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Clarifying and extending permutation tests on brain map correspondence through mixed-effects modeling.

Code ↔ Paper

2 matches between paragraphs of the paper and lines of its authors' code, computed by the harvester (lexical-v1). Click a colored paragraph or line to see its counterpart.

The 2 matches
  1. [1] § Brain Map Correspondence in HCP Data › Correspondence between subject-specific brain maps ↔ python-implementation/bootstrap_inference/utils.py, lines 84–122 · score 0.61 · confidence intervals, cross terms, interaction subject, CI, residuals, bootstrap
  2. [2] § Brain Map Correspondence in HCP Data › Correspondence between subject-specific brain maps ↔ python-implementation/bootstrap_inference/utils.py, lines 84–122 · score 0.58 · confidence intervals, cross term, interaction subject, residuals, bootstrap

Paper

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The authors' code

Python · 336 lines · 13 KB · no license · 2 matches

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It can be read at the source: python-implementation/bootstrap_inference/utils.py.

Overview

Authors: Qiaochu Wang1, Lingyi Peng2, Thomas E Nichols3, Xu Zou1, Yaotian Wang4, Jie He1, Yuexin Zhang1, Dana L Tudorascu2, Diego Szczupak5, Lauren Schaeffer5, Emily S Rothwell5, Laurel Dieckhaus5, Stacey J Sukoff Rizzo5, Gregory W Carter6, Afonso C Silva5, Tingting Zhang1
ORCID iDs: Qiaochu Wang, Thomas E Nichols, Xu Zou, Jie He, Yuexin Zhang, Diego Szczupak, Emily S Rothwell, Laurel Dieckhaus, Stacey J Sukoff Rizzo, Gregory W Carter, Afonso C Silva, Tingting Zhang
  1. Department of Statistics, University of Pittsburgh, Pittsburgh, PA, United States
  2. Department of Biostatistics and Health Data Science, University of Pittsburgh, Pittsburgh, PA, United States
  3. Oxford Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
  4. Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, United States
  5. Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, United States
  6. The Jackson Laboratory, Bar Harbor, ME, United States
Institutions: University of Pittsburgh (United States); University of Oxford (United Kingdom); Emory University (United States); Jackson Laboratory (United States)
Journal: Imaging neuroscience (Cambridge, Mass.), volume 4, article IMAG.a.1350
Dates: received 29 November 2025; accepted 30 July 2026; published online 8 September 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1162/imag.a.1350 · PMID 42719771 · PMCID PMC13556793 · OpenAlex W7202155274
Open access: diamond, a free copy (OpenAlex)
Status: code verified
Categories: structural MRI / diffusion (modality), human (organism), computational (subfield)
Methods: Connectivity, Statistics, fMRI & imaging, Preprocessing
Keywords: brain map correspondence, mixed-effects models, permutation tests, bootstrapping
MeSH: Brain*, Brain Mapping*, Image Processing, Computer-Assisted*, Computer Simulation, Humans, Magnetic Resonance Imaging (* major topic)
Topic: Functional Brain Connectivity Studies (Cognitive Neuroscience, Neuroscience), according to OpenAlex
Funding: NIA NIH HHS (U19 AG074866, P01 AG025204, R01 AG063752); NIMH NIH HHS (U54 MH091657); NIH HHS (S10 OD028483)
Citations: not cited yet (Europe PMC); 50 references in the paper
Research resources: RRID:SCR_022735

Abstract

Permutation-based methods such as the spin test, Brain Surrogate Maps with Autocorrelated Spatial Heterogeneity (BrainSMASH), and the simple permutation-based intermodal correspondence (SPICE) test are widely used to assess correspondence between brain maps while accounting for their spatial autocorrelation. However, these methods define and evaluate correspondence in fundamentally different ways, making their results difficult to compare or interpret jointly. We address these limitations by introducing a two-factor mixed-effects model that decomposes brain map variability into components arising from inter-subject variability and spatial variability across brain locations. This formulation provides a principled way to characterize distinct sources of variability in brain maps and to formally link each correspondence test to the specific component it targets. Within this framework, we further provide the analytical expressions of the null distributions of the spin test, BrainSMASH, and SPICE in terms of model parameters. This unified framework clarifies the fundamental distinctions among the permutation tests, reveals their implicit assumptions, and provides a principled way to compare and interpret their results. Beyond clarifying existing methods, the modeling framework naturally motivates a bootstrap-based method that enables simultaneous inference of multiple forms of correspondence arising from different components of brain map variability. Through extensive simulations and empirical analyses of both structural (cortical thickness vs. sulcal depth) and functional (language vs. motor contrast) brain maps, we demonstrate that the bootstrap-based method achieves well-calibrated type I error, substantially higher statistical power, and provides a robust and comprehensive characterization of different forms of brain map correspondence.

Reproduced under the paper's license (CC BY), from the paper cited above.

Repositories

Its files are read in the Code ↔ Paper reader above, with 2 matches between paragraphs and lines of code.

spin-test/spin-test

License: MIT
State: the link answers, verified on 26 September 2026
Evidence: files inventoried
Commit: d149e273f2dcfb3d1d3e86c4ec7293dd9e38e265, 25 August 2020
Languages: MATLAB (87)
Size: 120 files, 87 scripts
Software Heritage: archived
Found in: the text, “The Spin test”
Holds: README, license file, 1 notebook
Not found: CITATION.cff, environment file, tests, continuous integration, documentation
Tools: FreeSurfer (3 files)
Availability: 1 check, the latest on 26 September 2026: the link answers
  • 26 September 2026: the link answers
89 files
At the source: github.com/spin-test/spin-test

frantisekvasa/rotate_parcellation

License: MIT
State: the link answers, verified on 26 September 2026
Evidence: files inventoried
Commit: 65673ea7f47fca36b2982df669fc649b9a4bc5da, 29 June 2023
Languages: MATLAB (3), R (2)
Size: 9 files, 5 scripts
Software Heritage: archived
Found in: the text, “The Spin test”
Holds: README, license file
Not found: CITATION.cff, environment file, tests, continuous integration, documentation
Tools: FreeSurfer (1 file)
Availability: 1 check, the latest on 26 September 2026: the link answers
  • 26 September 2026: the link answers
7 files
At the source: github.com/frantisekvasa/rotate_parcellation

qcwang77/brainmap-bootstrap

License: none: the authors keep all their rights
State: the link answers, verified on 26 September 2026
Evidence: files inventoried
Commit: 3927737d19b697174503e4427872c03a2d82b444, 27 May 2026
Languages: Python (6)
Size: 16 files, 6 scripts
Software Heritage: not archived
Found in: “Data and Code Availability”
Holds: README, environment (python-implementation/requirements.txt)
Not found: license file, CITATION.cff, tests, continuous integration, documentation
Tools: NumPy (5 files)
Availability: 1 check, the latest on 26 September 2026: the link answers
  • 26 September 2026: the link answers
7 files, not copied: shown from their source

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At the source: github.com/qcwang77/brainmap-bootstrap

The paper's code and data availability statement is in the Data section.

Tracing map

Proposed by the machine: these links were found in the paper and verified at the source, without human review. The map will receive a Zenodo DOI once one of the paper's authors has validated it with their ORCID.

What the map holds:

  • 3 repositories of the authors' code, each at its verified commit, with its license and how the link was found in the paper;
  • 98 scripts, each with its path and the digest of its content;
  • 2 matches between paragraphs of the paper and lines of the code (method lexical-v1);
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Its JSON (tracing-map.json) is deposited on Zenodo with its DOI once the map is validated.

Data

No dataset and no data link were found in the paper.

Data and Code Availability

The open access HCP-S1200 data can be downloaded from the data management platform ConnectomeDB: https://db.humanconnectome.org upon signing up for an account. The code for the analyses presented in this paper is included as a compressed file in the supplementary materials and is also available on GitHub (https://github.com/qcwang77/brainmap-bootstrap).

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, pages, dates, 16 authors, 4 keywords, 6 MeSH terms, 3 funders, 49 references, 1 RRID.

Cite

This paper

Wang, Q., Peng, L., Nichols, T. E., Zou, X., Wang, Y., He, J., Zhang, Y., Tudorascu, D. L., Szczupak, D., Schaeffer, L., Rothwell, E. S., Dieckhaus, L., Sukoff Rizzo, S. J., Carter, G. W., Silva, A. C., & Zhang, T. (2026). Clarifying and extending permutation tests on brain map correspondence through mixed-effects modeling. Imaging neuroscience (Cambridge, Mass.), 4, IMAG.a.1350. https://doi.org/10.1162/imag.a.1350

BibTeX

@article{wang2026clarifying,
author = {Wang, Qiaochu and Peng, Lingyi and Nichols, Thomas E and Zou, Xu and Wang, Yaotian and He, Jie and Zhang, Yuexin and Tudorascu, Dana L and Szczupak, Diego and Schaeffer, Lauren and Rothwell, Emily S and Dieckhaus, Laurel and Sukoff Rizzo, Stacey J and Carter, Gregory W and Silva, Afonso C and Zhang, Tingting},
title = {{Clarifying and extending permutation tests on brain map correspondence through mixed-effects modeling}},
journal = {Imaging neuroscience (Cambridge, Mass.)},
year = {2026},
month = sep,
volume = {4},
pages = {IMAG.a.1350},
publisher = {MIT Press},
issn = {2837-6056},
doi = {10.1162/imag.a.1350},
url = {https://doi.org/10.1162/imag.a.1350},
pmid = {42719771},
pmcid = {PMC13556793}
}

RIS

TY - JOUR
AU - Wang, Qiaochu
AU - Peng, Lingyi
AU - Nichols, Thomas E
AU - Zou, Xu
AU - Wang, Yaotian
AU - He, Jie
AU - Zhang, Yuexin
AU - Tudorascu, Dana L
AU - Szczupak, Diego
AU - Schaeffer, Lauren
AU - Rothwell, Emily S
AU - Dieckhaus, Laurel
AU - Sukoff Rizzo, Stacey J
AU - Carter, Gregory W
AU - Silva, Afonso C
AU - Zhang, Tingting
TI - Clarifying and extending permutation tests on brain map correspondence through mixed-effects modeling
T2 - Imaging neuroscience (Cambridge, Mass.)
J2 - Imaging Neurosci (Camb)
PY - 2026
DA - 2026/09/08
VL - 4
SP - IMAG.a.1350
SN - 2837-6056
PB - MIT Press
DO - 10.1162/imag.a.1350
UR - https://doi.org/10.1162/imag.a.1350
LA - en
ER -

CSL-JSON

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The tracing map gets a citation of its own once an author has validated it and it has a DOI.

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