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Maternal Choline Supplementation in a Mouse Model of Down Syndrome and Alzheimer's Disease Generates Unique Expression Profile Mosaics Within Three Hippocampal Excitatory Neuronal Populations.

Overview

Authors: Melissa J Alldred1,2, Kyrillos W Ibrahim1, Harshitha Pidikiti1, Sang Han Lee1,2, Adriana Heguy3, Gabriela Chiosis4,5, Elliott J Mufson6, Grace E Stutzmann7, Stephen D Ginsberg1,2,8,9
  1. Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York, USA
  2. Department of Psychiatry, New York University Grossman School of Medicine, New York, New York, USA
  3. Genome Technology Center, New York University Grossman School of Medicine, New York, New York, USA
  4. Program in Chemical Biology, Sloan Kettering Institute, New York, New York, USA
  5. Breast Cancer Medicine Service, Memorial Sloan Kettering Cancer Center, New York, New York, USA
  6. Department of Translational Neuroscience and Neurology, Barrow Neurological Institute, Phoenix, Arizona, USA
  7. Center for Neurodegenerative Disease and Therapeutics, Rosalind Franklin University/The Chicago Medical School, North Chicago, Illinois, USA
  8. Department of Neuroscience & Physiology, New York University Grossman School of Medicine, New York, New York, USA
  9. NYU Neuroscience Institute, New York University Grossman School of Medicine, New York, New York, USA
Dates: received 14 November 2025; accepted 17 February 2026; published online 3 April 2026; in print 15 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1096/fj.202504243r · PMID 41930605 · PMCID PMC13047536 · OpenAlex W7148980483
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), mouse (organism), other condition (population), Alzheimer's / dementia (population), systems (subfield)
Methods: Statistics
Keywords: Alzheimer's disease, bioinformatics, Down syndrome, laser capture microdissection, maternal choline supplementation, RNA‐sequencing, Ts65Dn mouse
MeSH: Alzheimer Disease*, Choline*, Down Syndrome*, Hippocampus*, Neurons*, Transcriptome*, Animals, Dietary Supplements, Disease Models, Animal, Female, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Pregnancy (* major topic)
Topic: Down syndrome and intellectual disability research (Public Health, Environmental and Occupational Health, Medicine), according to OpenAlex
Funding: NIH HHS (AG072599, AG074004, AG077103, AG081286, AG085572, AG014449); NCI NIH HHS (P30 CA008748)
Citations: not cited yet (Europe PMC); 139 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Tracing map

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Data

Datasets cited

Other data links

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it points to 2 datasets: NCBI, NCBI GEO GSE283699
  • it says that the data are available on request

Read it in the paper: doi.org/10.1096/fj.202504243r.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Publisher: n/a → Wiley

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 7 keywords, 15 MeSH terms, 2 funders, 133 references.

Cite

This paper

Alldred, M. J., Ibrahim, K. W., Pidikiti, H., Lee, S. H., Heguy, A., Chiosis, G., Mufson, E. J., Stutzmann, G. E., & Ginsberg, S. D. (2026). Maternal Choline Supplementation in a Mouse Model of Down Syndrome and Alzheimer's Disease Generates Unique Expression Profile Mosaics Within Three Hippocampal Excitatory Neuronal Populations. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 40(7), e71625. https://doi.org/10.1096/fj.202504243r

BibTeX

@article{alldred2026maternal,
author = {Alldred, Melissa J and Ibrahim, Kyrillos W and Pidikiti, Harshitha and Lee, Sang Han and Heguy, Adriana and Chiosis, Gabriela and Mufson, Elliott J and Stutzmann, Grace E and Ginsberg, Stephen D},
title = {{Maternal Choline Supplementation in a Mouse Model of Down Syndrome and Alzheimer's Disease Generates Unique Expression Profile Mosaics Within Three Hippocampal Excitatory Neuronal Populations}},
journal = {FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
year = {2026},
month = apr,
volume = {40},
number = {7},
pages = {e71625},
publisher = {Wiley},
issn = {0892-6638},
doi = {10.1096/fj.202504243r},
url = {https://doi.org/10.1096/fj.202504243r},
pmid = {41930605},
pmcid = {PMC13047536}
}

RIS

TY - JOUR
AU - Alldred, Melissa J
AU - Ibrahim, Kyrillos W
AU - Pidikiti, Harshitha
AU - Lee, Sang Han
AU - Heguy, Adriana
AU - Chiosis, Gabriela
AU - Mufson, Elliott J
AU - Stutzmann, Grace E
AU - Ginsberg, Stephen D
TI - Maternal Choline Supplementation in a Mouse Model of Down Syndrome and Alzheimer's Disease Generates Unique Expression Profile Mosaics Within Three Hippocampal Excitatory Neuronal Populations
T2 - FASEB journal : official publication of the Federation of American Societies for Experimental Biology
J2 - FASEB J
PY - 2026
DA - 2026/04/01
VL - 40
IS - 7
SP - e71625
SN - 0892-6638
PB - Wiley
DO - 10.1096/fj.202504243r
UR - https://doi.org/10.1096/fj.202504243r
LA - en
ER -

CSL-JSON

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