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Lactate-activated astrocytes promote NSCLC brain metastasis through extracellular vesicle-mediated miR-8085/TRIM67/ELK1 signaling axis.

Overview

Authors: Haiqin Peng1, Guilong Tanzhu1, Wen Shi1, Gang Xiao1, Qian Zeng1, Liu Chen1, Xin Wan2, Di Jing1, Haibin Deng3,4, Thomas Michael Marti3,4, Jun Fu5,6, Rongrong Zhou1,7,8
ORCID iDs: Guilong Tanzhu
  1. Department of Oncology, Xiangya Hospital, Central South University,Changsha, 410008 China
  2. Department of Neurosurgery, Xiangya Hospital, Central South University,Changsha, 410008 China
  3. Department of General Thoracic Surgery, Inselspital, Bern University Hospital,Bern, Switzerland
  4. Department for BioMedical Research, University of Bern,Bern, Switzerland
  5. Clinical Research Center (CRC), Medical Pathology Center (MPC), Cancer Early Detection and Treatment Center (CEDTC) and Translational Medicine Research Center (TMRC), Chongqing University Three Gorges Hospital, Chongqing University,Wanzhou District, Chongqing, 404100 China
  6. CQU - Ferenc Krausz Nobel Laureate Scientific Workstation, Chongqing University Three Gorges Hospital & Academy for Advanced Interdisciplinary Technology,Chongqing, 404100 China
  7. Xiangya Lung Cancer Center, Xiangya Hospital, Central South University,Changsha, 410008 China
  8. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University,Changsha, 410008 Hunan Province People’s Republic of China
Institutions: Central South University (China); University Hospital of Bern (Switzerland); University of Bern (Switzerland); Chongqing University (China)
Journal: Cellular & molecular biology letters, volume 31, issue 1, article 138
Dates: received 25 June 2025; accepted 11 May 2026; published online 31 May 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s11658-026-00957-1 · PMID 42226139 · PMCID PMC13523199 · OpenAlex W7163022855
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions
Keywords: Brain metastasis, Astrocyte, Lactate, Extracellular vesicles, Tumor stemness, NSCLC
MeSH: Astrocytes*, Brain Neoplasms*, Carcinoma, Non-Small-Cell Lung*, Extracellular Vesicles*, Lactic Acid*, Lung Neoplasms*, MicroRNAs*, Tripartite Motif Proteins*, Ubiquitin-Protein Ligases*, Animals, Cell Line, Tumor, Gene Expression Regulation, Neoplastic, Humans, Monocarboxylate Transport Protein 1, Monocarboxylic Acid Transporters, Signal Transduction (* major topic)
Topic: Brain Metastases and Treatment (Pulmonary and Respiratory Medicine, Medicine), according to OpenAlex
Funding: Natural Science Foundation of Hunan (2022JJ30992)
Citations: cited by 2 papers (Europe PMC); 52 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

Datasets cited

Code and data availability statement

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Read it in the paper: doi.org/10.1186/s11658-026-00957-1.

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 6 keywords, 16 MeSH terms, 1 funder, 52 references.

Cite

This paper

Peng, H., Tanzhu, G., Shi, W., Xiao, G., Zeng, Q., Chen, L., Wan, X., Jing, D., Deng, H., Marti, T. M., Fu, J., & Zhou, R. (2026). Lactate-activated astrocytes promote NSCLC brain metastasis through extracellular vesicle-mediated miR-8085/TRIM67/ELK1 signaling axis. Cellular & molecular biology letters, 31(1), 138. https://doi.org/10.1186/s11658-026-00957-1

BibTeX

@article{peng2026lactate,
author = {Peng, Haiqin and Tanzhu, Guilong and Shi, Wen and Xiao, Gang and Zeng, Qian and Chen, Liu and Wan, Xin and Jing, Di and Deng, Haibin and Marti, Thomas Michael and Fu, Jun and Zhou, Rongrong},
title = {{Lactate-activated astrocytes promote NSCLC brain metastasis through extracellular vesicle-mediated miR-8085/TRIM67/ELK1 signaling axis}},
journal = {Cellular \& molecular biology letters},
year = {2026},
month = may,
volume = {31},
number = {1},
pages = {138},
publisher = {BMC},
issn = {1425-8153},
doi = {10.1186/s11658-026-00957-1},
url = {https://doi.org/10.1186/s11658-026-00957-1},
pmid = {42226139},
pmcid = {PMC13523199}
}

RIS

TY - JOUR
AU - Peng, Haiqin
AU - Tanzhu, Guilong
AU - Shi, Wen
AU - Xiao, Gang
AU - Zeng, Qian
AU - Chen, Liu
AU - Wan, Xin
AU - Jing, Di
AU - Deng, Haibin
AU - Marti, Thomas Michael
AU - Fu, Jun
AU - Zhou, Rongrong
TI - Lactate-activated astrocytes promote NSCLC brain metastasis through extracellular vesicle-mediated miR-8085/TRIM67/ELK1 signaling axis
T2 - Cellular & molecular biology letters
J2 - Cell Mol Biol Lett
PY - 2026
DA - 2026/05/31
VL - 31
IS - 1
SP - 138
SN - 1425-8153
PB - BMC
DO - 10.1186/s11658-026-00957-1
UR - https://doi.org/10.1186/s11658-026-00957-1
LA - en
ER -

CSL-JSON

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