OSCR

Comprehensive multiomics analyses identify guanylate cyclase activator 1A as a photoreceptor-specific target in a murine model of oxygen-induced retinopathy.

Overview

Authors: Qianhui Yang1, Jindan Wang1, Tongrui Wu2, Siyi Liu1, Yumin Zhang1, Xinglong Wang1, Weiran Zhang1, Hua Rong1, Mengyu Wu3, Yating Zhao3, Yunshan Cao3, Min Zhang4, Hui Shen5, Yan Zhang1
ORCID iDs: Hui Shen, Yan Zhang
  1. Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, 300384 China
  2. Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600 China
  3. Heart, Lung and Vessels Center, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, 610072 China
  4. Clinical Research Center, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, 610072 China
  5. Laboratory of Neurobiology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, 300070 China
Institutions: Tianjin Medical University Eye Hospital (China); Tianjin Medical University (China); Shanghai Jiao Tong University (China); University of Electronic Science and Technology of China (China); Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (China)
Journal: Journal of translational medicine, volume 24, issue 1, article 782
Dates: received 23 October 2025; accepted 23 April 2026; published online 29 April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12967-026-08207-w · PMID 42057040 · PMCID PMC13277265 · OpenAlex W7158548337
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), other (modality), histology / microscopy (modality), intracellular / patch clamp (modality), mouse (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Connectivity
Keywords: Phototransduction, Electrophysiological dysfunction, Guca1a gene, Guanylate cyclase activator 1A, Oxygen-induced retinopathy, retinopathy of prematurity
MeSH: Guanylate Cyclase-Activating Proteins*, Oxygen*, Photoreceptor Cells, Vertebrate*, Retinopathy of Prematurity*, Animals, Cyclic GMP, Disease Models, Animal, Electroretinography, Mice, Mice, Inbred C57BL, Retina (* major topic)
Topic: Retinopathy of Prematurity Studies (Radiology, Nuclear Medicine and Imaging, Medicine), according to OpenAlex
Funding: Tianjin High-level Talent Selection and Training Project in the Health Industry (TJSJMYXYC-D2-042); Natural Science Foundation of Tianjin Municipality (25JCZDJC00090); Open Project of Tianjin Key Laboratory of Retinal Functions and Diseases (2019tjswmq002); the Tianjin Medical University Eye Hospital High-level Innovative Talent Program (YDYYRCXM-E2023-06); Tianjin Medical University Eye Hospital High-level Innovative Talent Program (YDYYRCXM-B2023-01), and the Tianjin Key Medical Discipline Construction Project (YDYYRCXM-B2023-01)
Citations: cited by 1 paper (Europe PMC); 52 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none, so it has no map.

Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1186/s12967-026-08207-w.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 14 authors, 6 keywords, 11 MeSH terms, 5 funders, 52 references.

Cite

This paper

Yang, Q., Wang, J., Wu, T., Liu, S., Zhang, Y., Wang, X., Zhang, W., Rong, H., Wu, M., Zhao, Y., Cao, Y., Zhang, M., Shen, H., & Zhang, Y. (2026). Comprehensive multiomics analyses identify guanylate cyclase activator 1A as a photoreceptor-specific target in a murine model of oxygen-induced retinopathy. Journal of translational medicine, 24(1), 782. https://doi.org/10.1186/s12967-026-08207-w

BibTeX

@article{yang2026comprehensive,
author = {Yang, Qianhui and Wang, Jindan and Wu, Tongrui and Liu, Siyi and Zhang, Yumin and Wang, Xinglong and Zhang, Weiran and Rong, Hua and Wu, Mengyu and Zhao, Yating and Cao, Yunshan and Zhang, Min and Shen, Hui and Zhang, Yan},
title = {{Comprehensive multiomics analyses identify guanylate cyclase activator 1A as a photoreceptor-specific target in a murine model of oxygen-induced retinopathy}},
journal = {Journal of translational medicine},
year = {2026},
month = apr,
volume = {24},
number = {1},
pages = {782},
publisher = {BMC},
issn = {1479-5876},
doi = {10.1186/s12967-026-08207-w},
url = {https://doi.org/10.1186/s12967-026-08207-w},
pmid = {42057040},
pmcid = {PMC13277265}
}

RIS

TY - JOUR
AU - Yang, Qianhui
AU - Wang, Jindan
AU - Wu, Tongrui
AU - Liu, Siyi
AU - Zhang, Yumin
AU - Wang, Xinglong
AU - Zhang, Weiran
AU - Rong, Hua
AU - Wu, Mengyu
AU - Zhao, Yating
AU - Cao, Yunshan
AU - Zhang, Min
AU - Shen, Hui
AU - Zhang, Yan
TI - Comprehensive multiomics analyses identify guanylate cyclase activator 1A as a photoreceptor-specific target in a murine model of oxygen-induced retinopathy
T2 - Journal of translational medicine
J2 - J Transl Med
PY - 2026
DA - 2026/04/29
VL - 24
IS - 1
SP - 782
SN - 1479-5876
PB - BMC
DO - 10.1186/s12967-026-08207-w
UR - https://doi.org/10.1186/s12967-026-08207-w
LA - en
ER -

CSL-JSON

{
"id": "10.1186/s12967-026-08207-w",
"type": "article-journal",
"title": "Comprehensive multiomics analyses identify guanylate cyclase activator 1A as a photoreceptor-specific target in a murine model of oxygen-induced retinopathy",
"container-title": "Journal of translational medicine",
"author": [
{
"family": "Yang",
"given": "Qianhui"
},
{
"family": "Wang",
"given": "Jindan"
},
{
"family": "Wu",
"given": "Tongrui"
},
{
"family": "Liu",
"given": "Siyi"
},
{
"family": "Zhang",
"given": "Yumin"
},
{
"family": "Wang",
"given": "Xinglong"
},
{
"family": "Zhang",
"given": "Weiran"
},
{
"family": "Rong",
"given": "Hua"
},
{
"family": "Wu",
"given": "Mengyu"
},
{
"family": "Zhao",
"given": "Yating"
},
{
"family": "Cao",
"given": "Yunshan"
},
{
"family": "Zhang",
"given": "Min"
},
{
"family": "Shen",
"given": "Hui"
},
{
"family": "Zhang",
"given": "Yan"
}
],
"container-title-short": "J Transl Med",
"volume": "24",
"issue": "1",
"page": "782",
"DOI": "10.1186/s12967-026-08207-w",
"PMID": "42057040",
"PMCID": "PMC13277265",
"ISSN": "1479-5876",
"publisher": "BMC",
"URL": "https://doi.org/10.1186/s12967-026-08207-w",
"language": "en",
"issued": {
"date-parts": [
[
2026,
4,
29
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1038/s41598-026-49034-9
Multimodal preclinical study of long-term effects of prenatal ultrasound on the mouse central nervous system.
Journal: Scientific reports
In common: other, genetics / omics, mouse, 1 reference
[2] doi:10.1038/s41467-026-76831-7
Structural origins of species-specific differences in TRPV2 activation.
Journal: Nature communications
In common: intracellular / patch clamp, histology / microscopy, mouse, 1 other category
[3] doi:10.3390/ijms27114833
Alterations in the Components of the GABA-Glutamate System During ZIKV Infection: A Neuroscience Approach.
Journal: International journal of molecular sciences
In common: other condition, mouse, cellular / molecular, 1 reference
[4] doi:10.1093/neuonc/noag059
Combined patch-clamp electrophysiology and single-cell genomic analysis reveal spiking tumor cells at the neocortical glioblastoma interface in humans.
Journal: Neuro-oncology
In common: intracellular / patch clamp, genetics / omics, other condition, 1 other category
[5] doi:10.1371/journal.ppat.1014314
Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs.
Journal: PLoS pathogens
In common: histology / microscopy, genetics / omics, other condition, 2 other categories
[6] doi:10.1016/j.xcrm.2026.102845
Ketogenic diet as a metabolic vehicle enhancing the therapeutic efficacy of mebendazole and devimistat in juvenile syngeneic high-grade glioma.
Journal: Cell reports. Medicine
In common: other condition, mouse, 1 reference
[7] doi:10.1038/s41467-026-77508-x
Structures of the volume-regulated anion channel LRRC8A/D in activating and inhibiting conditions.
Journal: Nature communications
In common: intracellular / patch clamp, histology / microscopy, cellular / molecular
[8] doi:10.14814/phy2.71059
Impact of aging on neck vasculature and brain biochemistry in female mice.
Journal: Physiological reports
In common: histology / microscopy, other, genetics / omics, 1 other category
[9] doi:10.1016/j.isci.2026.117088 [code]
Spatial biases in visual feature representation of mouse dorsal lateral geniculate nucleus boutons.
Journal: iScience
In common: mouse, 1 reference
[10] doi:10.1167/iovs.67.8.9 [code]
Müller Glia-Exclusive CLRN1 Expression Drives Non-Cell-Autonomous Photoreceptor Degeneration in Usher Syndrome Type 3A.
Journal: Investigative ophthalmology & visual science
In common: histology / microscopy, other, genetics / omics, 1 other category

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.