Investigating the Contribution of the Imprinted Gene Asb4 to Parental Care.
Overview
- Centre for Neuropsychiatric Genetics and Genomics, Neuroscience and Mental Health Innovation Institute, School of Medicine Cardiff University Cardiff UK
- School of Biosciences Cardiff University Cardiff UK
Abstract
Genomic imprinting is a form of epigenetic regulation that leads to expression from one parental allele only and, in animals, is unique to mammals. Imprinted gene expression is predominant in the brain and their roles in neural processes are becoming more appreciated. Recent analyses have indicated an enrichment of imprinted gene expression in the ‘parental hub’ circuitry. Specifically, imprinted genes were over‐represented in the transcriptomic profile of galanin positive (Gal+) neurons in the medial preoptic area (MPOA) of the hypothalamus. One of those imprinted genes showing enriched expression in Gal+ neurons was the maternally expressed Asb4. Here, we propose that Asb4 supports normal activation of MPOA Gal+ neurons required for parental care. We aim to demonstrate abnormal parental behaviours—such as decreased pup retrieval and impaired nest building—and activity of MPOA Gal+ neurons in brain‐specific maternal Asb4 knockout mice and hypothesis knockout animals will demonstrate a deficient behavioural phenotype in one or more parental behavioural characteristics.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
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Data Availability Statement
All raw and analysed data files will be made available on our OSF repository (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 3, 28 September 2026
- Publisher: n/a → Wiley
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 4 authors, 7 keywords, 9 MeSH terms, 2 funders, 18 references.
Cite
This paper
Jones, R., Higgs, M. J., John, R. M., & Isles, A. R. (2026). Investigating the Contribution of the Imprinted Gene Asb4 to Parental Care. The European journal of neuroscience, 64(5), e70655. https://
BibTeX
@article{jones2026invest
author = {Jones, Rachel‐Ann and Higgs, Matthew J. and John, Rosalind M. and Isles, Anthony R.},
title = {{Investigating the Contribution of the Imprinted Gene Asb4 to Parental Care}},
journal = {The European journal of neuroscience},
year = {2026},
month = sep,
volume = {64},
number = {5},
pages = {e70655},
publisher = {Wiley},
issn = {0953-816X},
doi = {10.1111/
url = {https://
pmid = {42706685},
pmcid = {PMC13550800}
}
RIS
TY - JOUR
AU - Jones, Rachel‐Ann
AU - Higgs, Matthew J.
AU - John, Rosalind M.
AU - Isles, Anthony R.
TI - Investigating the Contribution of the Imprinted Gene Asb4 to Parental Care
T2 - The European journal of neuroscience
J2 - Eur J Neurosci
PY - 2026
DA - 2026/
VL - 64
IS - 5
SP - e70655
SN - 0953-816X
PB - Wiley
DO - 10.1111/
UR - https://
LA - en
ER -
CSL-JSON
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"author": [
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"family": "Jones",
"given": "Rachel‐Ann"
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"family": "John",
"given": "Rosalind M."
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"family": "Isles",
"given": "Anthony R."
}
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"volume": "64",
"issue": "5",
"page": "e70655",
"DOI": "10.1111/
"PMID": "42706685",
"PMCID": "PMC13550800",
"ISSN": "0953-816X",
"publisher": "Wiley",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
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2026,
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}
}
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