Impaired Hearing and Systolic Blood Pressure as Potential Markers of Cerebral Infarction After Eclampsia: A Cross-Sectional Study.
Overview
- Department of Obstetrics and Gynecology Stellenbosch University Cape Town South Africa
- Department of Women's and Children's Health Uppsala University Uppsala Sweden
- Department of Obstetrics and Gynecology, Institute of Clinical Sciences, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden
- Statistiska Konsultgruppen Sweden Gothenburg Sweden
- Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden
- Division of Radiodiagnosis Stellenbosch University Cape Town South Africa
- Department of Medicine, Institute of Clinical and Molecular Medicine, Sahlgrenska Academy University of Gothenburg Gothenburg Sweden
- Division of Cardiology, Faculty of Medicine Stellenbosch University Cape Town South Africa
- Translational Obstetrics Group, Department of Obstetrics and Gynaecology University of Melbourne Melbourne Victoria Australia
- Mercy Perinatal Mercy Hospital for Women Heidelberg Victoria Australia
- Department of Surgical Sciences, Neuroradiology Uppsala University Uppsala Sweden
Abstract
Objective: Eclampsia is associated with short‐ and long‐term neurological deficits. Identifying which women may be at risk is important. Magnetic resonance imaging shows an incidence of 30%–40% of subclinical cerebral infarcts among women with eclampsia. A simple screening tool would be useful to identify at‐risk women. The objective of this study was to explore clinical markers to identify women at highest risk for silent cerebral infarcts in women who have experienced eclampsia.
Design: This was a prospective observational study with cross‐sectional MRI ascertainment conducted at Tygerberg Hospital, a tertiary referral centre in Cape Town, South Africa. Women were prospectively assessed for symptoms and signs known to be associated with eclampsia. Cerebral infarcts were identified using brain magnetic resonance imaging. Associations between clinical variables and the presence of cerebral infarcts were evaluated using logistic regression, with variables significant at the 20% level considered for inclusion in multivariable analyses using stepwise selection.
Results: A total of 49 women with eclampsia were included in the analysis, of whom 33% (n = 16) had cerebral infarcts detected on MRI. Highest systolic blood pressure and impaired hearing prior to the eclamptic seizure were the clinical variables most strongly associated with the presence of silent cerebral infarcts, with an area under the receiver operating characteristic curve of 0.72 (95% CI 0.56–0.88). At a risk threshold of 43%, sensitivity was 60% (95% CI 36%–80%) and specificity was 84% (95% CI 67%–93%).
Conclusions: Higher systolic blood pressure and impaired hearing were the clinical features most strongly associated with silent cerebral infarcts in women with eclampsia. These findings highlight potentially useful clinical markers that, following external validation, may support triage decisions regarding neuroimaging and neurological follow up.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data Availability Statement
Due to participant confidentiality and local legislation, the study data cannot be openly shared. De‐identified data underlying the findings may be made available from the corresponding author and principal investigator upon reasonable request and submission of a written proposal, subject to relevant ethical and legal approvals. The statistical code underlying the analyses and results is available from the corresponding author on request.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 4 keywords, 14 MeSH terms, 9 funders, 33 references.
Cite
This paper
Bergman, L., Imberg, H., Langenegger, E., Moodley, A., Pitcher, R., Griffith‐Richards, S., Bergman, K., Hastie, R., Tong, S., Walker, S. P., Wikström, J., & Cluver, C. (2026). Impaired Hearing and Systolic Blood Pressure as Potential Markers of Cerebral Infarction After Eclampsia: A Cross-Sectional Study. BJOG : an international journal of obstetrics and gynaecology, 133(8), 1679-1688. https://
BibTeX
@article{bergman2026impa
author = {Bergman, Lina and Imberg, Henrik and Langenegger, Eduard and Moodley, Ashley and Pitcher, Richard and Griffith‐Richards, Stephanie and Bergman, Karl and Hastie, Roxanne and Tong, Stephen and Walker, Susan P. and Wikström, Johan and Cluver, Catherine},
title = {{Impaired Hearing and Systolic Blood Pressure as Potential Markers of Cerebral Infarction After Eclampsia: A Cross-Sectional Study}},
journal = {BJOG : an international journal of obstetrics and gynaecology},
year = {2026},
month = mar,
volume = {133},
number = {8},
pages = {1679--1688},
publisher = {Lippincott Williams \& Wilkins},
issn = {1470-0328},
doi = {10.1111/
url = {https://
pmid = {41876090},
pmcid = {PMC13254043}
}
RIS
TY - JOUR
AU - Bergman, Lina
AU - Imberg, Henrik
AU - Langenegger, Eduard
AU - Moodley, Ashley
AU - Pitcher, Richard
AU - Griffith‐Richards, Stephanie
AU - Bergman, Karl
AU - Hastie, Roxanne
AU - Tong, Stephen
AU - Walker, Susan P.
AU - Wikström, Johan
AU - Cluver, Catherine
TI - Impaired Hearing and Systolic Blood Pressure as Potential Markers of Cerebral Infarction After Eclampsia: A Cross-Sectional Study
T2 - BJOG : an international journal of obstetrics and gynaecology
J2 - BJOG
PY - 2026
DA - 2026/
VL - 133
IS - 8
SP - 1679
EP - 1688
SN - 1470-0328
PB - Lippincott Williams & Wilkins
DO - 10.1111/
UR - https://
LA - en
ER -
CSL-JSON
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