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A sensorimotor instability drives a locomotor transition during fish development.

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Paper

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The authors' code

Text · 86 lines · 2.9 KB · CC-BY-4.0

  1. This Zenodo repository contains the data and code associated with the
  2. paper:
  4. "A sensorimotor instability drives a locomotor transition during fish development"
  6. The repository is organized in a modular way, reflecting the different
  7. experimental and computational components of the study. Each module is
  8. self-contained and documented by its own README file.
  10. Folder structure:
  11. =================
  13. Tracking_camera/
  14. Code and documentation related to the online tracking setup used for
  15. freely swimming fish.
  17. This module includes:
  18. - `code/`
  19. Acquisition and control code for the tracking camera.
  21. - `hardware/`
  22. Hardware-specific documentation detailing component configurations
  23. and experimental setup.
  25. - `yolo/`
  26. AI-based object detection (YOLO) used for real-time fish tracking.
  28. - `data/`
  29. Representative examples of raw data produced by the tracking system.
  31. - `postprocessing/`
  32. Tracking of fish posture from raw video recordings.
  33. ----------------
  35. Data_processing/
  36. Pipeline for converting segmented swimming postures of *Danionella* into
  37. unified, analysis-ready datasets. The output consists of standardized
  38. `.h5` files combining data across individual fish and developmental stages,
  39. used for all downstream analyses in the study.
  40. ----------------
  42. Analysis_transition/
  43. Analysis pipeline underlying the results presented in the paper.
  45. This module includes:
  46. - `input_data/`
  47. Analysis-ready data for all fish, generated by the
  48. `Data_processing/` pipeline.
  50. - `data/`
  51. Cleaned and derived datasets produced during downstream analysis
  52. (e.g. on/off binarization, onset of movements, intermediate results).
  54. - `code/`
  55. Analysis code used in the paper, organized into thematic subfolders.
  56. Each subfolder contains notebooks that reproduce the figures of the paper.
  57. Figures generated by these notebooks are saved in the corresponding
  58. `media/` folders.
  59. ----------------
  61. CFD_simulations/
  62. Computational fluid dynamics (CFD) simulations used to quantify
  63. swimming efficiency and energetic cost across body sizes and
  64. swimming modes.
  66. This module includes:
  67. - Simulation input and output data
  68. - Analysis code for extracting efficiency and cost metrics
  70. =================
  71. GENERAL NOTES:
  72. =================
  73. - For questions or additional information, please refer to the individual
  74. `README` files within each module.
  76. - The modular organization is designed to facilitate selective access, allowing
  77. users to download only the components of the study relevant to their interests.
  79. - Only representative example datasets are included when full datasets are too
  80. large to be hosted here.
  82. - Code is provided to ensure transparency and reproducibility of the published
  83. results.
  85. - This repository is intended as an **archival, citable snapshot** associated
  86. with the paper, rather than a continuously maintained software project.

README.txt, under CC-BY-4.0 · at the source

Overview

Authors: Monica Coraggioso1,2, Leonardo Demarchi1,2, Robert Wong3,4, Vito Dichio5, Chloé Chaumeton6, Thomas Panier1,2, Ghislaine Morvan-Dubois1,2, Geoffrey J Goodhill4, Volker Bormuth1,2, Georges Debrégeas1,2
ORCID iDs: Monica Coraggioso, Leonardo Demarchi, Robert Wong, Vito Dichio, Chloé Chaumeton, Thomas Panier, Ghislaine Morvan-Dubois, Geoffrey J Goodhill, Volker Bormuth, Georges Debrégeas
  1. Sorbonne Université, CNRS, Laboratoire Jean Perrin (LJP), F-75005 Paris, France
  2. Sorbonne Université, CNRS, Inserm, Institut de Biologie Paris-Seine (IBPS), F-75005 Paris, France
  3. Department of Electrical and Systems Engineering, Washington University in St. Louis, St. Louis, MO, USA
  4. Departments of Developmental Biology and Neuroscience, Washington University School of Medicine, St. Louis, MO, USA
  5. Laboratoire de Physique de l’ENS, PSL University and CNRS-UMR 8023, Paris, France
  6. Sorbonne Université, Institut de Biologie Paris-Seine, Paris, France
Institutions: Centre National de la Recherche Scientifique (France); Sorbonne Université (France); Laboratoire Jean Perrin (France); Institut de Biologie Paris-Seine (France); Washington University in St. Louis (United States); Université Paris Sciences et Lettres (France); École Normale Supérieure - PSL (France); Laboratoire de Physique de l'Ecole Normale Supérieure (France); Inserm (France)
Journal: Science advances, volume 12, issue 17, article eaec6922
Dates: received 29 September 2025; accepted 20 March 2026; published online 22 April 2026; in print April 2026
Type: Research article · Language: English
License: CC BY-NC
Identifiers: DOI 10.1126/sciadv.aec6922 · PMID 42018621 · PMCID PMC13101879 · OpenAlex W4415092531
Open access: gold, a free copy (OpenAlex)
Preprint: doi:10.1101/2025.10.10.681567
Status: code verified
Categories: other (organism)
Methods: Spectral & time-frequency, Preprocessing, Statistics
MeSH: Feedback, Sensory*, Fishes*, Locomotion*, Swimming*, Animals (* major topic)
Topic: Robotic Locomotion and Control (Biomedical Engineering, Engineering), according to OpenAlex
Funding: Association Neurofibromatoses et Recklinghause (ANR-21-CE16-0037); The European Union’s Horizon 2020 research and innovation programme under the Marie Sk lodowska-Curie grant agreement (860949)
Citations: cited by 1 paper (Europe PMC); 54 references in the paper

Abstract

Animals rely on movement to survive—to explore their environment, find food and mates, and avoid danger. During development, changes in body shape, muscle strength, and physiological needs drive the continuous adjustment of locomotor patterns. How these changes are orchestrated in a flexible and adaptive manner remains unknown. We explore this question in Danionella cerebrum, a miniature freshwater fish that is emerging as an important vertebrate model in systems neuroscience. We identify a clear transition in locomotion, from continuous to burst-and-coast swimming occurring around 3 weeks of age. We demonstrate that this transition is an energy-saving strategy and that it reflects an instability in the sensorimotor process governing speed regulation. Rather than a preprogrammed developmental switch, it is therefore directly tied to the animal swimming strength. We confirmed this finding by manipulating sensory feedback to induce a similar transition at fixed developmental stages. Together, our results illustrate a dynamic interplay between body, brain, and environment during development, offering insights into the principles governing adaptive locomotion.

Reproduced under the paper's license (CC BY-NC), from the paper cited above.

Repository

Its files are read in the Code ↔ Paper reader above.

Zenodo 17650136

License: CC-BY-4.0
State: the link answers, verified on 29 September 2026
Evidence: files inventoried
Size: 5 files
Software Heritage: not checked
Found in: “Data, code, and materials availability:”
Holds: README
Not found: license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 29 September 2026: the link answers (HTTP 200)
  • 29 September 2026: the link answers (HTTP 200)
1 file
At the source: doi.org/10.5281/zenodo.17650136

The paper's code and data availability statement is in the Data section.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 1 repository of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 0 scripts, each with its path and the digest of its content;
  • no match between paragraphs and code yet;
  • neither the text of the paper nor the code itself.

Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Data, code, and materials availability

Data and code are available on Zenodo: https://doi.org/10.5281/zenodo.17650136. All data and code needed to evaluate and reproduce the results in the paper are present in the paper and/or the Supplementary Materials. These experiments did not generate any new materials.

Reproduced under the paper's license (CC BY-NC), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 5 MeSH terms, 2 funders, 39 references.

Cite

This paper

Coraggioso, M., Demarchi, L., Wong, R., Dichio, V., Chaumeton, C., Panier, T., Morvan-Dubois, G., Goodhill, G. J., Bormuth, V., & Debrégeas, G. (2026). A sensorimotor instability drives a locomotor transition during fish development. Science advances, 12(17), eaec6922. https://doi.org/10.1126/sciadv.aec6922

BibTeX

@article{coraggioso2026sensorimotor,
author = {Coraggioso, Monica and Demarchi, Leonardo and Wong, Robert and Dichio, Vito and Chaumeton, Chloé and Panier, Thomas and Morvan-Dubois, Ghislaine and Goodhill, Geoffrey J and Bormuth, Volker and Debrégeas, Georges},
title = {{A sensorimotor instability drives a locomotor transition during fish development}},
journal = {Science advances},
year = {2026},
month = apr,
volume = {12},
number = {17},
pages = {eaec6922},
publisher = {American Association for the Advancement of Science},
issn = {2375-2548},
doi = {10.1126/sciadv.aec6922},
url = {https://doi.org/10.1126/sciadv.aec6922},
pmid = {42018621},
pmcid = {PMC13101879}
}

RIS

TY - JOUR
AU - Coraggioso, Monica
AU - Demarchi, Leonardo
AU - Wong, Robert
AU - Dichio, Vito
AU - Chaumeton, Chloé
AU - Panier, Thomas
AU - Morvan-Dubois, Ghislaine
AU - Goodhill, Geoffrey J
AU - Bormuth, Volker
AU - Debrégeas, Georges
TI - A sensorimotor instability drives a locomotor transition during fish development
T2 - Science advances
J2 - Sci Adv
PY - 2026
DA - 2026/04/22
VL - 12
IS - 17
SP - eaec6922
SN - 2375-2548
PB - American Association for the Advancement of Science
DO - 10.1126/sciadv.aec6922
UR - https://doi.org/10.1126/sciadv.aec6922
LA - en
ER -

CSL-JSON

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