bernard",
"given": "Daniel J."
},
{
"family": "Pineda",
"given": "Rafael"
},
{
"family": "Gaytan",
"given": "Francisco"
},
{
"family": "López",
"given": "Miguel"
},
{
"family": "Castellano",
"given": "Juan M."
},
{
"family": "Tena-Sempere",
"given": "Manuel"
}
],
"container-title-short": "Proc Natl Acad Sci U S A",
"volume": "123",
"issue": "11",
"page": "e2510886123",
"DOI": "10.1073/pnas.2510886123",
"PMID": "41818156",
"PMCID": "PMC12994197",
"ISSN": "0027-8424",
"publisher": "National Academy of Sciences",
"URL": "https://doi.org/10.1073/pnas.2510886123",
"language": "en",
"issued": {
"date-parts": [
[
2026,
3,
12
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1038/s42255-026-01555-3 [code]
The perineurium integrates leptin with its sympathetic outflow to protect against obesity.
Journal: Nature metabolism
In common: other condition, mouse, 1 reference, author Miguel López
[2] doi:10.1126/science.aeb6999
Microglia Rank signaling regulates GnRH neuronal function and the hypothalamic-pituitary-gonadal axis.
Journal: Science (New York, N.Y.)
In common: mouse, author Manuel Tena-Sempere
[3] doi: [code]
Transcript architecture predetermines m6A remodeling and sensory neuron vulnerability in chemotherapy-induced peripheral neuropathy
Journal: bioRxiv : the preprint server for biology
In common: other condition, mouse, 1 reference
[4] doi:10.1080/21505594.2026.2654261
<i>Toxoplasma gondii</i> effector GRA35 mediates neuronal damage <i>via</i> ER stress and mitochondria-associated apoptosis.
Journal: Virulence
In common: other condition, mouse, 1 reference
[5] doi:10.1038/s41586-026-10290-4
Expansion of outer cortical CUX2 neurons requires adaptations for DNA repair.
Journal: Nature
In common: other condition, mouse, 1 reference
[6] doi:10.1111/jne.70265
Intracerebroventricular injection of neuropeptide Y suppresses luteinizing hormone pulses in mice.
Journal: Journal of neuroendocrinology
In common: mouse, 1 reference
[7] doi:10.1038/s41467-026-74598-5 [code]
A synaptoid connectome differentiates tanycytic subpopulations and underlies neuroglial communication and neuroendocrine regulation.
Journal: Nature communications
In common: mouse, 1 reference
[8] doi:10.1210/endocr/bqag049
Kisspeptin made in the preoptic area is required for normal estradiol-induced LH surges and optimal fertility in females.
Journal: Endocrinology
In common: mouse, 1 reference
[9] doi:10.1073/pnas.2537017123
Distinct cell type-specific mechanisms underlie cognitive dysfunction during persistent integrated stress response activation.
Journal: Proceedings of the National Academy of Sciences of the United States of America
In common: mouse, 1 reference
[10] doi:10.1038/s41380-026-03517-3
Correction of eIF4E overactivation rescues translatome imbalance and core ASD-like behaviors in valproic acid-induced offspring mice.
Journal: Molecular psychiatry
In common: mouse, 1 reference

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.