OSCR

Neuromotor modules revealed by direct electrical stimulation of the human primary motor cortex.

Overview

Authors: Jodie J. Xie1, Subing Huang2, Kelvin Y. S. Lau1, Amy H. S. Kong3, Rosa H. M. Chan2, Peter Y. M. Woo4,5, Vincent C. K. Cheung1,6,7
ORCID iDs: Jodie J. Xie, Rosa H. M. Chan
  1. School of Biomedical Sciences, and The Gerald Choa Neuroscience Institute, The Chinese University of Hong Kong, Hong Kong, China
  2. Department of Electrical Engineering, City University of Hong Kong, Hong Kong, China
  3. Department of Anaesthesiology and Operating Theatre Services, Kwong Wah Hospital, Hong Kong, China
  4. Department of Neurosurgery, Prince of Wales Hospital, Hong Kong, China
  5. Department of Neurosurgery, Kwong Wah Hospital, Hong Kong, China
  6. Joint Laboratory of Bioresources and Molecular Research of Common Diseases, The Chinese University of Hong Kong and Kunming Institute of Zoology of the Chinese Academy of Sciences, Hong Kong, China
  7. The Gerald Choa Neuroscience Institute–Oujiang Laboratory Joint Laboratory for Neuroscience and Neurology, The Chinese University of Hong Kong, Hong Kong, China
Institutions: Chinese University of Hong Kong (Hong Kong SAR China); City University of Hong Kong (Hong Kong SAR China); Kwong Wah Hospital (China); Kunming Institute of Zoology (China)
Journal: Proceedings of the National Academy of Sciences of the United States of America, volume 123, issue 37, article e2604933123
Dates: received 16 March 2026; accepted 13 July 2026; published online 8 September 2026; in print 15 September 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1073/pnas.2604933123 · PMID 42709812 · PMCID PMC13578996 · OpenAlex W7211931768
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: other (modality), human (organism), other condition (population), systems (subfield)
Methods: Machine learning, Physiology & signal measures
Keywords: muscle synergy, surface electromyography, primary motor cortex, neurosurgery
MeSH: Motor Cortex*, Muscle, Skeletal*, Adult, Electric Stimulation, Electromyography, Female, Glioma, Humans, Male, Middle Aged, Movement (* major topic)
Journal subjects: Biological Sciences, Neuroscience
Topic: Muscle activation and electromyography studies (Biomedical Engineering, Engineering), according to OpenAlex
Funding: Hong Kong Resarch Grants Council (14114721 14119022); Chinese University of Hong Kong (3133184 4054652 4054710)
Citations: not cited yet (Europe PMC); 117 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

Datasets cited

Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1073/pnas.2604933123.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 4 keywords, 11 MeSH terms, 2 funders, 112 references.

Cite

This paper

Xie, J. J., Huang, S., Lau, K. Y. S., Kong, A. H. S., Chan, R. H. M., Woo, P. Y. M., & Cheung, V. C. K. (2026). Neuromotor modules revealed by direct electrical stimulation of the human primary motor cortex. Proceedings of the National Academy of Sciences of the United States of America, 123(37), e2604933123. https://doi.org/10.1073/pnas.2604933123

BibTeX

@article{xie2026neuromotor,
author = {Xie, Jodie J. and Huang, Subing and Lau, Kelvin Y. S. and Kong, Amy H. S. and Chan, Rosa H. M. and Woo, Peter Y. M. and Cheung, Vincent C. K.},
title = {{Neuromotor modules revealed by direct electrical stimulation of the human primary motor cortex}},
journal = {Proceedings of the National Academy of Sciences of the United States of America},
year = {2026},
month = sep,
volume = {123},
number = {37},
pages = {e2604933123},
publisher = {National Academy of Sciences},
issn = {0027-8424},
doi = {10.1073/pnas.2604933123},
url = {https://doi.org/10.1073/pnas.2604933123},
pmid = {42709812},
pmcid = {PMC13578996}
}

RIS

TY - JOUR
AU - Xie, Jodie J.
AU - Huang, Subing
AU - Lau, Kelvin Y. S.
AU - Kong, Amy H. S.
AU - Chan, Rosa H. M.
AU - Woo, Peter Y. M.
AU - Cheung, Vincent C. K.
TI - Neuromotor modules revealed by direct electrical stimulation of the human primary motor cortex
T2 - Proceedings of the National Academy of Sciences of the United States of America
J2 - Proc Natl Acad Sci U S A
PY - 2026
DA - 2026/09/08
VL - 123
IS - 37
SP - e2604933123
SN - 0027-8424
PB - National Academy of Sciences
DO - 10.1073/pnas.2604933123
UR - https://doi.org/10.1073/pnas.2604933123
LA - en
ER -

CSL-JSON

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"title": "Neuromotor modules revealed by direct electrical stimulation of the human primary motor cortex",
"container-title": "Proceedings of the National Academy of Sciences of the United States of America",
"author": [
{
"family": "Xie",
"given": "Jodie J."
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{
"family": "Kong",
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{
"family": "Chan",
"given": "Rosa H. M."
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"container-title-short": "Proc Natl Acad Sci U S A",
"volume": "123",
"issue": "37",
"page": "e2604933123",
"DOI": "10.1073/pnas.2604933123",
"PMID": "42709812",
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"ISSN": "0027-8424",
"publisher": "National Academy of Sciences",
"URL": "https://doi.org/10.1073/pnas.2604933123",
"language": "en",
"issued": {
"date-parts": [
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}

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