Extracellular Vesicle and Plasma miRNAs as Candidate Biomarkers of Traumatic Brain Injury in the Context of Polytrauma.
Overview
- Department of Trauma Surgery and Orthopedics, University Hospital of Goethe University Frankfurt, 60323 Frankfurt am Main, Germany
- Department of Trauma and Reconstructive Surgery, University Hospital RWTH Aachen, 52074 Aachen, Germany
- Institute of Clinical and Experimental Trauma-Immunology, University Hospital of Ulm, 89081 Ulm, Germany
Abstract
Severe traumatic brain injury (TBI) is a leading cause of mortality and long-term disability in polytrauma (PT) patients, and its clinical outcome remains difficult to predict due to clinical heterogeneity and secondary injury mechanisms. Current diagnostic and prognostic approaches based on clinical assessment and imaging are limited, particularly in PT where neurological evaluation is often impaired. This study aimed to compare plasma- and extracellular vesicle (EV)-associated microRNA (miRNA) signatures in patients with severe TBI and healthy controls to identify their potential as minimally invasive biomarkers and to improve understanding of molecular responses. For profiling circulating miRNAs, blood samples were collected at ≤3 h and at 48 h after admission. In the screening phase, plasma samples of n = 15 patients with severe isolated TBI (Abbreviated Injury Scale [AIS]Head ≥ 4, all other AIS ≤ 1) and n = 15 age- and sex-matched healthy controls were pooled (n = 5/
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- geo:GSE325396, at NCBI GEO; found in “Data Availability Statement”
Data Availability Statement
The data discussed in this publication have been deposited in NCBI’s Gene Expression Omnibus [56] and are accessible through GEO Series accession number GSE325396 (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 5 keywords, 12 MeSH terms, 1 funder, 55 references.
Cite
This paper
Schindler, C. R., Henrich, D., Krämer, L., Schaible, I., Hörauf, J.-A., Ritter, A., Störmann, P., Groven, R. V. M., Huber-Lang, M., Marzi, I., & Leppik, L. (2026). Extracellular Vesicle and Plasma miRNAs as Candidate Biomarkers of Traumatic Brain Injury in the Context of Polytrauma. International journal of molecular sciences, 27(10), 4248. https://
BibTeX
@article{schindler2026ex
author = {Schindler, Cora Rebecca and Henrich, Dirk and Krämer, Lena and Schaible, Inna and Hörauf, Jason-Alexander and Ritter, Aileen and Störmann, Philipp and Groven, Rald Victor Maria and Huber-Lang, Markus and Marzi, Ingo and Leppik, Liudmila},
title = {{Extracellular Vesicle and Plasma miRNAs as Candidate Biomarkers of Traumatic Brain Injury in the Context of Polytrauma}},
journal = {International journal of molecular sciences},
year = {2026},
month = may,
volume = {27},
number = {10},
pages = {4248},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
issn = {1422-0067},
doi = {10.3390/
url = {https://
pmid = {42196237},
pmcid = {PMC13206937}
}
RIS
TY - JOUR
AU - Schindler, Cora Rebecca
AU - Henrich, Dirk
AU - Krämer, Lena
AU - Schaible, Inna
AU - Hörauf, Jason-Alexander
AU - Ritter, Aileen
AU - Störmann, Philipp
AU - Groven, Rald Victor Maria
AU - Huber-Lang, Markus
AU - Marzi, Ingo
AU - Leppik, Liudmila
TI - Extracellular Vesicle and Plasma miRNAs as Candidate Biomarkers of Traumatic Brain Injury in the Context of Polytrauma
T2 - International journal of molecular sciences
J2 - Int J Mol Sci
PY - 2026
DA - 2026/
VL - 27
IS - 10
SP - 4248
SN - 1422-0067
PB - Multidisciplinary Digital Publishing Institute (MDPI)
DO - 10.3390/
UR - https://
LA - en
ER -
CSL-JSON
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