OSCR

Atypical Cadherin Fat2 is Involved in Axogenesis of Cerebellar Granule Cells in Zebrafish.

Overview

Authors: Jui Chun Wang1, Miki Takeuchi1, Ryuji Dohaku1, Seok‐Hyung Kim2, Lilianna Solnica‐Krezel2, Takashi Shimizu1, Masahiko Hibi1
ORCID iDs: Jui Chun Wang, Miki Takeuchi, Lilianna Solnica‐Krezel, Takashi Shimizu, Masahiko Hibi
  1. Department of Biological Science, Graduate School of Science Nagoya University Nagoya Japan
  2. Department of Developmental Biology Washington University School of Medicine St. Louis Missouri USA
Institutions: Nagoya University (Japan); Washington University in St. Louis (United States)
Journal: Development, growth & differentiation, volume 68, issue 4-5, article e70060
Dates: received 4 February 2026; accepted 19 May 2026; published online 9 June 2026; in print 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1111/dgd.70060 · PMID 42383708 · PMCID PMC13249537 · OpenAlex W7163985088
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: zebrafish (organism), cellular / molecular (subfield)
Methods: Evoked potentials
MeSH: Axons*, Cadherins*, Cerebellum*, Zebrafish*, Zebrafish Proteins*, Animals, Purkinje Cells (* major topic)
Topic: Wnt/β-catenin signaling in development and cancer (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Japan Society for the Promotion of Science (25K02283, 23K23894, 23K05845); U.S. Department of Health & Human Services | NIH | National Human Genome Research Institute (NHGRI) (R01HG002995); U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) (R35GM118179); Uehara Memorial Foundation
Citations: not cited yet (Europe PMC); 41 references in the paper

Abstract

Fat2 is an atypical cadherin with a large extracellular domain containing multiple cadherin repeats. Although members of the Fat family have been implicated in organ development, the role of Fat2 in neural development remains poorly understood. Here, we investigated the function of Fat2 in zebrafish, focusing on its involvement in the development of cerebellar granule cells. Granule cells in the rostromedial cerebellum project their axons, known as parallel fibers, to Purkinje cell dendrites. In contrast, granule cells in the caudolateral cerebellum project their axons to Purkinje cells and further extend them caudally to innervate crest cells, Purkinje‐like neurons located in the dorsal hindbrain region called the medio‐octaval lateralis. We found that in fat2 mutants, axons of caudolateral cerebellar granule cells projecting to crest cells exhibit abnormal branching and frequently overshoot their targets. These results indicate that Fat2 is required for proper axon formation in at least a subset of cerebellar granule cells.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

The paper links to its data, not to its authors' code: see the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none, so it has no map.

Data

Datasets cited

Data Availability

All data supporting the findings of this study are publicly available in the Zenodo repository (https://doi.org/10.5281/zenodo.18480978), including the datasets underlying the analyses and results.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Publisher: — → Wiley

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 7 MeSH terms, 4 funders, 39 references.

Cite

This paper

Wang, J. C., Takeuchi, M., Dohaku, R., Kim, S., Solnica‐Krezel, L., Shimizu, T., & Hibi, M. (2026). Atypical Cadherin Fat2 is Involved in Axogenesis of Cerebellar Granule Cells in Zebrafish. Development, growth & differentiation, 68(4-5), e70060. https://doi.org/10.1111/dgd.70060

BibTeX

@article{wang2026atypical,
author = {Wang, Jui Chun and Takeuchi, Miki and Dohaku, Ryuji and Kim, Seok‐Hyung and Solnica‐Krezel, Lilianna and Shimizu, Takashi and Hibi, Masahiko},
title = {{Atypical Cadherin Fat2 is Involved in Axogenesis of Cerebellar Granule Cells in Zebrafish}},
journal = {Development, growth \& differentiation},
year = {2026},
month = may,
volume = {68},
number = {4-5},
pages = {e70060},
publisher = {Wiley},
issn = {0012-1592},
doi = {10.1111/dgd.70060},
url = {https://doi.org/10.1111/dgd.70060},
pmid = {42383708},
pmcid = {PMC13249537}
}

RIS

TY - JOUR
AU - Wang, Jui Chun
AU - Takeuchi, Miki
AU - Dohaku, Ryuji
AU - Kim, Seok‐Hyung
AU - Solnica‐Krezel, Lilianna
AU - Shimizu, Takashi
AU - Hibi, Masahiko
TI - Atypical Cadherin Fat2 is Involved in Axogenesis of Cerebellar Granule Cells in Zebrafish
T2 - Development, growth & differentiation
J2 - Dev Growth Differ
PY - 2026
DA - 2026/05/01
VL - 68
IS - 4-5
SP - e70060
SN - 0012-1592
PB - Wiley
DO - 10.1111/dgd.70060
UR - https://doi.org/10.1111/dgd.70060
LA - en
ER -

CSL-JSON

{
"id": "10.1111/dgd.70060",
"type": "article-journal",
"title": "Atypical Cadherin Fat2 is Involved in Axogenesis of Cerebellar Granule Cells in Zebrafish",
"container-title": "Development, growth & differentiation",
"author": [
{
"family": "Wang",
"given": "Jui Chun"
},
{
"family": "Takeuchi",
"given": "Miki"
},
{
"family": "Dohaku",
"given": "Ryuji"
},
{
"family": "Kim",
"given": "Seok‐Hyung"
},
{
"family": "Solnica‐Krezel",
"given": "Lilianna"
},
{
"family": "Shimizu",
"given": "Takashi"
},
{
"family": "Hibi",
"given": "Masahiko"
}
],
"container-title-short": "Dev Growth Differ",
"volume": "68",
"issue": "4-5",
"page": "e70060",
"DOI": "10.1111/dgd.70060",
"PMID": "42383708",
"PMCID": "PMC13249537",
"ISSN": "0012-1592",
"publisher": "Wiley",
"URL": "https://doi.org/10.1111/dgd.70060",
"language": "en",
"issued": {
"date-parts": [
[
2026,
5,
1
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1126/sciadv.aeb5860 [code]
The cerebellum implements structured representation of valence to support adaptive behavior control.
Journal: Science advances
In common: zebrafish, 5 references, 2 authors
[2] doi:10.7554/elife.100880 [code]
An applicable and efficient retrograde monosynaptic circuit mapping tool for larval zebrafish.
Journal: eLife
In common: zebrafish, 4 references
[3] doi:10.1186/s40246-026-00956-5
Rare variants in FAT3 as possible contributors to non-syndromic orofacial cleft risk.
Journal: Human genomics
In common: cellular / molecular, 4 references
[4] doi:10.1371/journal.pgen.1012171
Canalization of neural dynamics by δ-protocadherins in the developing zebrafish optic tectum.
Journal: PLoS genetics
In common: zebrafish, 1 reference
[5] doi:10.1038/s41467-026-77377-4 [code]
Ternary Neurexin-T178-PTPR complexes represent a pre-synaptic core-module of neuronal synapse organization.
Journal: Nature communications
In common: cellular / molecular, 1 reference
[6] doi:10.1186/s12974-026-03885-1 [code]
Shared transcriptomic signatures in perilesional and contralesional cortex after ischemic stroke.
Journal: Journal of neuroinflammation
In common: cellular / molecular, 1 reference
[7] doi:10.1038/s41467-026-75193-4 [code]
Multi-ancestry gene expression models amplify transcriptome-wide association study discovery and validation.
Journal: Nature communications
In common: cellular / molecular, 1 reference
[8] doi:10.7554/elife.103427
<i>Mettl5</i> coordinates protein production and degradation of PERIOD to regulate sleep in <i>Drosophila</i>.
Journal: eLife
In common: cellular / molecular, 1 reference
[9] doi:10.1016/j.isci.2026.116975
Loss of YY1 in Purkinje cells triggers cerebellar ataxia via Wnt10b-mediated impairment of dendrite development.
Journal: iScience
In common: cellular / molecular, 1 reference
[10] doi:10.1016/j.isci.2026.116299
Genetic dissection of the role of <i>Piga</i> and <i>Pgap2</i> in the embryonic mouse brain.
Journal: iScience
In common: 1 reference

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.