OSCR

Nerves Stimulate Cross-talk Between Gastric Cancer and Group 3 Innate Lymphoid Cells to Enhance Immunosuppression.

Overview

  1. Department of Laboratory Medicine, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China
  2. Key Laboratory of Laboratory Medical Diagnostics, Chinese Ministry of Education, Chongqing Medical University, Chongqing, China
  3. Department of Surgery and Cancer, Imperial College London, London, United Kingdom
Journal: Cancer research, volume 86, issue 8, pages 1968-1986
Dates: received 16 July 2025; accepted 13 January 2026; published online 14 January 2026; in print 15 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1158/0008-5472.can-25-3092 · PMID 41534088 · PMCID PMC13080324 · OpenAlex W7124163084
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: human (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions
MeSH: Immunity, Innate*, Lymphocytes*, Stomach Neoplasms*, Vagus Nerve*, Acetylcholine, Animals, B7-H1 Antigen, Cell Line, Tumor, Humans, Immune Tolerance, Tumor Microenvironment (* major topic)
Journal subjects: Gastrointestinal Cancers, Stomach Cancer, Immunology, Immunotherapy, Checkpoint Blockade, Combination Immunotherapy, Tumor Microenvironment, Cytokines and the Microenvironment, Immune Cells and the Microenvironment, Cancer Immunology
Topic: IL-33, ST2, and ILC Pathways (Immunology, Immunology and Microbiology), according to OpenAlex
Funding: National Natural Science Foundation of China (National Science Foundation of China) (82303321); China Postdoctoral Science Foundation (2023T160774); Chongqing Postdoctoral Science Foundation (Postdoctoral Science Foundation of Chongqing) (2022CQBSHTB2032); Chongqing Medical Young Talent Project (YXQN202443); General Program of Chongqing Natural Science Foundation (CSTB2025NS CQ–, GPX1130); Chongqing Science and Technology Innovation Leading Talent Support Program (CSTC2024 YCJH–, BGZXM0070); Natural Science Foundation of Chongqing China (CSTB2023 NSCQ–, MSX0125)
Citations: cited by 9 papers (Europe PMC); 42 references in the paper
Research resources: FITC anti-human CD14 RRID:AB_10597597, FITC anti-human CD19 RRID:AB_10669461, PE anti-human CD127 RRID:AB_10720185, APC anti-mouse CD206 RRID:AB_10896057, Brilliant Violet 421 anti-mouse CD274 RRID:AB_10897097, Brilliant Violet 421 anti-mouse CD45 RRID:AB_10899570, CD90.2 RRID:AB_1107682, anti-RORC RRID:AB_11115140, PE anti-mouse RORγt RRID:AB_11153137, PE anti-mouse Ly6G RRID:AB_1186104, IL22 Monoclonal Antibody RRID:AB_2016695, FITC anti-human CD3 RRID:AB_2043831, anti-AKT RRID:AB_2224574, anti–phospho-AKT RRID:AB_2315049, anti–phospho-STAT3 RRID:AB_2491009, Brilliant Violet 605 anti-mouse CD127 RRID:AB_2562114, Brilliant Violet 421 anti-human CD294 RRID:AB_2562468, APC anti-mouse CD8b RRID:AB_2562774, PerCP/Cyanine5.5 anti-mouse IL22 RRID:AB_2563373, AF647 anti-STAT3 phospho RRID:AB_2572085, FITC anti-mouse CD19 RRID:AB_2629812, anti-CD4 RRID:AB_2686917, PE/Dazzle 594 anti-mouse CD273 RRID:AB_2728124, AF700 anti-mouse FOXP3 RRID:AB_2750492, anti–PD-L1 RRID:AB_2756526, anti-IL22RA1 RRID:AB_2758331, muscarinic 3 RRID:AB_2763456, anti-vesicular ACh transporter RRID:AB_2763508, The antibodies used include anti-FOXP3 RRID:AB_2797979, anti-CD19 RRID:AB_2800152, RRID:AB_2819164, RRID:AB_2827665, 000) and goat anti-rabbit IgG RRID:AB_2827666, FITC anti-mouse F4/80 RRID:AB_2876535, PE anti-mouse CD45 RRID:AB_2876536, anti-GAPDH RRID:AB_2885058, anti-CD8 RRID:AB_2890649, anti-CD206 RRID:AB_2892682, anti-NK1.1 RRID:AB_2892989, anti-Ly6G RRID:AB_2923218, BV650 anti-human CD45 RRID:AB_2925684, anti–HIF-1 alpha RRID:AB_302883, anti-STAT3 RRID:AB_3069762, iFluor 647 anti-Ki67 RRID:AB_3072100, FITC anti-mouse CD3 RRID:AB_312660, APC anti-mouse CD4 RRID:AB_312696, FITC anti-mouse NK1.1 RRID:AB_313392, PE anti-mouse MHC-I RRID:AB_313614, FITC anti-mouse CD11c RRID:AB_313774, APC anti-human CD117 RRID:AB_314985, APC anti-mouse CD3 RRID:AB_3675272, anti–P-CK RRID:AB_3676255, PerCP-Cyanine5.5 anti–T-bet RRID:AB_953658, FITC anti-mouse CD25 RRID:AB_961210, SGC-7901 RRID:CVCL_0520, NCI-N87 RRID:CVCL_1603, MGC-803 RRID:CVCL_5334, MFC RRID:CVCL_5J4, GES-1 RRID:CVCL_EQ22, MNK3 RRID:CVCL_IZ72, RRID:SCR_002798, RRID:SCR_008520

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Code and data availability statement

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Read it in the paper: doi.org/10.1158/0008-5472.can-25-3092.

Versions

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Version 2, 28 September 2026

  • Publisher: n/a → American Association for Cancer Research

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 11 MeSH terms, 7 funders, 42 references, 62 RRIDs.

Cite

This paper

Liao, F., Tong, Y., Sun, H., Chen, S., Wen, S., Du, Y.-e., Jiang, L., Huang, T., Liu, M., Chen, W., & Yang, L. (2026). Nerves Stimulate Cross-talk Between Gastric Cancer and Group 3 Innate Lymphoid Cells to Enhance Immunosuppression. Cancer research, 86(8), 1968-1986. https://doi.org/10.1158/0008-5472.can-25-3092

BibTeX

@article{liao2026nerves,
author = {Liao, Fangli and Tong, Yanran and Sun, Hua and Chen, Sen and Wen, Siyang and Du, Yan-e and Jiang, Linshan and Huang, Tong and Liu, Manran and Chen, Weixian and Yang, Liping},
title = {{Nerves Stimulate Cross-talk Between Gastric Cancer and Group 3 Innate Lymphoid Cells to Enhance Immunosuppression}},
journal = {Cancer research},
year = {2026},
month = apr,
volume = {86},
number = {8},
pages = {1968--1986},
publisher = {American Association for Cancer Research},
issn = {0008-5472},
doi = {10.1158/0008-5472.can-25-3092},
url = {https://doi.org/10.1158/0008-5472.can-25-3092},
pmid = {41534088},
pmcid = {PMC13080324}
}

RIS

TY - JOUR
AU - Liao, Fangli
AU - Tong, Yanran
AU - Sun, Hua
AU - Chen, Sen
AU - Wen, Siyang
AU - Du, Yan-e
AU - Jiang, Linshan
AU - Huang, Tong
AU - Liu, Manran
AU - Chen, Weixian
AU - Yang, Liping
TI - Nerves Stimulate Cross-talk Between Gastric Cancer and Group 3 Innate Lymphoid Cells to Enhance Immunosuppression
T2 - Cancer research
J2 - Cancer Res
PY - 2026
DA - 2026/04/01
VL - 86
IS - 8
SP - 1968
EP - 1986
SN - 0008-5472
PB - American Association for Cancer Research
DO - 10.1158/0008-5472.can-25-3092
UR - https://doi.org/10.1158/0008-5472.can-25-3092
LA - en
ER -

CSL-JSON

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"type": "article-journal",
"title": "Nerves Stimulate Cross-talk Between Gastric Cancer and Group 3 Innate Lymphoid Cells to Enhance Immunosuppression",
"container-title": "Cancer research",
"author": [
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"family": "Liao",
"given": "Fangli"
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{
"family": "Tong",
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{
"family": "Sun",
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},
{
"family": "Chen",
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{
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{
"family": "Chen",
"given": "Weixian"
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"container-title-short": "Cancer Res",
"volume": "86",
"issue": "8",
"page": "1968-1986",
"DOI": "10.1158/0008-5472.can-25-3092",
"PMID": "41534088",
"PMCID": "PMC13080324",
"ISSN": "0008-5472",
"publisher": "American Association for Cancer Research",
"URL": "https://doi.org/10.1158/0008-5472.can-25-3092",
"language": "en",
"issued": {
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