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FAM135B suppresses glioblastoma angiogenesis via stabilizing the IKK complex and inactivating the NF-κB/IL-6 signaling pathway.

Overview

Authors: Chuangyuan Wang1, Fabing Zhang1, Liwei Hao2, Yujie Zhang3,4, Chenya Feng5, Nuozhou Weng6, Peiqian Hu7, Wanmei Lin4, Taoliang Chen1, Tianwei Wang1, Yinian Zhang1, Yiquan Ke1,8, Liang Zhao3,4, Zetao Chen1
ORCID iDs: Yiquan Ke, Zetao Chen
  1. Neurosurgery Center, Department of Neuro-oncological Surgery, The National Key Clinical Specialty, Engineering Research Center of Diagnostic and Therapeutic Technology and Devices for Cerebrovascular Diseases, Ministry of Education, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, Zhujiang Hospital Institute for Brain Science and Intelligence, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282 China
  2. Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province China
  3. Department of Pathology, Shunde Hospital, Southern Medical University, (The First People’s Hospital of Shunde), Foshan, China
  4. Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
  5. Department of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, China
  6. Department of General Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, China
  7. Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, China
  8. Department of Neurosurgery, School of Medicine, The Sixth Affiliated Hospital of South China University of Technology (Nanhai District People’s Hospital of Foshan), Foshan, 528200 China
Journal: Journal of translational medicine, volume 24, issue 1, article 1046
Dates: received 19 October 2025; accepted 29 May 2026; published online 8 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s12967-026-08397-3 · PMID 42260484 · PMCID PMC13471341 · OpenAlex W7163937198
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Connectivity
Keywords: Angiogenesis, FAM135B, NFκB, IL-6, Glioblastoma
MeSH: Brain Neoplasms*, Glioblastoma*, I-kappa B Kinase*, Interleukin-6*, Neovascularization, Pathologic*, NF-kappa B*, Signal Transduction*, Animals, Cell Line, Tumor, Cell Movement, Gene Expression Regulation, Neoplastic, Human Umbilical Vein Endothelial Cells, Humans, Mice, Mice, Nude, Prognosis (* major topic)
Topic: Glioma Diagnosis and Treatment (Genetics, Medicine), according to OpenAlex
Funding: National Natural Science Foundation of China (82203605, 82072762); China Postdoctoral Science Foundation (2021M701610)
Citations: not cited yet (Europe PMC); 27 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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  • no repository, dataset or request procedure was recognized in it

Read it in the paper: doi.org/10.1186/s12967-026-08397-3.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 14 authors, 5 keywords, 16 MeSH terms, 2 funders, 26 references.

Cite

This paper

Wang, C., Zhang, F., Hao, L., Zhang, Y., Feng, C., Weng, N., Hu, P., Lin, W., Chen, T., Wang, T., Zhang, Y., Ke, Y., Zhao, L., & Chen, Z. (2026). FAM135B suppresses glioblastoma angiogenesis via stabilizing the IKK complex and inactivating the NF-κB/IL-6 signaling pathway. Journal of translational medicine, 24(1), 1046. https://doi.org/10.1186/s12967-026-08397-3

BibTeX

@article{wang2026fam135b,
author = {Wang, Chuangyuan and Zhang, Fabing and Hao, Liwei and Zhang, Yujie and Feng, Chenya and Weng, Nuozhou and Hu, Peiqian and Lin, Wanmei and Chen, Taoliang and Wang, Tianwei and Zhang, Yinian and Ke, Yiquan and Zhao, Liang and Chen, Zetao},
title = {{FAM135B suppresses glioblastoma angiogenesis via stabilizing the IKK complex and inactivating the NF-κB/IL-6 signaling pathway}},
journal = {Journal of translational medicine},
year = {2026},
month = jun,
volume = {24},
number = {1},
pages = {1046},
publisher = {BMC},
issn = {1479-5876},
doi = {10.1186/s12967-026-08397-3},
url = {https://doi.org/10.1186/s12967-026-08397-3},
pmid = {42260484},
pmcid = {PMC13471341}
}

RIS

TY - JOUR
AU - Wang, Chuangyuan
AU - Zhang, Fabing
AU - Hao, Liwei
AU - Zhang, Yujie
AU - Feng, Chenya
AU - Weng, Nuozhou
AU - Hu, Peiqian
AU - Lin, Wanmei
AU - Chen, Taoliang
AU - Wang, Tianwei
AU - Zhang, Yinian
AU - Ke, Yiquan
AU - Zhao, Liang
AU - Chen, Zetao
TI - FAM135B suppresses glioblastoma angiogenesis via stabilizing the IKK complex and inactivating the NF-κB/IL-6 signaling pathway
T2 - Journal of translational medicine
J2 - J Transl Med
PY - 2026
DA - 2026/06/08
VL - 24
IS - 1
SP - 1046
SN - 1479-5876
PB - BMC
DO - 10.1186/s12967-026-08397-3
UR - https://doi.org/10.1186/s12967-026-08397-3
LA - en
ER -

CSL-JSON

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