OSCR

Hematopoietic cell kinase regulates microglial/macrophage activation to drive neuroinflammation after traumatic brain injury.

Overview

Authors: Lei Li1,2, Taoyuan Lu3, Weiwei Gao4, Fanjian Li5, Xin Guo2, Siyu Guan2, Dilmurat Gheyret2, Jinchao Wang2, Tuo Li4, Yiyao Cao2, Chuan Huang2, Rongcai Jiang3, Shu Zhang2, Dianwei Liu1, Jianning Zhang2, Xin Xu1,3
ORCID iDs: Taoyuan Lu, Xin Xu
  1. Xuanwu Hospital Jinan Branch, 5106 Jingshi Road, Jinan, Shandong 250100 China
  2. Department of Neurosurgery and Department of Physical Medicine and Rehabilitation, Tianjin Neurological Institute, Tianjin Medical University General Hospital,154 Anshan Road, Tianjin, 300052 China
  3. Department of Neurosurgery, Xuanwu Hospital, Capital Medical University,45 Changchun Street, Beijing, China
  4. Department of Neurology and Department of Neurosurgery, Tianjin Huanhu Hospital,6 Jizhao Road, Tianjin, China
  5. Department of Neurosurgery, The First Affiliated Hospital of Nanchang Medical College, Nanchang, China
Institutions: Tianjin Medical University General Hospital (China); Capital Medical University (China); Tianjin Huanhu Hospital (China); Nanchang Medical College (China); Shandong First Medical University (China)
Journal: Cell communication and signaling : CCS, volume 24, issue 1, article 319
Dates: received 9 August 2025; accepted 30 March 2026; published online 9 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12964-026-02871-7 · PMID 41952146 · PMCID PMC13217801 · OpenAlex W7151989522
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), human (organism), mouse (organism), traumatic brain injury (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Preprocessing, Connectivity, Spectral & time-frequency
Keywords: Traumatic brain injury, Neuroinflammation, Microglia/macrophage, NLRP3 inflammasome, Extracellular vesicles, Hematopoietic cell kinase
MeSH: Brain Injuries, Traumatic*, Macrophage Activation*, Macrophages*, Microglia*, Neuroinflammatory Diseases*, Proto-Oncogene Proteins c-hck*, Animals, Humans, Male, Mice, Mice, Inbred C57BL (* major topic)
Topic: Neuroinflammation and Neurodegeneration Mechanisms (Neurology, Neuroscience), according to OpenAlex
Funding: Young Scholar Project of the First Affiliated Hospital of Nanchang University (YFYPY202431); Scientific Research Program of Tianjin Education Commissiom (2024KJ248); National Natural Science Foundation of China (National Science Foundation of China) (81930031, 82471331); Taishan Scholar Project of Shandong Province (tsqn202408398); Beijing Natural Science Foundation (L2510116); Xuanwu Hospital Talent Convergence Program (HZ2025PYYX002)
Citations: not cited yet (Europe PMC); 64 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Tracing map

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Data

Data links

Data availability statement

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  • it says that the data are available on request

Read it in the paper: doi.org/10.1186/s12964-026-02871-7.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 29 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 16 authors, 6 keywords, 11 MeSH terms, 6 funders, 64 references.

Cite

This paper

Li, L., Lu, T., Gao, W., Li, F., Guo, X., Guan, S., Gheyret, D., Wang, J., Li, T., Cao, Y., Huang, C., Jiang, R., Zhang, S., Liu, D., Zhang, J., & Xu, X. (2026). Hematopoietic cell kinase regulates microglial/macrophage activation to drive neuroinflammation after traumatic brain injury. Cell communication and signaling : CCS, 24(1), 319. https://doi.org/10.1186/s12964-026-02871-7

BibTeX

@article{li2026hematopoietic,
author = {Li, Lei and Lu, Taoyuan and Gao, Weiwei and Li, Fanjian and Guo, Xin and Guan, Siyu and Gheyret, Dilmurat and Wang, Jinchao and Li, Tuo and Cao, Yiyao and Huang, Chuan and Jiang, Rongcai and Zhang, Shu and Liu, Dianwei and Zhang, Jianning and Xu, Xin},
title = {{Hematopoietic cell kinase regulates microglial/macrophage activation to drive neuroinflammation after traumatic brain injury}},
journal = {Cell communication and signaling : CCS},
year = {2026},
month = apr,
volume = {24},
number = {1},
pages = {319},
publisher = {BMC},
issn = {1478-811X},
doi = {10.1186/s12964-026-02871-7},
url = {https://doi.org/10.1186/s12964-026-02871-7},
pmid = {41952146},
pmcid = {PMC13217801}
}

RIS

TY - JOUR
AU - Li, Lei
AU - Lu, Taoyuan
AU - Gao, Weiwei
AU - Li, Fanjian
AU - Guo, Xin
AU - Guan, Siyu
AU - Gheyret, Dilmurat
AU - Wang, Jinchao
AU - Li, Tuo
AU - Cao, Yiyao
AU - Huang, Chuan
AU - Jiang, Rongcai
AU - Zhang, Shu
AU - Liu, Dianwei
AU - Zhang, Jianning
AU - Xu, Xin
TI - Hematopoietic cell kinase regulates microglial/macrophage activation to drive neuroinflammation after traumatic brain injury
T2 - Cell communication and signaling : CCS
J2 - Cell Commun Signal
PY - 2026
DA - 2026/04/09
VL - 24
IS - 1
SP - 319
SN - 1478-811X
PB - BMC
DO - 10.1186/s12964-026-02871-7
UR - https://doi.org/10.1186/s12964-026-02871-7
LA - en
ER -

CSL-JSON

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