Flexible integration of natural stimuli by auditory cortical neurons.
The 1 match
- [1] § Materials and Methods › Neuron model › Stimulus encoding ↔ models.py, lines 9–20 · score 0.59 · leaky integrate, fire model, gammatone, noise, sound
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Overview
Abstract
Neurons have rich input-output functions for processing and combining their inputs. Although many experiments characterize these functions by directly activating synaptic inputs on dendrites in vitro, the integration of spatiotemporal inputs representing real-world stimuli is less well studied. Using ethologically relevant stimuli, we study neuronal integration in relation to Boolean AND and OR operations thought to be important for pattern recognition. We recorded single-unit responses in the mouse auditory cortex to pairs of ultrasonic mouse vocalization (USV) syllables. We observed a range of integration responses, spanning the sublinear to supralinear regimes, with many responses resembling the MAX-like function, an instantiation of the OR operation. Integration was more MAX-like for strongly activating features, and more AND-like for spectrally distinct inputs. Importantly, single neurons could implement more than one integration function, in contrast to artificial networks which typically fix activation functions across all units and inputs. To understand the mechanism underlying the flexibility and heterogeneity in neuronal integration, we modelled how dendritic properties could influence the integration of inputs with complex spectrotemporal structure. Our results link nonlinear integration in dendrites to single-neuron computations for pattern recognition.
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kozlovlabcode/flex_integration
3af7c38f1c8a682454d4ad210682c122bc15d5d5, 6 February 2024Availability: 1 check, the latest on 29 September 2026: the link answers
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Cite
This paper
Ang, G. W. Y., Clopath, C., & Kozlov, A. S. (2026). Flexible integration of natural stimuli by auditory cortical neurons. Journal of neurophysiology, 135(5), 1385-1397. https://
BibTeX
@article{ang2026flexible
author = {Ang, Grace Wan Yu and Clopath, Claudia and Kozlov, Andriy S.},
title = {{Flexible integration of natural stimuli by auditory cortical neurons}},
journal = {Journal of neurophysiology},
year = {2026},
month = apr,
volume = {135},
number = {5},
pages = {1385--1397},
publisher = {American Physiological Society},
issn = {0022-3077},
doi = {10.1152/
url = {https://
pmid = {42013083},
pmcid = {PMC7619095}
}
RIS
TY - JOUR
AU - Ang, Grace Wan Yu
AU - Clopath, Claudia
AU - Kozlov, Andriy S.
TI - Flexible integration of natural stimuli by auditory cortical neurons
T2 - Journal of neurophysiology
J2 - J Neurophysiol
PY - 2026
DA - 2026/
VL - 135
IS - 5
SP - 1385
EP - 1397
SN - 0022-3077
PB - American Physiological Society
DO - 10.1152/
UR - https://
LA - en
ER -
CSL-JSON
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