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Blocking RAN translation without altering repeat RNAs rescues <i>C9ORF72</i>-related ALS and FTD phenotypes.

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Code

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wainger-lab/STING

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State: the link is dead

waingerlab/Jiang_etal

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State: the link answers
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Tools found in the code: Image Processing Toolbox

Overview

Authors: Xin Jiang, Laure Schaeffer, Divya Patni, Tommaso Russo, Chao-Zong Lee, Corey Aguilar, Christine Marques, Karen Jansen-West, Marian Hruska-Plochan, Ananya Ray-Soni, Su Min Lim, Aaron Held, Mei Yue, Paula Castellanos Otero, Sandeep Aryal, Hortense D A M Beaussant, Himanish Basu, Hiro Takakuwa, Lillian M Daughrity, Nandini Ramesh
and 26 other authorsPaulo Da Costa, Ana Rita A A Quadros, Matthew Nolan, Charles Jourdan F Reyes, Hayden Wheeler, Laura C Moran, Grant Griesman, Benjamin Wymann, Bianca A Trombetta, Emma Sofia Lopez-De-Silanes, Michael Canori, Gopinath Krishnan, Yasmim Vieira Souza Da Silva, Gilbert Eriani, Mark W Albers, Steven E Arnold, Yuyu Song, Ankur Jain, Isaac M Chiu, Yong-Jie Zhang, Fen-Biao Gao, Brian J Wainger, Magdalini Polymenidou, Leonard Petrucelli, Franck Martin, Clotilde Lagier-Tourenne
Journal: Science (New York, N.Y.)
Published: 5 February 2026
Type: Research article
Status: code verified (how the code is found and verified)
DOI: 10.1126/science.adv2600
License: CC BY
Institutions: Broad Institute (United States), Harvard University (United States), Massachusetts General Hospital (United States), Centre National de la Recherche Scientifique (France), Architecture et Réactivité de l'arN (France), Institut de Biologie Moléculaire et Cellulaire (France), Université de Strasbourg (France), IRCCS Ospedale San Raffaele (Italy), IRCCS San Raffaele Roma (Italy), Mayo Clinic in Florida (United States), University of Zurich (Switzerland), Whitehead Institute for Biomedical Research (United States), University of Massachusetts Chan Medical School (United States), Marine Biological Laboratory (United States), Massachusetts Institute of Technology (United States)
Categories: human (organism), mouse (organism), other condition (population), Alzheimer's / dementia (population), cellular / molecular (subfield)

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