OSCR

Sexual Dimorphism Is Associated With Corneal Nerve and Epithelial Alterations and Tear-Film Defects in Pax6 Haploinsufficiency Mouse Model.

Overview

Authors: Marjolaine Willems1,2,3, Mélissa Girard1, Nadège Feret1, Dylan Touchet1, Jérôme Vialaret1,4, Jana Kindermans1,4, Laura Fichter1,4, Christophe Hirtz1,4, Dominique Bremond-Gignac5, Vincent Daien1,3,6,7, Cécile Delettre1, Marie Pequignot1, Frederic Michon1,6
  1. Institute for Neurosciences of Montpellier, University of Montpellier, INSERM, Montpellier, France
  2. Department of Clinical Genetics, Arnaud de Villeneuve Hospital, University Hospital of Montpellier, Montpellier, France
  3. OPHTARA Rare Disease Competence Center, University Hospital of Montpellier, Montpellier, France
  4. IRMB-PPC, University of Montpellier, University Hospital of Montpellier, INSERM CNRS, Montpellier, France
  5. Department of Ophthalmology, University Hospital Necker Enfants Malades, APHP, Paris, INSERM UMRS 1138, T17, Centre de Reference Maladies Rares OPHTARA Rare Disease Reference Center, Paris, France
  6. Department of Ophthalmology, Gui de Chauliac Hospital, University Hospital of Montpellier, Montpellier, France
  7. The Save Sight Institute, Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia
Journal: Investigative ophthalmology & visual science, volume 67, issue 5, article 39
Dates: received 19 November 2025; accepted 23 April 2026; published online 18 May 2026; in print May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1167/iovs.67.5.39 · PMID 42149034 · PMCID PMC13193210 · OpenAlex W7161594700
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), mouse (organism), cellular / molecular (subfield)
Methods: Statistics, Physiology & signal measures
Keywords: PAX6, aniridia-associated keratopathy (AAK), wound healing, sexual dimorphism
MeSH: Cornea*, Epithelium, Corneal*, Haploinsufficiency*, Ophthalmic Nerve*, PAX6 Transcription Factor*, Sex Characteristics*, Tears*, Animals, Disease Models, Animal, Female, Male, Mice, Mice, Inbred C57BL (* major topic)
Topic: Ocular Surface and Contact Lens (Public Health, Environmental and Occupational Health, Medicine), according to OpenAlex
Citations: not cited yet (Europe PMC); 77 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

Tracing map

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1167/iovs.67.5.39.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 13 authors, 4 keywords, 13 MeSH terms, 72 references.

Cite

This paper

Willems, M., Girard, M., Feret, N., Touchet, D., Vialaret, J., Kindermans, J., Fichter, L., Hirtz, C., Bremond-Gignac, D., Daien, V., Delettre, C., Pequignot, M., & Michon, F. (2026). Sexual Dimorphism Is Associated With Corneal Nerve and Epithelial Alterations and Tear-Film Defects in Pax6 Haploinsufficiency Mouse Model. Investigative ophthalmology & visual science, 67(5), 39. https://doi.org/10.1167/iovs.67.5.39

BibTeX

@article{willems2026sexual,
author = {Willems, Marjolaine and Girard, Mélissa and Feret, Nadège and Touchet, Dylan and Vialaret, Jérôme and Kindermans, Jana and Fichter, Laura and Hirtz, Christophe and Bremond-Gignac, Dominique and Daien, Vincent and Delettre, Cécile and Pequignot, Marie and Michon, Frederic},
title = {{Sexual Dimorphism Is Associated With Corneal Nerve and Epithelial Alterations and Tear-Film Defects in Pax6 Haploinsufficiency Mouse Model}},
journal = {Investigative ophthalmology \& visual science},
year = {2026},
month = may,
volume = {67},
number = {5},
pages = {39},
publisher = {Association for Research in Vision and Ophthalmology},
issn = {0146-0404},
doi = {10.1167/iovs.67.5.39},
url = {https://doi.org/10.1167/iovs.67.5.39},
pmid = {42149034},
pmcid = {PMC13193210}
}

RIS

TY - JOUR
AU - Willems, Marjolaine
AU - Girard, Mélissa
AU - Feret, Nadège
AU - Touchet, Dylan
AU - Vialaret, Jérôme
AU - Kindermans, Jana
AU - Fichter, Laura
AU - Hirtz, Christophe
AU - Bremond-Gignac, Dominique
AU - Daien, Vincent
AU - Delettre, Cécile
AU - Pequignot, Marie
AU - Michon, Frederic
TI - Sexual Dimorphism Is Associated With Corneal Nerve and Epithelial Alterations and Tear-Film Defects in Pax6 Haploinsufficiency Mouse Model
T2 - Investigative ophthalmology & visual science
J2 - Invest Ophthalmol Vis Sci
PY - 2026
DA - 2026/05/01
VL - 67
IS - 5
SP - 39
SN - 0146-0404
PB - Association for Research in Vision and Ophthalmology
DO - 10.1167/iovs.67.5.39
UR - https://doi.org/10.1167/iovs.67.5.39
LA - en
ER -

CSL-JSON

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"id": "10.1167/iovs.67.5.39",
"type": "article-journal",
"title": "Sexual Dimorphism Is Associated With Corneal Nerve and Epithelial Alterations and Tear-Film Defects in Pax6 Haploinsufficiency Mouse Model",
"container-title": "Investigative ophthalmology & visual science",
"author": [
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{
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"given": "Jérôme"
},
{
"family": "Kindermans",
"given": "Jana"
},
{
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"given": "Laura"
},
{
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{
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{
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"container-title-short": "Invest Ophthalmol Vis Sci",
"volume": "67",
"issue": "5",
"page": "39",
"DOI": "10.1167/iovs.67.5.39",
"PMID": "42149034",
"PMCID": "PMC13193210",
"ISSN": "0146-0404",
"publisher": "Association for Research in Vision and Ophthalmology",
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"language": "en",
"issued": {
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}

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